INT152151

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Context Info
Confidence 0.44
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.87
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome organization (Apc) plasma membrane (Apc) nucleus (Apc)
protein complex assembly (Apc) cytoplasm (Apc)
Apc (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 3 99.08 Very High Very High Very High
qutenza 11 91.24 High High
Piles 2 79.16 Quite High
addiction 2 40.04 Quite Low
agonist 8 23.28 Low Low
Cannabinoid 14 19.04 Low Low
Inflammation 10 5.00 Very Low Very Low Very Low
Pain 10 5.00 Very Low Very Low Very Low
Morphine 9 5.00 Very Low Very Low Very Low
Cannabinoid receptor 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 202 100.00 Very High Very High Very High
Adenoma 2 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 8 99.52 Very High Very High Very High
INFLAMMATION 9 98.88 Very High Very High Very High
Colon Cancer 5 97.04 Very High Very High Very High
Prostate Cancer 27 92.00 High High
Polyps 10 91.44 High High
Familial Adenomatous Polyposis 2 88.32 High High
Vomiting 76 83.36 Quite High
Disease 7 79.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sulindac treatment alters collagen and matrilysin expression in adenomas of ApcMin/+ mice.
Regulation (alters) of Gene_expression (expression) of Min associated with adenoma
1) Confidence 0.44 Published 2008 Journal Carcinogenesis Section Title Doc Link 18499699 Disease Relevance 0.82 Pain Relevance 0.20
The agency has requested further clinical data to support the efficacy claims in the Biologics License Application, as well as further information on the chemistry, manufacture and controls for APC8015 production.
Regulation (controls) of Gene_expression (production) of APC8015
2) Confidence 0.35 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503669 Disease Relevance 0.30 Pain Relevance 0
Effects of chronic Zangrado in ApcMin/+mice
Regulation (Effects) of Gene_expression (+mice) of ApcMin
3) Confidence 0.29 Published 2008 Journal J Transl Med Section Body Doc Link PMC2254379 Disease Relevance 0.96 Pain Relevance 0.22
The effect of ospemifene and tamoxifen on MIN-O tumorigenesis
Regulation (effect) of Gene_expression (tumorigenesis) of MIN-O associated with cancer
4) Confidence 0.06 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410776 Disease Relevance 1.79 Pain Relevance 0

General Comments

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