INT152174

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Context Info
Confidence 0.14
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 6.46
Pain Relevance 2.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Samsn1) nucleus (Samsn1)
Anatomy Link Frequency
liver 3
Samsn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 26 93.24 High High
imagery 16 91.20 High High
fibrosis 30 70.56 Quite High
Inflammation 11 67.12 Quite High
alcohol 10 59.08 Quite High
addiction 1 18.56 Low Low
Pain 3 5.00 Very Low Very Low Very Low
spastic colon 2 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nash(non-alcoholic Steatohepatitis) 35 100.00 Very High Very High Very High
Autoimmune Hepatitis 5 100.00 Very High Very High Very High
Fatty Liver 72 99.96 Very High Very High Very High
Hepatitis 26 99.92 Very High Very High Very High
Hepatic Encephalopathy 62 97.60 Very High Very High Very High
Liver Disease 48 97.08 Very High Very High Very High
Cirrhosis 115 93.52 High High
Hepatotoxicity 9 93.20 High High
Obesity 33 92.76 High High
Alcoholic Liver Diseases 18 92.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
F affects the partitioning of fatty acids toward their esterification, which has been shown in isolated perfused livers.48,49 In addition, F increases phosphofructokinase mRNA as well as G-6PDH and CHREB50 and fatty acid synthase activities.51 These effects lead to hepatic lipid loading, resulting in NASH (of which an HF diet is a relevant model in rats).
Negative_regulation (resulting) of NASH in livers associated with nash(non-alcoholic steatohepatitis)
1) Confidence 0.14 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2910863 Disease Relevance 0.37 Pain Relevance 0
The exact prevalence of NASH/NAFLD is not well established.
Negative_regulation (prevalence) of NASH associated with fatty liver and nash(non-alcoholic steatohepatitis)
2) Confidence 0.05 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697538 Disease Relevance 1.50 Pain Relevance 0.10
To investigate whether downregulation of PPARalpha in NASH is the critical mechanism of compromised liver tissue repair, PPARalpha was induced in steatohepatitic mice with clofibrate (250 mg/kg for 3 days, ip) before injecting APAP.
Spec (whether) Negative_regulation (downregulation) of NASH in liver associated with nash(non-alcoholic steatohepatitis) and paracetamol
3) Confidence 0.05 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18501395 Disease Relevance 0.83 Pain Relevance 0.97
PPARalpha was downregulated in NASH.
Negative_regulation (downregulated) of NASH associated with nash(non-alcoholic steatohepatitis)
4) Confidence 0.05 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18501395 Disease Relevance 0.83 Pain Relevance 0.96
In order to explore the potential effects of specific etiologies of liver disease on hepatic encephalopathy, patients with mixed etiologies or with etiologies represented in low numbers in the current cohort (i.e. hepatitis B, NASH, autoimmune hepatitis, and alpha 1-antithrypsine deficiency) were excluded from further analysis.
Negative_regulation (deficiency) of NASH in liver associated with liver disease, nash(non-alcoholic steatohepatitis), autoimmune hepatitis, hepatic encephalopathy and hepatitis
5) Confidence 0.04 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2575200 Disease Relevance 2.39 Pain Relevance 0.03
This is surprising as an elevated GGT is generally thought to be a serum marker of steatosis and elevated transaminases to be a marker of NASH.
Negative_regulation (marker) of NASH associated with nash(non-alcoholic steatohepatitis)
6) Confidence 0.02 Published 2005 Journal Comp Hepatol Section Body Doc Link PMC1327680 Disease Relevance 0.54 Pain Relevance 0.05

General Comments

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