INT152177

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.16
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Scn10a) transmembrane transport (Scn10a)
Scn10a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sodium channel 4 100.00 Very High Very High Very High
tetrodotoxin 1 100.00 Very High Very High Very High
Potency 1 91.60 High High
Bioavailability 1 90.48 High High
Neuropathic pain 2 85.84 High High
Mexiletine 1 74.96 Quite High
Lamotrigine 1 73.76 Quite High
neuralgia 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 2 85.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compounds were evaluated for their ability to block the tetrodotoxin-resistant sodium channel Na(v)1.8 (PN3) as well as the Na(v)1.2 and Na(v)1.5 subtypes.
Positive_regulation (evaluated) of Negative_regulation (block) of PN3 associated with tetrodotoxin and sodium channel
1) Confidence 0.43 Published 2008 Journal Bioorg. Med. Chem. Section Abstract Doc Link 18501613 Disease Relevance 0.16 Pain Relevance 0.60

General Comments

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