INT152221

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Context Info
Confidence 0.58
First Reported 2006
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 20
Disease Relevance 11.03
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (PRODH) small molecule metabolic process (PRODH) oxidoreductase activity (PRODH)
cellular nitrogen compound metabolic process (PRODH)
Anatomy Link Frequency
body 6
bile 1
dorsal root ganglia 1
PRODH (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 115 97.68 Very High Very High Very High
Bile 28 95.72 Very High Very High Very High
Pain 212 77.64 Quite High
agonist 140 62.84 Quite High
Analgesic 1 54.72 Quite High
postherpetic neuralgia 1 46.64 Quite Low
Fibrositis 14 36.48 Quite Low
cINOD 15 5.00 Very Low Very Low Very Low
qutenza 15 5.00 Very Low Very Low Very Low
COX-2 inhibitor 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mycobacterium Infection 112 99.80 Very High Very High Very High
Disease 2003 99.66 Very High Very High Very High
Herpes Zoster 9 99.50 Very High Very High Very High
Apoptosis 700 99.20 Very High Very High Very High
Colon Cancer 55 95.80 Very High Very High Very High
Ganglion Cysts 2 91.04 High High
Injury 15 88.32 High High
Stress 34 87.68 High High
Diabetes Mellitus 16 87.04 High High
Pain 212 77.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BACKGROUND: Herpes zoster (HZ), caused by varicella zoster virus (VZV), initially produces chicken-pox, then the virus lies dormant in the dorsal root ganglia.
Gene_expression (produces) of pox in dorsal root ganglia associated with herpes zoster
1) Confidence 0.58 Published 2008 Journal J Drugs Dermatol Section Abstract Doc Link 18505138 Disease Relevance 1.32 Pain Relevance 0.19
What do these cases tell us about the identifcation and classifcation of diseases in the Augsburg pox hospital, and in the early modern period in general?
Gene_expression (hospital) of pox associated with disease
2) Confidence 0.22 Published 2006 Journal Bull Hist Med Section Body Doc Link PMC2630158 Disease Relevance 0.67 Pain Relevance 0
It could point to the essence of the disease, but on no account was it the essence itself.48 Unfortunately, the archival documents do not give us a concrete and definite answer to what the hospital's medical practitioners believed to be the essence of the pox.
Gene_expression (essence) of pox associated with disease
3) Confidence 0.22 Published 2006 Journal Bull Hist Med Section Body Doc Link PMC2630158 Disease Relevance 0.44 Pain Relevance 0
The Ansbach physician Tobias Knobloch, for example, boasted that he had successfully detected and treated more than three hundred different species of the French disease during his medical career.61 The self-appointed pox specialist and surgeon Joseph Schmid claimed that the hunt for the pox and its physical signs in each patient's body required an extremely experienced healer (he was certainly describing himself), for the signs of the pox were innumerable and they easily “fooled” healer and patient alike.62
Gene_expression (hunt) of pox in body associated with disease
4) Confidence 0.22 Published 2006 Journal Bull Hist Med Section Body Doc Link PMC2630158 Disease Relevance 0.53 Pain Relevance 0
The Pox and the Body
Gene_expression (The) of Pox in Body
5) Confidence 0.22 Published 2006 Journal Bull Hist Med Section Body Doc Link PMC2630158 Disease Relevance 0.55 Pain Relevance 0.21
But knowledge of the universal nature of the pox was not only necessary for philosophical deductive demonstrations: as we shall see, it was also the precondition of all treatment in Augsburg's pox hospital.
Gene_expression (hospital) of pox
6) Confidence 0.22 Published 2006 Journal Bull Hist Med Section Body Doc Link PMC2630158 Disease Relevance 0.09 Pain Relevance 0
Although Hippocratic-Galenic medicine assumed some kind of relationship between bodily and functional damage, autopsy findings (and there is no evidence that postmortems were ever performed in Augsburg's pox hospital) were considered inconclusive regarding conditions in the undisturbed depths of the living body: the visible internal devastation of organs in a dead body would not be automatically understood as the disease's visible way through the living body.75 In fact, the pox circulated freely in corporeal space.
Gene_expression (hospital) of pox in body associated with disease
7) Confidence 0.22 Published 2006 Journal Bull Hist Med Section Body Doc Link PMC2630158 Disease Relevance 0.47 Pain Relevance 0
Von Hutten had firsthand experience with the pox: his body had been ravaged by it for more than nine years, until in 1519 he was miraculously cured in Augsburg by the new “wonder drug” guaiacum (a wood imported from the newly discovered West Indies).41 In a tract published after his recovery, he described how the nature of the French disease tried incessantly to overpower the nature of his body, which strove (sometimes with the help of medication) to expel the disease's poisonous material through its various orifices (skin pores, mouth, ears, nose, anus, etc.).42 For von Hutten, as for most of his contemporaries, external bodily signs such as the many lesions and ulcers that covered his body were not merely indicators of the invisible struggle going on inside the body between the nature of his body and its attacking disease(s); rather, they were accepted as proof that the body's nature had not yet submitted to the disease's sly onslaught.
