INT152048

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Context Info
Confidence 0.57
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.47
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 4
Trav6-3 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuritis 3 99.28 Very High Very High Very High
COX2 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 3 99.68 Very High Very High Very High
Optic Neuritis 3 99.28 Very High Very High Very High
Autoimmune Disease 9 98.12 Very High Very High Very High
Alagille Syndrome 3 98.12 Very High Very High Very High
Disease 3 94.00 High High
Renal Cancer 8 89.92 High High
Cancer 32 89.12 High High
Targeted Disruption 4 88.60 High High
Apoptosis 3 74.16 Quite High
Genetic Translocation 2 40.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous studies have found that a 95% reduction in TCR expression does not adversely affect response to foreign Ags, indicating that T cells have an excess of TCR for Ag recognition.
Negative_regulation (reduction) of Gene_expression (expression) of TCR in T cells associated with alagille syndrome
1) Confidence 0.57 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18490725 Disease Relevance 0.17 Pain Relevance 0
Thus, reduction of TCR expression may provide a potential therapy for self-reactive T cells involved in autoimmune diseases through the induction of anergy.
Negative_regulation (reduction) of Gene_expression (expression) of TCR in T cells associated with autoimmune disease
2) Confidence 0.57 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18490725 Disease Relevance 0.64 Pain Relevance 0.10
These cells have a dramatic Ab dose-dependent reduction in proliferation, with a small reduction in TCR expression leading to a 50% reduction in proliferation in vitro.
Negative_regulation (reduction) of Gene_expression (expression) of TCR
3) Confidence 0.57 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18490725 Disease Relevance 0.27 Pain Relevance 0
We envision a model whereby one copy of TRC8 is disrupted by palindrome-mediated translocation (step 1), then, in a second step, translin, miRNA, or another yet undiscovered mechanism leads to further loss of TCR8 expression, setting the stage for deregulated proliferation.


Negative_regulation (loss) of Gene_expression (expression) of TCR8
4) Confidence 0.00 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2727492 Disease Relevance 0.40 Pain Relevance 0

General Comments

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