INT15213

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Context Info
Confidence 0.67
First Reported 1986
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 3.86
Pain Relevance 5.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
head 3
ear skin 1
DMM 1
Htas2 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 9 100.00 Very High Very High Very High
Serotonin 6 100.00 Very High Very High Very High
Clonidine 5 100.00 Very High Very High Very High
substance P 8 99.74 Very High Very High Very High
antagonist 29 99.60 Very High Very High Very High
narcan 2 99.50 Very High Very High Very High
Pain 8 99.32 Very High Very High Very High
Antinociceptive 2 96.48 Very High Very High Very High
tail-flick 3 95.44 Very High Very High Very High
fluoxetine 4 94.92 High High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 8 100.00 Very High Very High Very High
Shock 8 99.98 Very High Very High Very High
Pruritus 4 99.58 Very High Very High Very High
Pain 2 99.32 Very High Very High Very High
Urological Neuroanatomy 3 99.28 Very High Very High Very High
Diabetes Mellitus 3 98.00 Very High Very High Very High
Non-diabetic Peripheral Neuropathy 1 97.76 Very High Very High Very High
Syndrome 2 97.60 Very High Very High Very High
Nociception 11 97.36 Very High Very High Very High
Disease 1 95.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study on the antinociceptive mechanism of action of tiapride (that blocks painful neuropathy in diabetic patients) has led us to hypothesize that the drug attenuates pain transmission through an indirect activation of central 5-HT1 and 5-HT2 receptors.
Positive_regulation (activation) of HT2 associated with pain, diabetes mellitus and antinociceptive
1) Confidence 0.67 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7562555 Disease Relevance 0.63 Pain Relevance 0.58
The data show that stimulation of 5-HT2 receptors, but not 5-HT1A receptors, induced a behavioural syndrome, which may reflect activation of nociceptive pathways.
Positive_regulation (stimulation) of HT2 associated with nociception and syndrome
2) Confidence 0.49 Published 1991 Journal Neuropharmacology Section Abstract Doc Link 1717872 Disease Relevance 0.41 Pain Relevance 0.36
Repeated administration of baclofen (10 mg/kg per day in drinking water) also increased the number of 5-HT2 receptors in the frontal cortex (16%) and enhanced the head-twitch behaviour after injection 5-HTP or 5-MeODMT.
Positive_regulation (increased) of HT2 in head associated with urological neuroanatomy
3) Confidence 0.49 Published 1986 Journal Neuropharmacology Section Abstract Doc Link 3018621 Disease Relevance 0.37 Pain Relevance 0.30
In contrast, repeated ECS increases both 5-HT2 receptor density and the head-twitch response, making it difficult to propose any simple hypothesis linking changes in this receptor with antidepressant activity.
Positive_regulation (increases) of HT2 in head associated with antidepressant and shock
4) Confidence 0.49 Published 1986 Journal Ciba Found. Symp. Section Abstract Doc Link 3028726 Disease Relevance 0.68 Pain Relevance 0.56
These results suggest that 5-HT released from mast cells is partly involved in the development of capsaicin-induced mouse ear edema via 5-HT2 receptors in the ear skin.
Positive_regulation (capsaicin-induced) of HT2 in ear skin associated with pressure and volume under development and qutenza
5) Confidence 0.49 Published 1995 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 8847833 Disease Relevance 0.64 Pain Relevance 0.92
On the other hand, these alpha2-adrenoceptor antagonists, at doses that had no effect on the basal number of head-twitches (idazoxan 0.2 mg/kg and yohimbine 0.5 mg/kg), significantly attenuated not only the suppressive effect of clonidine (0.01 mg/kg, IP) on head-twitch response but also that of the 5-HT2 receptor antagonist ritanserin (0.03 mg/kg, IP).
Positive_regulation (attenuated) of HT2 in head associated with antagonist and clonidine
6) Confidence 0.49 Published 1997 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9077577 Disease Relevance 0 Pain Relevance 0.67
Itch-associated response induced by intradermal serotonin through 5-HT2 receptors in mice.
Positive_regulation (induced) of HT2 associated with qutenza and serotonin
7) Confidence 0.49 Published 1999 Journal Neurosci. Res. Section Title Doc Link 10616911 Disease Relevance 0.36 Pain Relevance 0.63
-administered S-(+)-fenfluramine releases SP through the activation of 5-HT2 receptors subsequent to 5-HT release, and, as a result, produces nociceptive behavior.
Positive_regulation (activation) of HT2 associated with nociception and substance p
8) Confidence 0.49 Published 2007 Journal Neuropeptides Section Abstract Doc Link 17140659 Disease Relevance 0.42 Pain Relevance 0.51
Thus, 5-HT2 receptor activity in the DMM increases basal levels of airway dilation and ventilatory volume, dependent on central inspiratory activity and the volume threshold of the inspiratory off-switch mechanism.
Positive_regulation (increases) of HT2 in DMM
9) Confidence 0.49 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17537836 Disease Relevance 0.34 Pain Relevance 0.61

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