INT152236

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Context Info
Confidence 0.19
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.64
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4, Nos2) intracellular (Tlr4, Nos2) cytoplasm (Tlr4, Nos2)
cytosol (Nos2) extracellular space (Nos2) oxidoreductase activity (Nos2)
Anatomy Link Frequency
lung 2
Tlr4 (Mus musculus)
Nos2 (Mus musculus)
Pain Link Frequency Relevance Heat
sodium channel 14 99.88 Very High Very High Very High
Inflammatory response 2 97.00 Very High Very High Very High
cva 1 85.44 High High
Inflammation 5 82.64 Quite High
tetrodotoxin 2 71.20 Quite High
cytokine 13 23.44 Low Low
Paracetamol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sepsis 3 97.56 Very High Very High Very High
INFLAMMATION 6 96.64 Very High Very High Very High
Hemorrhage 1 85.44 High High
Pressure And Volume Under Development 1 84.20 Quite High
Body Weight 3 23.64 Low Low
Shock 14 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low
Adult Respiratory Distress Syndrome 4 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Multiple Organ Failure 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Toll-like receptor-4 (TLR-4), nuclear factor (NF)-kappaB and mitogen activated protein kinases (MAPKs) participate in the upstream regulation of iNOS expression induced by endotoxin.
TLR-4 Regulation (regulation) of Gene_expression (expression) of iNOS
1) Confidence 0.19 Published 2008 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 18505446 Disease Relevance 0.19 Pain Relevance 0.37
Toll-like receptor-4 (TLR-4), nuclear factor (NF)-kappaB and mitogen activated protein kinases (MAPKs) participate in the upstream regulation of iNOS expression induced by endotoxin.
Toll-like receptor-4 Regulation (regulation) of Gene_expression (expression) of iNOS
2) Confidence 0.19 Published 2008 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 18505446 Disease Relevance 0.19 Pain Relevance 0.37
Effect of PZ pretreatment on iNOS gene expression in mouse lung after LPS
LPS Regulation (Effect) of Gene_expression (expression) of iNOS in lung
3) Confidence 0.05 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872229 Disease Relevance 0.25 Pain Relevance 0.08

General Comments

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