INT152225

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Context Info
Confidence 0.53
First Reported 2007
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 2.50
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4) plasma membrane (Tlr4) intracellular (Tlr4)
cytoplasm (Tlr4)
Anatomy Link Frequency
macrophages 4
embryo 2
C8-B4 2
bladder 2
Kupffer cells 2
Tlr4 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 6 100.00 Very High Very High Very High
antagonist 11 96.12 Very High Very High Very High
sodium channel 8 93.60 High High
Inflammation 51 93.52 High High
cytokine 101 93.40 High High
antidepressant 35 93.28 High High
Neuropathic pain 9 89.44 High High
Inflammatory response 15 74.60 Quite High
tetrodotoxin 1 71.52 Quite High
chemokine 5 61.68 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 71 100.00 Very High Very High Very High
Shock 17 99.24 Very High Very High Very High
Embryo Loss 18 99.00 Very High Very High Very High
Overactive Bladder 18 98.82 Very High Very High Very High
Spontaneous Abortion 68 98.46 Very High Very High Very High
Neuropathic Pain 11 89.44 High High
Adult Respiratory Distress Syndrome 4 86.88 High High
Endotoxemia 14 85.92 High High
Sepsis 56 85.36 High High
Targeted Disruption 2 84.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data demonstrate that lignocaine has significant inhibitory effects on the activation of TLR-4, NF-kappaB and MAPKs in activated macrophages.
Regulation (effects) of Positive_regulation (activation) of TLR-4 in macrophages
1) Confidence 0.53 Published 2008 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 18505446 Disease Relevance 0 Pain Relevance 0.29
Even at concentrations up to 10 ยตM, catechin or ethyl gallate did not affect LPS-induced HMGB1 release (Fig. 4B), indicating that functional groups of both catechin and gallate are needed for EGCG's HMGB1-inhibiting properties.


Regulation (affect) of Positive_regulation (induced) of LPS
2) Confidence 0.28 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.16 Pain Relevance 0.03
PGE2 responses in Kupffer cells stimulated with LPS
Regulation (responses) of Positive_regulation (stimulated) of LPS in Kupffer cells
3) Confidence 0.27 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2243250 Disease Relevance 0 Pain Relevance 0
In fact, the effect of MA was equal to (and not additive with) that of LPS activation, strongly suggesting that the P2X receptors that are up-regulated during the activated state of C8-B4 cells originate from lysosomes.


Regulation (regulated) of Neg (not) Positive_regulation (activation) of LPS in C8-B4
4) Confidence 0.18 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0.23 Pain Relevance 0.32
In order to determine the differences in bladder mucosa and detrusor gene regulation in response to BCG in comparison to those elicited by other inflammatory stimuli (LPS and TNF-?)
Regulation (elicited) of Positive_regulation (stimuli) of LPS in bladder associated with overactive bladder and inflammatory stimuli
5) Confidence 0.12 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.95 Pain Relevance 0.30
These results indicate that Que or BA alone has a protective effect on LPS-induced IFN-?
Regulation (effect) of Positive_regulation (induced) of LPS
6) Confidence 0.11 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2958556 Disease Relevance 0.23 Pain Relevance 0
In the present study, both abortion rate and embryo resorption rate reached 100% (P < .01) after an intravenous injection of LPS via the lateral tail vein at a dose of 0.2?
Regulation (lateral) of Positive_regulation (injection) of LPS in embryo associated with embryo loss and spontaneous abortion
7) Confidence 0.11 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2958556 Disease Relevance 0.50 Pain Relevance 0.03
levels after LPS challenge, it is suggested that MT induction is not involved in the protective effect of PZ on LPS-induced endotoxin shock in our experimental model.
Neg (not) Regulation (involved) of Positive_regulation (effect) of LPS associated with shock
8) Confidence 0.11 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872229 Disease Relevance 0.36 Pain Relevance 0.05
Down-regulation of P2RY5 in response to a macrophage activating stimulus such as LPS might remove this inhibitory effect, thus allowing activated macrophages to respond to nucleotides.
Regulation (regulation) of Positive_regulation (response) of LPS in macrophages
9) Confidence 0.07 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.07 Pain Relevance 0.11

General Comments

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