INT152172

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Context Info
Confidence 0.58
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.18
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Camk4) nucleoplasm (Camk4) signal transduction (Camk4)
nucleocytoplasmic transport (Camk4) nucleus (Camk4) cytoplasm (Camk4)
Anatomy Link Frequency
nucleus accumbens 1
vesicle 1
dorsal horn 1
Camk4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 4 99.84 Very High Very High Very High
Dorsal horn 40 99.04 Very High Very High Very High
narcan 3 98.76 Very High Very High Very High
Eae 1 95.60 Very High Very High Very High
Spinal cord 148 94.00 High High
Opioid 1 88.24 High High
antagonist 1 87.96 High High
gABA 4 81.48 Quite High
Cannabinoid receptor 2 81.24 Quite High
potassium channel 2 78.44 Quite High
Disease Link Frequency Relevance Heat
Natriuresis 2 66.20 Quite High
Neuropathic Pain 20 62.08 Quite High
Pain 24 51.04 Quite High
Nociception 22 5.00 Very Low Very Low Very Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low
Nervous System Injury 2 5.00 Very Low Very Low Very Low
Volume Depletion And Dehydration 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic ethanol intake-induced changes in open-field behavior and calcium/calmodulin-dependent protein kinase IV expression in nucleus accumbens of rats: naloxone reversal.
Gene_expression (expression) of kinase IV in nucleus accumbens associated with nucleus accumbens and narcan
1) Confidence 0.58 Published 2008 Journal Acta Pharmacol. Sin. Section Title Doc Link 18501110 Disease Relevance 0 Pain Relevance 0.51
CAMK IV homolog seems to be broadly expressed in layers I-III of the dorsal horn (Fig. 2B).
Gene_expression (expressed) of CAMK IV in dorsal horn associated with dorsal horn
2) Confidence 0.19 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC126259 Disease Relevance 0.11 Pain Relevance 0.50
We found that the dorsally enriched genes also include several members of the calcium sensor protein family, such as vesicle associated calcium calmodulin binding protein (CAMK IV homolog), PKC?
Gene_expression (homolog) of CAMK IV in vesicle
3) Confidence 0.19 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC126259 Disease Relevance 0.07 Pain Relevance 0.60

General Comments

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