INT152111

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.85
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL1B) signal transduction (IL1B) extracellular space (IL1B)
aging (IL1B) extracellular region (IL1B) cell-cell signaling (IL1B)
Anatomy Link Frequency
synapses 1
IL1B (Homo sapiens)
Ltp (Mus musculus)
Pain Link Frequency Relevance Heat
depression 2 100.00 Very High Very High Very High
withdrawal 1 99.62 Very High Very High Very High
Nerve growth factor 3 93.12 High High
Inflammation 2 91.20 High High
cytokine 3 88.76 High High
Pain 2 88.24 High High
antidepressant 1 83.20 Quite High
Multiple sclerosis 1 75.36 Quite High
gABA 1 74.36 Quite High
Glutamate 1 73.48 Quite High
Disease Link Frequency Relevance Heat
Depression 2 100.00 Very High Very High Very High
INFLAMMATION 2 91.20 High High
Pain 1 88.24 High High
Stress 1 84.56 Quite High
Cerebral Palsy 1 82.24 Quite High
Neurodegenerative Disease 1 80.96 Quite High
Motor Neuron Diseases 1 78.08 Quite High
Apoptosis 1 60.48 Quite High
Demyelinating Disease 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interleukin (IL)1beta can exacerbate the immediate effects of stressors, and enhance and prolong the overall effects, which may be protective in preventing overuse or by increasing conservation-withdrawal: in some synapses IL1beta induces long term depression (LTD) or blocks LTP.
IL1beta Negative_regulation (blocks) of LTP in synapses associated with depression and withdrawal
1) Confidence 0.03 Published 2008 Journal Novartis Found. Symp. Section Abstract Doc Link 18497106 Disease Relevance 0.85 Pain Relevance 0.66

General Comments

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