INT152035

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Context Info
Confidence 0.31
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 6.95
Pain Relevance 3.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HLA-A, MRAP) endoplasmic reticulum (MRAP) cytoplasm (MRAP)
Anatomy Link Frequency
joint 2
leukocyte 1
HLA-A (Homo sapiens)
MRAP (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 356 100.00 Very High Very High Very High
spinal inflammation 9 99.84 Very High Very High Very High
psoriasis 204 99.32 Very High Very High Very High
rheumatoid arthritis 44 85.36 High High
Inflammation 48 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Crohn's disease 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Seronegative Spondarthritis 292 100.00 Very High Very High Very High
Low Back Pain 1 99.84 Very High Very High Very High
Psoriasis 204 99.32 Very High Very High Very High
Sacroiliitis 4 97.78 Very High Very High Very High
Disease 51 95.64 Very High Very High Very High
Rheumatoid Arthritis 44 85.36 High High
Recurrence 8 27.84 Quite Low
Genetic Predisposition To Disease 20 15.60 Low Low
Arthritis 80 11.88 Low Low
INFLAMMATION 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, there have been reports of association with PsA to the HLA B locus, particularly with B7 and B27, independent of psoriasis [22,31,34].
HLA Binding (association) of B27 associated with psoriasis and arthritis
1) Confidence 0.31 Published 2002 Journal Arthritis Res Section Body Doc Link PMC128931 Disease Relevance 1.67 Pain Relevance 0.82
The association with B27 is particularly strong in PsA patients with sacroiliitis, but it has also been detected in patients with distal interphalangeal joint involvement, suggesting that the HLA-B27 association may not simply reflect the co-incidence of ankylosing spondylitis with psoriasis [31].
HLA Binding (association) of B27 in joint associated with psoriasis, spinal inflammation, sacroiliitis and arthritis
2) Confidence 0.26 Published 2002 Journal Arthritis Res Section Body Doc Link PMC128931 Disease Relevance 1.65 Pain Relevance 0.82
The association with B27 is particularly strong in PsA patients with sacroiliitis, but it has also been detected in patients with distal interphalangeal joint involvement, suggesting that the HLA-B27 association may not simply reflect the co-incidence of ankylosing spondylitis with psoriasis [31].
HLA Binding (association) of B27 in joint associated with psoriasis, spinal inflammation, sacroiliitis and arthritis
3) Confidence 0.26 Published 2002 Journal Arthritis Res Section Body Doc Link PMC128931 Disease Relevance 1.65 Pain Relevance 0.82
Conversely, there have been reports of association with PsA to the HLA B locus, particularly with B7 and B27, independent of psoriasis [22,31,34].
HLA Binding (association) of B27 associated with psoriasis and arthritis
4) Confidence 0.23 Published 2002 Journal Arthritis Res Section Body Doc Link PMC128931 Disease Relevance 1.67 Pain Relevance 0.82
The association of human leukocyte antigen (HLA)-B27 to ankylosing spondylitis is one of the strongest between a major histocompatibility complex molecule and a disease.
HLA Binding (association) of B27 in leukocyte associated with spinal inflammation and disease
5) Confidence 0.16 Published 2008 Journal Tissue Antigens Section Abstract Doc Link 18489433 Disease Relevance 0.32 Pain Relevance 0.10

General Comments

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