INT152030

Context Info Confidence 0.55 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 10 Total Number 13 Disease Relevance 8.09 Pain Relevance 7.08

extracellular region (Postn) cell adhesion (Postn) proteinaceous extracellular matrix (Postn) extracellular matrix organization (Postn)

Anatomy Link Frequency dorsal 1 periosteum 1 stromal cells 1 periodontal ligament 1 Keratinocytes 1 Postn (Mus musculus)

Pain Link Frequency Relevance Heat headache 30 100.00 cytokine 283 99.96 Raphe 35 98.88 Analgesic 17 98.68 Mcgill questionnaire 4 97.92 Morphine 211 97.72 Chronic pancreatitis 2 96.76 peripheral neuropathy 6 96.24 Spinal cord 6 92.52 Opioid 123 91.92

Disease Link Frequency Relevance Heat Headache 26 100.00 Migraine Disorders 6 99.20 Pain 115 97.36 Pancreatitis 2 96.76 Peripheral Neuropathy 12 96.24 Injury 76 96.00 Convulsion 15 95.12 Cancer 20 93.16 Nociception 90 91.96 INFLAMMATION 24 90.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

S1), suggesting that periostin might regulate Notch1 expression in various tissues that express periostin.

Gene_expression (express) of periostin

1) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 0 Pain Relevance 0

Periostin gene expression was detected solely in the stromal cells on in situ hybridization.

Gene_expression (expression) of Periostin in stromal cells

2) Confidence 0.52 Published 2008 Journal Mod. Pathol. Section Abstract Doc Link 18487994 Disease Relevance 1.58 Pain Relevance 0.18

We immunoprecipitated periostin using an anti-Myc antibody from the another whole-cell lysates of HEK293T transfectants that co-expressed Notch1-FLAG and periostin-Myc constructs and then performed Western blot analysis using an antibody raised against the extracellular region of rodent Notch1.

Gene_expression (expressed) of periostin-Myc

3) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 0 Pain Relevance 0

However, neither interictal migraines nor a positive family history of migraines was significantly predictive of either peri-ictal headaches or migrainous peri-ictal headaches.

Gene_expression (headaches) of peri-ictal associated with migraine disorders and headache

4) Confidence 0.48 Published 2008 Journal Pediatr. Neurol. Section Abstract Doc Link 18639751 Disease Relevance 1.80 Pain Relevance 1.25

However, neither interictal migraines nor a positive family history of migraines was significantly predictive of either peri-ictal headaches or migrainous peri-ictal headaches.

Gene_expression (headaches) of peri-ictal associated with migraine disorders and headache

5) Confidence 0.48 Published 2008 Journal Pediatr. Neurol. Section Abstract Doc Link 18639751 Disease Relevance 1.79 Pain Relevance 1.24

Expression of periostin is principally observed in mesenchymal tissues during embryogenesis, and, in the adult, it is restricted to certain tissues such as periodontal ligament, periosteum [2], and cardiac valves [5], which are mechanically stressed tissues, and healing tissues [6], [7], [8], [9].

Gene_expression (Expression) of periostin in periodontal ligament

6) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 0.29 Pain Relevance 0.08

Expression of periostin is principally observed in mesenchymal tissues during embryogenesis, and, in the adult, it is restricted to certain tissues such as periodontal ligament, periosteum [2], and cardiac valves [5], which are mechanically stressed tissues, and healing tissues [6], [7], [8], [9].

Gene_expression (Expression) of periostin in periosteum

7) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 0.29 Pain Relevance 0.08

Effects of Neuragen PN®

Gene_expression (Effects) of Neuragen PN

8) Confidence 0.13 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2883533 Disease Relevance 0.44 Pain Relevance 0.45

More importantly, we went on in the present studies to show that the peri-incisional expression of cytokines previously demonstrated to be inhibited by morphine given acutely before incision [31] were moderately to strongly enhanced in the tissues of mice chronically pretreated with morphine.

Gene_expression (expression) of peri-incisional associated with morphine and cytokine

9) Confidence 0.04 Published 2008 Journal Mol Pain Section Body Doc Link PMC2279109 Disease Relevance 0.44 Pain Relevance 1.30

OXA-ir fibres and terminals were found in many brain areas including the PeriSCN region and within the IGL, MRN, and dorsal raphe (DRN) (Additional file 1).

Gene_expression (found) of PeriSCN in dorsal associated with raphe

10) Confidence 0.03 Published 2008 Journal Mol Brain Section Body Doc Link PMC2632999 Disease Relevance 0 Pain Relevance 0.15

Our previous studies used immunohistochemical techniques to demonstrate that both infiltrating neutrophils and peri-incisional keratinocytes produce the cytokines we measured as elevated after incision [31].

Gene_expression (keratinocytes) of peri-incisional in neutrophils associated with cytokine

11) Confidence 0.03 Published 2008 Journal Mol Pain Section Body Doc Link PMC2279109 Disease Relevance 0.58 Pain Relevance 1.15

Keratinocytes were identified as an alternative source of peri-incisional cytokines.

Gene_expression (source) of peri-incisional in Keratinocytes associated with cytokine

12) Confidence 0.03 Published 2007 Journal Mol Pain Section Body Doc Link PMC2096620 Disease Relevance 0.86 Pain Relevance 1.20

At PN14, SNAP-25b levels were five times higher than SNAP-25a in WT mice, heterozygous neo-containing mutants had equal amounts of both SNAP-25 mRNA isoforms, while homozygous neo-containing SNAP-25b deficient mutants only expressed SNAP-25a (Figure 1C).

Gene_expression (levels) of PN14

13) Confidence 0.01 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0 Pain Relevance 0

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