INT152046

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.47
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 6
macrophage 2
effector T lymphocytes 2
Trav6-3 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 10 99.84 Very High Very High Very High
cytokine 119 98.70 Very High Very High Very High
Inflammatory response 5 92.76 High High
rheumatoid arthritis 41 91.92 High High
Inflammation 69 77.04 Quite High
tolerance 6 69.04 Quite High
withdrawal 5 58.12 Quite High
Arthritis 10 41.84 Quite Low
chemokine 13 26.60 Quite Low
Neuritis 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Cancer 192 98.76 Very High Very High Very High
Necrosis 5 98.52 Very High Very High Very High
Cold Sores 20 96.52 Very High Very High Very High
Death 57 96.36 Very High Very High Very High
Infection 74 96.16 Very High Very High Very High
Glioma 9 95.64 Very High Very High Very High
Alagille Syndrome 1 92.60 High High
INFLAMMATION 79 92.40 High High
Rheumatoid Arthritis 42 91.92 High High
Targeted Disruption 7 90.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because self-reactive T cells may have low affinity for peptide:MHC, we investigated whether myelin-reactive T cells require these excess TCR for optimal response.
Positive_regulation (require) of Positive_regulation (excess) of TCR in T cells
1) Confidence 0.45 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18490725 Disease Relevance 0.18 Pain Relevance 0
These results demonstrate that Fas activation, which requires repeated TCR stimulation to upregulate FasL in T cells, is not involved in the shutdown of acute immune responses; instead, this death is mediated predominantly by Bim.


Positive_regulation (upregulate) of Positive_regulation (stimulation) of TCR in T cells associated with death
2) Confidence 0.14 Published 2008 Journal Immunity Section Body Doc Link PMC2270348 Disease Relevance 1.38 Pain Relevance 0
Furthermore, transendothelial migration experiments demonstrated an enhanced propensity for circulating TCR?
Positive_regulation (enhanced) of Positive_regulation (circulating) of TCR
3) Confidence 0.13 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0.37 Pain Relevance 0.22
AKT activation cooperates with the TCR-induced activation of protein kinase C (PKC)?
Positive_regulation (activation) of Positive_regulation (activation) of TCR-induced associated with kinase c
4) Confidence 0.11 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582810 Disease Relevance 0 Pain Relevance 0.14
However, when data were stratified according to validated EULAR clinical response criteria we found that at 30 weeks the best clinical outcomes were associated with an accumulation in the percent CD3+TCR?
Positive_regulation (according) of Positive_regulation (accumulation) of TCR
5) Confidence 0.11 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0.35 Pain Relevance 0.11
CTLA4 is also expressed in the ER of helper and effector T lymphocytes and cell surface expression is upregulated 24 to 48 h after activation of TCR [48].
Positive_regulation (upregulated) of Positive_regulation (activation) of TCR in effector T lymphocytes
6) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291560 Disease Relevance 0.52 Pain Relevance 0.03
Surprisingly, when the ability of the public TCR to recognize these NP366 peptide variants was examined, only the cognate NP366/Db ligand derived from the NP of the PR8 virus was able to trigger the activation of the TCR transfectant (Fig. 5B).
Positive_regulation (trigger) of Positive_regulation (activation) of TCR
7) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2868023 Disease Relevance 0.14 Pain Relevance 0
Furthermore, CD28 co-stimulation synergizes with TCR activation and induces IL-2, IL-4, IL-5, tumor necrosis factor (TNF), and granulocyte macrophage colony-stimulating factor production via nuclear factor-kappa B (NF-?
Positive_regulation (synergizes) of Positive_regulation (activation) of TCR in macrophage associated with necrosis and cancer
8) Confidence 0.04 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684090 Disease Relevance 0.52 Pain Relevance 0
Cytokines present within the milieu in which human naïve CD4+ T cells are activated via stimulation of the TCR complex and co-stimulatory molecules dictate whether these cells commit to Th1, Th2, Th17 or regulatory (Treg) T cell phenotype [1]–[4].
Positive_regulation (activated) of Positive_regulation (stimulation) of TCR in T cell associated with cytokine
9) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0 Pain Relevance 0.05

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