INT152045

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Context Info
Confidence 0.57
First Reported 2003
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 6.42
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 3
Trav6-3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 188 98.64 Very High Very High Very High
Inflammation 158 98.44 Very High Very High Very High
Inflammatory response 15 92.64 High High
rheumatoid arthritis 176 91.44 High High
tolerance 13 81.44 Quite High
Neuritis 1 73.84 Quite High
withdrawal 8 70.32 Quite High
Arthritis 40 50.00 Quite Low
chemokine 24 38.80 Quite Low
cINOD 6 10.32 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 170 98.44 Very High Very High Very High
Cockayne Syndrome 36 97.36 Very High Very High Very High
Hypoxia 6 96.86 Very High Very High Very High
Hematologic Neoplasms 6 94.72 High High
Death 19 94.24 High High
Disease 119 94.00 High High
Solid Tumor 6 93.56 High High
Lifespan 15 93.48 High High
Systemic Lupus Erythematosus 6 92.76 High High
Osteoporosis 1 92.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results point out that the combination of reduced TCR and peptide challenge leads to a phenotypic change resulting in T cell anergy.
Negative_regulation (reduced) of TCR in T cell
1) Confidence 0.57 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18490725 Disease Relevance 0.53 Pain Relevance 0.07
may serve to attenuate T-cell activation at sites of tissue damage, thereby limiting the effects of unbridled T-cell reactivity and pathologic effector responses.14,15 Whilst this model is entirely consistent with a central role for antigen in driving autoimmune inflammatory activity, it implies that chronically activated T cells rendered hyporesponsive to TCR engagement through loss of TCR?
Negative_regulation (loss) of TCR in T cells associated with inflammation
2) Confidence 0.15 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0.83 Pain Relevance 0.11
This subset will include populations of T cells that have very recently engaged antigen, perhaps explaining their refractoriness to TCR restimulation, but also T cells in which loss of TCR?
Negative_regulation (loss) of TCR in T cells
3) Confidence 0.15 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0.21 Pain Relevance 0.15
In spite of its structural diversity, however, the repertoire of functional TCR is still greatly outnumbered by potential antigenic peptides, particularly in small mammals such as the mouse.
Negative_regulation (outnumbered) of TCR
4) Confidence 0.13 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193735 Disease Relevance 0.08 Pain Relevance 0.04
TTD patients are partially defective in TCR as well as in the GG-NER, and share the symptoms associated with CS.
Spec (partially) Negative_regulation (defective) of TCR associated with cockayne syndrome
5) Confidence 0.13 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1698505 Disease Relevance 1.95 Pain Relevance 0
Furthermore, disruption of the interaction between SLP-76 and Gads has been shown to impair TCR signaling in Jurkat cells by approximately 50% [10,11].
Negative_regulation (impair) of TCR
6) Confidence 0.11 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0 Pain Relevance 0
We suggest that on migration to tissues in vivo this subset would be exposed to an inflammatory milieu where hypoxia, reactive oxygen intermediates, depletion of essential nutrients, inflammatory cytokines, and activated cells of myeloid lineage each contribute to chronic down-regulation of TCR?
Negative_regulation (down-regulation) of TCR associated with inflammation, hypoxia and cytokine
7) Confidence 0.11 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0.49 Pain Relevance 0.26
That this phenomenon is associated with so many diverse pathologies has raised the possibility that down-regulation of TCR?
Negative_regulation (regulation) of TCR
8) Confidence 0.11 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0.78 Pain Relevance 0.09
bright counterparts, implying that migration is associated with, and perhaps even facilitated by, loss of TCR?
Negative_regulation (loss) of TCR
9) Confidence 0.11 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0.34 Pain Relevance 0.23
dim), we explored the relationship between loss of TCR?
Negative_regulation (loss) of TCR
10) Confidence 0.11 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0.84 Pain Relevance 0.11
TCR is limited, suggesting that the ligands for the ??
Negative_regulation (limited) of TCR
11) Confidence 0.09 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.37 Pain Relevance 0.10

General Comments

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