INT152229

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.29
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4) plasma membrane (Tlr4) intracellular (Tlr4)
cytoplasm (Tlr4)
Anatomy Link Frequency
macrophages 2
Tlr4 (Mus musculus)
Pain Link Frequency Relevance Heat
sodium channel 7 92.64 High High
tolerance 42 90.88 High High
tetrodotoxin 1 88.72 High High
Inflammatory response 1 64.44 Quite High
Inflammation 8 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 3 96.84 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 1 67.92 Quite High
Sepsis 11 65.00 Quite High
INFLAMMATION 10 64.08 Quite High
Infection 5 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Bacterial Infection 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that LPS significantly increased the concentrations of TLR-4, NF-kappaB and MAPKs, including extracellular regulated kinase (ERK), c-jun N-terminal kinase (JNK) and p38 MAPK, in activated macrophages.
Positive_regulation (increased) of Regulation (concentrations) of TLR-4 in macrophages
1) Confidence 0.40 Published 2008 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 18505446 Disease Relevance 0.13 Pain Relevance 0.39
Nevertheless, the elimination of SOCS-1 alone did not restore LPS responsiveness in tolerant MEFs.
Neg (not) Positive_regulation (restore) of Regulation (responsiveness) of LPS
2) Confidence 0.23 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0.16 Pain Relevance 0.08

General Comments

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