INT152074

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Context Info
Confidence 0.71
First Reported 2004
Last Reported 2008
Negated 2
Speculated 1
Reported most in Body
Documents 2
Total Number 43
Disease Relevance 29.66
Pain Relevance 2.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (KLK7) extracellular region (KLK7)
Anatomy Link Frequency
BxPC-3 13
cleavage 1
lung 1
KLK7 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 1 95.92 Very High Very High Very High
Chronic pancreatitis 630 95.36 Very High Very High Very High
opiate 1 85.92 High High
Nerve growth factor 1 83.72 Quite High
Spinal cord 1 79.92 Quite High
Inflammation 1 57.68 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 1 100.00 Very High Very High Very High
Pancreatic Cancer 1596 99.92 Very High Very High Very High
Cancer 840 99.60 Very High Very High Very High
Adenocarcinoma 588 99.40 Very High Very High Very High
Ovarian Cancer 42 98.24 Very High Very High Very High
Adhesions 504 97.72 Very High Very High Very High
Lung Cancer 42 97.60 Very High Very High Very High
Disease 85 96.88 Very High Very High Very High
Malignant Neoplastic Disease 252 95.96 Very High Very High Very High
Pancreatitis 714 95.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, recently we have further demonstrated that KLK7/hK7 is overexpressed in pancreatic adenocarcinomas [13].
Gene_expression (overexpressed) of hK7 associated with adenocarcinoma
1) Confidence 0.71 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 1.16 Pain Relevance 0
Studies have also shown that hK7 is overexpressed in squamous cervical cancerous cells [34], ovarian tumor cells [35,36], cervical adenocarcinomas [37], and in lung cancer [38].
Gene_expression (overexpressed) of hK7 in lung associated with adenocarcinoma, lung cancer and ovarian cancer
2) Confidence 0.71 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 1.16 Pain Relevance 0
In this manner, the effects on Dsg2 in cells with and without KLK7 expression could be compared, which could yield insights into changes in desmosomal proteins upon hK7 expression.
Gene_expression (expression) of hK7
3) Confidence 0.71 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.47 Pain Relevance 0
To provide more direct evidence for a relationship between hK7 expression and the decreased intensity of desmogleins observed by immunohistochemistry, in vitro substrate degradation assays were performed.
Gene_expression (expression) of hK7
4) Confidence 0.71 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.32 Pain Relevance 0.06
For example, the tumor section stained for Dsg2 (Figure 2C, this study), showing a loss of Dsg2 immunoreactivity, is from the same tissue used to demonstrate increased hK7 expression in pancreatic tumors (Figure 2A, ref. [13]).
Gene_expression (expression) of hK7 associated with cancer and pancreatic cancer
5) Confidence 0.71 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.87 Pain Relevance 0.23
A comparison of KLK7-transfected and vector-transfected pancreatic cancer cells reveals that hK7 expression alters cell morphology (Additional file 3), with cells expressing hK7 exhibiting a more flattened, less refractive appearance and reduced cell-cell contacts.
Gene_expression (expression) of hK7 associated with pancreatic cancer
6) Confidence 0.71 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.48 Pain Relevance 0
Thus, there appeared to be a clear inverse correlation between the expression of hK7 and the membrane intensity of desmosomal proteins in pancreatic samples from diseased and non-diseased conditions.
Gene_expression (expression) of hK7
7) Confidence 0.71 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.54 Pain Relevance 0.13
These findings suggest that decreased levels of desmosomal proteins seen in pancreatic cancer may result from the action of hK7 overexpressed in these tumors.
Gene_expression (overexpressed) of hK7 associated with cancer and pancreatic cancer
8) Confidence 0.71 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.50 Pain Relevance 0
Moreover, recently we have further demonstrated that KLK7/hK7 is overexpressed in pancreatic adenocarcinomas [13].
Gene_expression (overexpressed) of KLK7 associated with adenocarcinoma
9) Confidence 0.71 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 1.16 Pain Relevance 0
Based on the aberrant expression of hK7 in pancreatic cancer, in this study we sought to determine whether the desmogleins may be substrates of hK7 in pancreatic cancer.
Gene_expression (expression) of hK7 associated with pancreatic cancer
10) Confidence 0.71 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.94 Pain Relevance 0
Since BxPC-3 cells do not express hK7, we used these cells to mimic the aberrant expression of KLK7 observed in pancreatic tumors by expressing high levels of hK7 through stable transfection.
Neg (not) Gene_expression (express) of hK7 in BxPC-3 associated with pancreatic cancer
11) Confidence 0.71 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.33 Pain Relevance 0
In this manner, the effects on Dsg2 in cells with and without KLK7 expression could be compared, which could yield insights into changes in desmosomal proteins upon hK7 expression.
Gene_expression (expression) of KLK7
12) Confidence 0.71 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.46 Pain Relevance 0
Since BxPC-3 cells do not express hK7, we used these cells to mimic the aberrant expression of KLK7 observed in pancreatic tumors by expressing high levels of hK7 through stable transfection.
Gene_expression (expression) of KLK7 in BxPC-3 associated with pancreatic cancer
13) Confidence 0.71 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.39 Pain Relevance 0
A comparison of KLK7-transfected and vector-transfected pancreatic cancer cells reveals that hK7 expression alters cell morphology (Additional file 3), with cells expressing hK7 exhibiting a more flattened, less refractive appearance and reduced cell-cell contacts.
Gene_expression (expressing) of hK7 associated with pancreatic cancer
14) Confidence 0.71 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.47 Pain Relevance 0
In BxPC-3 cells expressing hK7, a marked increase in the shedding of an 80-kDa sDsg2 fragment was observed compared to a vector-transfected control.
Gene_expression (expressing) of hK7 in BxPC-3
15) Confidence 0.71 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.48 Pain Relevance 0
This has also been exemplified in the itchy and hyperkeratotic phenotype of the stratum corneum chymotryptic enzyme (SCCE) transgenic mouse model, which is over-expressing a serine protease.
Gene_expression (expressing) of SCCE associated with targeted disruption
16) Confidence 0.65 Published 2004 Journal Int J Cosmet Sci Section Abstract Doc Link 18494919 Disease Relevance 1.16 Pain Relevance 0.24
Effect of hK7 expression on Dsg2 in BxPC-3 pancreatic cancer cells
Gene_expression (expression) of hK7 in BxPC-3 associated with pancreatic cancer
17) Confidence 0.55 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.24 Pain Relevance 0
In a previous study, we have reported that kallikrein 7 (KLK7/hK7) is overexpressed in pancreatic adenocarcinomas and enhances pancreatic cancer cell invasion by shedding E-cadherin [13].
Gene_expression (overexpressed) of kallikrein 7 associated with adenocarcinoma and pancreatic cancer
18) Confidence 0.55 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 1.14 Pain Relevance 0
However, the effects of hK7 expression on desmosomal proteins in any type of cancer, including pancreatic cancer where overexpression of KLK7/hK7 has been clearly established, have not been studied.
Gene_expression (expression) of hK7 associated with cancer and pancreatic cancer
19) Confidence 0.55 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 1.25 Pain Relevance 0.08
Using a cell-based system, we have found that expression of hK7 results in a marked increase in the shedding of an 80-kDa soluble fragment of Dsg2 into the conditioned medium of BxPC-3 cells.
Gene_expression (expression) of hK7 in BxPC-3
20) Confidence 0.55 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.36 Pain Relevance 0.09

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