INT152223

Context Info Confidence 0.29 First Reported 2001 Last Reported 2009 Negated 1 Speculated 0 Reported most in Body Documents 10 Total Number 10 Disease Relevance 6.67 Pain Relevance 1.46

cytosol (BEST1) plasma membrane (BEST1)

Anatomy Link Frequency visceral 1 BEST1 (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 30 99.92 opiate 4 91.12 visual analogue scale 5 85.36 methotrexate 3 79.68 cocaine 1 73.48 Antiemetics 1 67.16 rheumatoid arthritis 49 50.00 spastic colon 2 50.00 Arthritis 14 47.12 antagonist 2 41.28

Disease Link Frequency Relevance Heat Disease 159 100.00 Pain 19 99.92 Reprotox - General 2 7 99.76 Syndrome 13 99.14 Thalassemia 24 98.94 Functional Bowel Disorder 2 98.72 Bone Cancer 6 98.12 Leishmaniasis 11 96.68 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super 2 95.76 African Trypanosomiasis 16 92.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

BMD was negatively associated with fractures but not with bone pain.

BMD Binding (associated) of associated with pain

1) Confidence 0.29 Published 2009 Journal J. Bone Miner. Res. Section Abstract Doc Link 18505376 Disease Relevance 1.36 Pain Relevance 0.37

The purpose of this study was to determine the prevalence of low BMD, fractures, and bone pain in all thalassemia syndromes in childhood, adolescence, and adulthood, associations of BMD with fractures and bone pain, and etiology of bone disease in thalassemia.

BMD Binding (associations) of associated with pain, syndrome, thalassemia and bone cancer

2) Confidence 0.23 Published 2009 Journal J. Bone Miner. Res. Section Abstract Doc Link 18505376 Disease Relevance 1.27 Pain Relevance 0.29

Low BMD is associated with hypogonadism, increased bone turnover, and an increased risk for fractures.

BMD Binding (associated) of associated with reprotox - general 2

3) Confidence 0.23 Published 2009 Journal J. Bone Miner. Res. Section Abstract Doc Link 18505376 Disease Relevance 0.83 Pain Relevance 0.17

Moreover, drug–food, drug–disease and drug–diagnostics interactions have to be considered that are, however, beyond the scope of this article.

disease Binding (interactions) of associated with disease

4) Confidence 0.07 Published 2007 Journal Pharm World Sci Section Body Doc Link PMC2253652 Disease Relevance 0.60 Pain Relevance 0.03

Disease activity

Disease Binding (activity) of associated with disease

5) Confidence 0.03 Published 2001 Journal Arthritis Res Section Body Doc Link PMC34114 Disease Relevance 0.60 Pain Relevance 0

METHODS: The IBS-QOL and BEST index were administered to 71 patients with IBS twice: before and after treatment.

BEST Binding (index) of

6) Confidence 0.02 Published 2008 Journal Eksp Klin Gastroenterol Section Body Doc Link 19334419 Disease Relevance 0.10 Pain Relevance 0

Disease activity

Disease Binding (activity) of associated with disease

7) Confidence 0.02 Published 2009 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2656634 Disease Relevance 0.35 Pain Relevance 0.24

Disease activity

Disease Binding (activity) of associated with disease

8) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656227 Disease Relevance 0.26 Pain Relevance 0.08

The formula used to calculate the attributable risk fraction has been judged to be suitable when no confounding of the exposure-disease association exists,18 but we cannot explore the possibility of such confounding in these data.

exposure-disease Neg (no) Binding (association) of associated with disease

9) Confidence 0.01 Published 2008 Journal BMJ : British Medical Journal Section Body Doc Link PMC2500201 Disease Relevance 0.10 Pain Relevance 0.28

Both visceral and cutaneous forms occur in SSA, with the former producing serious disease associated with high mortality.

disease Binding (associated) of in visceral associated with disease

10) Confidence 0.01 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2727001 Disease Relevance 1.11 Pain Relevance 0

General Comments

This test has worked.