INT152082

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.28
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) transport (Trpv1) plasma membrane (Trpv1)
transmembrane transport (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
skin 2
Trpv1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 13 95.96 Very High Very High Very High
Kinase C 6 91.36 High High
Thermal hyperalgesia 9 84.64 Quite High
qutenza 77 80.88 Quite High
bradykinin 6 69.56 Quite High
withdrawal 1 50.68 Quite High
Pain 31 41.28 Quite Low
Cannabinoid 1 39.24 Quite Low
Neuropeptide 2 38.00 Quite Low
calcitonin gene related peptide 14 34.40 Quite Low
Disease Link Frequency Relevance Heat
Hyperalgesia 14 75.00 Quite High
Pain 39 41.28 Quite Low
Nociception 17 39.20 Quite Low
Inflammatory Pain 3 34.40 Quite Low
Neuropathic Pain 6 28.00 Quite Low
INFLAMMATION 21 25.72 Quite Low
Targeted Disruption 12 5.00 Very Low Very Low Very Low
Diabetes Mellitus 6 5.00 Very Low Very Low Very Low
Overactive Bladder 6 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PKC-mediated phos-phorylation of TRPV1 can reduce its activation threshold by partially activating the receptor such that lower concentrations of the agonist can fully activate the receptor [4, 138, 193].
Negative_regulation (reduce) of Phosphorylation (phos) of TRPV1 associated with agonist
1) Confidence 0.43 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0 Pain Relevance 0.16
Incubation of ET-1 and intraplantar ET-1 evoked phosphorylation of TRPV1 in HEK293 cells expressing TRPV1 and ET(A) and the skin, respectively.
Negative_regulation (evoked) of Phosphorylation (phosphorylation) of TRPV1 in skin
2) Confidence 0.41 Published 2008 Journal Neuroscience Section Abstract Doc Link 18495351 Disease Relevance 0.28 Pain Relevance 0.79

General Comments

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