INT152155

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Context Info
Confidence 0.56
First Reported 2007
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 10.18
Pain Relevance 1.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Col1a2) extracellular region (Col1a2) proteinaceous extracellular matrix (Col1a2)
protein binding, bridging (Col1a2)
Anatomy Link Frequency
lung 3
ASM 1
CII 1
thickening 1
Col1a2 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 149 99.18 Very High Very High Very High
Acupuncture 57 97.96 Very High Very High Very High
Arthritis 48 97.92 Very High Very High Very High
Inflammation 80 94.44 High High
cytokine 21 84.72 Quite High
cINOD 3 79.96 Quite High
rheumatoid arthritis 19 76.32 Quite High
Inflammatory response 8 75.12 Quite High
chemokine 64 39.64 Quite Low
anesthesia 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Immunization 13 99.76 Very High Very High Very High
Asthma 104 99.20 Very High Very High Very High
Fibrosis 141 99.18 Very High Very High Very High
Respiratory Syncytial Virus 408 99.08 Very High Very High Very High
Arthritis 55 97.92 Very High Very High Very High
Adenoma 2 97.12 Very High Very High Very High
Autoimmune Disease 4 96.16 Very High Very High Very High
INFLAMMATION 68 94.44 High High
Cancer 8 93.20 High High
Sprains And Strains 5 92.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, V2O5 significantly increased total lung collagen levels as measured by Sircol assay, but not when mice were pre- or post-exposed to RSV (Fig. 3C).
Neg (not) Positive_regulation (increased) of collagen in lung associated with respiratory syncytial virus
1) Confidence 0.56 Published 2010 Journal Respir Res Section Body Doc Link PMC2841591 Disease Relevance 1.32 Pain Relevance 0.19
Airway fibrosis, increased airway wall thickness due to increased collagen and/or fibroblasts around the airways, as well as interstitial fibrotic lesions within the lung parenchyma, increased septal thickening due to collagen and/or fibroblasts in the alveolar region, was significantly increased by 21 days following a single intranasal exposure to V2O5 (Fig. 3A).
Positive_regulation (increased) of collagen in thickening associated with fibrosis
2) Confidence 0.56 Published 2010 Journal Respir Res Section Body Doc Link PMC2841591 Disease Relevance 1.22 Pain Relevance 0.09
Col1a2, Col5a2, Col6a2 and Col6a3, were upregulated, and matrilysin matrix metalloproteases-7 (Mmp7) was downregulated, in sulindac-treated mice.
Positive_regulation (upregulated) of Col1a2
3) Confidence 0.49 Published 2008 Journal Carcinogenesis Section Abstract Doc Link 18499699 Disease Relevance 0.80 Pain Relevance 0.16
Furthermore, V2O5 exposure alone significantly increased lung collagen, whereas we observed no significant increase in lung collagen in mice that received RSV before or after V2O5.
Neg (no) Positive_regulation (increase) of collagen in lung associated with respiratory syncytial virus
4) Confidence 0.37 Published 2010 Journal Respir Res Section Body Doc Link PMC2841591 Disease Relevance 2.06 Pain Relevance 0.23
Furthermore, V2O5 exposure alone significantly increased lung collagen, whereas we observed no significant increase in lung collagen in mice that received RSV before or after V2O5.
Positive_regulation (increased) of collagen in lung associated with respiratory syncytial virus
5) Confidence 0.37 Published 2010 Journal Respir Res Section Body Doc Link PMC2841591 Disease Relevance 2.12 Pain Relevance 0.23
In the present study, CII immunization remarkably increased collagen II antibody, IgG and IgM levels in mice serum, while EA at ST36 significantly reduced these levels in comparison with the control group or the NR group.
Positive_regulation (increased) of collagen II in CII associated with immunization and acupuncture
6) Confidence 0.03 Published 2007 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1810363 Disease Relevance 1.90 Pain Relevance 0.91
The ECM deposited by asthma derived ASM cells is altered such that increased amounts of collagen I and laminin [6], [7], [8], as well as fibronectin (FN) are produced which mediate a range of cellular interactions including migration, growth and differentiation.
Positive_regulation (increased) of collagen I in ASM associated with asthma
7) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 0.75 Pain Relevance 0.08

General Comments

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