INT152057

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Context Info
Confidence 0.43
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.00
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2l1) intracellular (Bcl2l1) response to stress (Bcl2l1)
cytoplasm (Bcl2l1) cytosol (Bcl2l1) cell proliferation (Bcl2l1)
Anatomy Link Frequency
optic nerve 2
hippocampus 2
Bcl2l1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 3 99.68 Very High Very High Very High
Clonidine 2 99.22 Very High Very High Very High
agonist 2 83.92 Quite High
antagonist 1 81.84 Quite High
ischemia 32 68.32 Quite High
cytokine 3 64.52 Quite High
Mechanotransduction 1 63.60 Quite High
Central nervous system 2 18.44 Low Low
anesthesia 4 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 63 97.80 Very High Very High Very High
Fistula 21 96.44 Very High Very High Very High
Ganglion Cysts 3 73.12 Quite High
Glaucoma 1 69.08 Quite High
Cv General 4 Under Development 4 69.04 Quite High
Stress 19 57.04 Quite High
Retina Disease 17 50.00 Quite Low
Ocular Hypertension 8 36.28 Quite Low
Cv Unclassified Under Development 11 35.12 Quite Low
Death 8 31.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Administration of clonidine 20 min after yohimbine administration abolished its effect on Bcl-XL mRNA level in the hippocampus.
Negative_regulation (abolished) of Transcription (level) of Bcl-XL in hippocampus associated with hippocampus and clonidine
1) Confidence 0.43 Published 2008 Journal Izv. Akad. Nauk. Ser. Biol. Section Abstract Doc Link 18491567 Disease Relevance 0.07 Pain Relevance 0.45
Our results are in agreement with the moderate decrease in Bcl-xL mRNA expression in the retina observed after optic nerve crush [25].
Negative_regulation (decrease) of Transcription (expression) of Bcl-xL in optic nerve
2) Confidence 0.41 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.28 Pain Relevance 0.03
For example, the mRNA levels of Bcl-xS were initially decreased at 1 day, 3 days and 1 week followed by returning to base line level after 2 weeks.
Negative_regulation (decreased) of Transcription (levels) of Bcl-xS
3) Confidence 0.25 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC119850 Disease Relevance 0.64 Pain Relevance 0.06

General Comments

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