INT152113

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Context Info
Confidence 0.33
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 2.09
Pain Relevance 2.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Ngf) Golgi apparatus (NTSR1) endoplasmic reticulum (NTSR1)
signal transducer activity (NTSR1) extracellular space (Ngf) signal transduction (Ngf)
Anatomy Link Frequency
Nerve 2
NTSR1 (Homo sapiens)
Ngf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 22 100.00 Very High Very High Very High
Inflammation 16 98.84 Very High Very High Very High
Hyperalgesia 8 98.44 Very High Very High Very High
IPN 4 88.16 High High
Calcitonin gene-related peptide 2 84.92 Quite High
cytokine 6 75.00 Quite High
Glutamate 2 73.76 Quite High
gABA 2 71.60 Quite High
Inflammatory mediators 2 69.24 Quite High
antidepressant 2 54.80 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 2 99.88 Very High Very High Very High
INFLAMMATION 12 98.84 Very High Very High Very High
Hyperalgesia 8 98.44 Very High Very High Very High
Hypersensitivity 2 75.00 Quite High
Nociception 2 66.68 Quite High
Inflammatory Pain 4 64.76 Quite High
Stress 2 51.36 Quite High
Depression 4 38.80 Quite Low
Pain 2 25.00 Low Low
Cerebral Palsy 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nerve growth factor (NGF) binds to TrkA receptors (neurotrophic) and P75(NTR) (apoptosis or other pathways depending on the coupled adaptor proteins).
NTR Binding (binds) of Nerve growth factor in Nerve associated with nerve growth factor and apoptosis
1) Confidence 0.33 Published 2008 Journal Novartis Found. Symp. Section Abstract Doc Link 18497106 Disease Relevance 0.15 Pain Relevance 0.24
Nerve growth factor (NGF) binds to TrkA receptors (neurotrophic) and P75(NTR) (apoptosis or other pathways depending on the coupled adaptor proteins).
NTR Binding (binds) of NGF in Nerve associated with nerve growth factor and apoptosis
2) Confidence 0.33 Published 2008 Journal Novartis Found. Symp. Section Abstract Doc Link 18497106 Disease Relevance 0.15 Pain Relevance 0.24
These data together suggest that pro-NGF, as well as mature NGF, binding to p75(NTR) plays an important role in inflammation-induced hyperalgesia.
NTR Binding (binding) of NGF associated with hyperalgesia, inflammation and nerve growth factor
3) Confidence 0.00 Published 2008 Journal J. Neurosci. Res. Section Abstract Doc Link 18709654 Disease Relevance 0.89 Pain Relevance 1.07
These data together suggest that pro-NGF, as well as mature NGF, binding to p75(NTR) plays an important role in inflammation-induced hyperalgesia.
NTR Binding (binding) of NGF associated with hyperalgesia, inflammation and nerve growth factor
4) Confidence 0.00 Published 2008 Journal J. Neurosci. Res. Section Abstract Doc Link 18709654 Disease Relevance 0.90 Pain Relevance 1.08

General Comments

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