INT152153

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Context Info
Confidence 0.58
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.94
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp7) extracellular region (Mmp7) proteinaceous extracellular matrix (Mmp7)
Mmp7 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 12 100.00 Very High Very High Very High
fibrosis 45 98.48 Very High Very High Very High
agonist 44 97.36 Very High Very High Very High
Inflammation 25 87.92 High High
cINOD 17 77.68 Quite High
cytokine 17 5.00 Very Low Very Low Very Low
Inflammatory response 9 5.00 Very Low Very Low Very Low
Crohn's disease 9 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 118 100.00 Very High Very High Very High
Fibrosis 27 98.48 Very High Very High Very High
Pulmonary Fibrosis 21 95.48 Very High Very High Very High
Adenoma 16 94.84 High High
Colon Cancer 17 89.32 High High
Familial Adenomatous Polyposis 6 88.40 High High
INFLAMMATION 38 87.92 High High
Apoptosis 19 83.60 Quite High
Lung Cancer 2 81.84 Quite High
Colorectal Cancer 50 78.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Col1a2, Col5a2, Col6a2 and Col6a3, were upregulated, and matrilysin matrix metalloproteases-7 (Mmp7) was downregulated, in sulindac-treated mice.
Negative_regulation (downregulated) of matrilysin matrix metalloproteases-7
1) Confidence 0.58 Published 2008 Journal Carcinogenesis Section Abstract Doc Link 18499699 Disease Relevance 0.81 Pain Relevance 0.16
Col1a2, Col5a2, Col6a2 and Col6a3, were upregulated, and matrilysin matrix metalloproteases-7 (Mmp7) was downregulated, in sulindac-treated mice.
Negative_regulation (downregulated) of Mmp7
2) Confidence 0.58 Published 2008 Journal Carcinogenesis Section Abstract Doc Link 18499699 Disease Relevance 0.80 Pain Relevance 0.15
Mmp7 was found in 'hot spot' areas within the tumors of Apc(Min/+) mice treated with the vehicle, but was greatly diminished in those mice treated with sulindac.
Negative_regulation (diminished) of Mmp7 associated with cancer
3) Confidence 0.42 Published 2008 Journal Carcinogenesis Section Abstract Doc Link 18499699 Disease Relevance 0.76 Pain Relevance 0.18
After loss of E-cadherin, lysozyme and MMP7 positive cells were no longer confined to this location but were scattered all over the crypts and villi in Cre+Cdh1fl/fl mice (Fig. 3E and F, right panels).
Negative_regulation (loss) of MMP7
4) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0 Pain Relevance 0
cancer cells by downregulation of matrix metalloproteinase-7 (MMP-7) and
Negative_regulation (downregulation) of matrix metalloproteinase-7 associated with cancer and metalloproteinase
5) Confidence 0.24 Published 2008 Journal PPAR Research Section Body Doc Link PMC2422873 Disease Relevance 1.45 Pain Relevance 0.17
cancer cells by downregulation of matrix metalloproteinase-7 (MMP-7) and
Negative_regulation (downregulation) of MMP-7 associated with cancer and metalloproteinase
6) Confidence 0.24 Published 2008 Journal PPAR Research Section Body Doc Link PMC2422873 Disease Relevance 1.46 Pain Relevance 0.17
For instance, it has been documented that mice lacking MMP-7 are protected from bleomycin-induced fibrosis [16].
Negative_regulation (lacking) of MMP-7 associated with fibrosis
7) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2951918 Disease Relevance 0.67 Pain Relevance 0.39

General Comments

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