Gene_expression (experience) of pox in body associated with ulcers and disease
8) Confidence 0.22 Published 2006 Journal Bull Hist Med Section Body Doc Link PMC2630158 Disease Relevance 0.73 Pain Relevance 0
This closeness could be explained, he argued, by the fact that they shared the same astrological ascendants.98 In the understanding of those present at Ess's examination, the pox and leprosy were separated only by the degree of their resemblance—and the degree to which they resembled each other was, as I have shown, largely a question of medical interpretation with the help of the patient.
Spec (examination) Gene_expression (examination) of pox associated with mycobacterium infection
9) Confidence 0.22 Published 2006 Journal Bull Hist Med Section Body Doc Link PMC2630158 Disease Relevance 0.83 Pain Relevance 0
What, then, turned a physical sign into a sign of the pox in the French-disease hospital?
Gene_expression (sign) of pox associated with disease
10) Confidence 0.22 Published 2006 Journal Bull Hist Med Section Body Doc Link PMC2630158 Disease Relevance 0.45 Pain Relevance 0
At the same time, the power of the invisible also was reflected in the overall institutional organization of the pox hospital, particularly in the hierarchical order of the appointed medical practitioners.
Gene_expression (hospital) of pox
11) Confidence 0.22 Published 2006 Journal Bull Hist Med Section Body Doc Link PMC2630158 Disease Relevance 0.23 Pain Relevance 0
Therefore it is little wonder that it heals those sick persons and diseases which are of a cold and humid nature,” wrote one of Germany's most prolific sixteenth-century medical writers, Walter Ryff.53 The early seventeenth-century Augsburg barber-surgeon Joseph Schmid, who had firsthand experience through his own work in the city's pox hospital, held a similar vision: guaiacum warms and dries out the bodily humors, making them thin and fluid, he explained, so that they can then be easily expelled from the body.54
Gene_expression (hospital) of pox in body associated with disease
12) Confidence 0.22 Published 2006 Journal Bull Hist Med Section Body Doc Link PMC2630158 Disease Relevance 0.42 Pain Relevance 0
In Hippocratic-Galenic medicine, which reigned paramount in the pox hospital until far into the seventeenth century, the four humors—blood (hot and wet), phlegm (cold and wet), black bile (cold and dry), and yellow bile (hot and dry)—were the body's primary elements, and were seen as more important than its solid organs: they regulated all the body's physiological functions and were believed to be fused in the blood (the actual fluid found in the veins) and to be “concocted” from food in the liver.46
Gene_expression (hospital) of pox in bile associated with bile
13) Confidence 0.22 Published 2006 Journal Bull Hist Med Section Body Doc Link PMC2630158 Disease Relevance 0.17 Pain Relevance 0.10
This closeness could be explained, he argued, by the fact that they shared the same astrological ascendants.98 In the understanding of those present at Ess's examination, the pox and leprosy were separated only by the degree of their resemblance—and the degree to which they resembled each other was, as I have shown, largely a question of medical interpretation with the help of the patient.
Gene_expression (present) of pox associated with mycobacterium infection
14) Confidence 0.22 Published 2006 Journal Bull Hist Med Section Body Doc Link PMC2630158 Disease Relevance 0.83 Pain Relevance 0
The Ansbach physician Tobias Knobloch, for example, boasted that he had successfully detected and treated more than three hundred different species of the French disease during his medical career.61 The self-appointed pox specialist and surgeon Joseph Schmid claimed that the hunt for the pox and its physical signs in each patient's body required an extremely experienced healer (he was certainly describing himself), for the signs of the pox were innumerable and they easily “fooled” healer and patient alike.62
Gene_expression (signs) of pox in body associated with disease
15) Confidence 0.22 Published 2006 Journal Bull Hist Med Section Body Doc Link PMC2630158 Disease Relevance 0.51 Pain Relevance 0
the POX promoter, and increased endogenous POX expression.
Gene_expression (expression) of POX promoter
16) Confidence 0.16 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 0.66 Pain Relevance 0.08
the POX promoter, and increased endogenous POX expression.
Gene_expression (expression) of POX
17) Confidence 0.16 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 0.65 Pain Relevance 0.08
GW9662 or deletion of the PPAR-responsive element in the POX promoter only
Gene_expression (only) of POX promoter
18) Confidence 0.14 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 0.62 Pain Relevance 0.08
targeting POX gene expression for generation of ROS.

2.2.

Gene_expression (expression) of POX gene
19) Confidence 0.13 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 0.40 Pain Relevance 0.03
are involved in the troglitazone-induced POX expression [17].
Gene_expression (expression) of POX
20) Confidence 0.13 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 0.45 Pain Relevance 0.04

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