INT152255

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Context Info
Confidence 0.71
First Reported 2005
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 14
Total Number 17
Disease Relevance 12.53
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ATM) signal transduction (ATM) cell death (ATM)
cytoplasmic membrane-bounded vesicle (ATM) nucleus (ATM) DNA binding (ATM)
Anatomy Link Frequency
neurons 1
brain 1
band 1
TEK 1
ATM (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 31 100.00 Very High Very High Very High
metalloproteinase 12 100.00 Very High Very High Very High
antagonist 6 99.20 Very High Very High Very High
imagery 21 97.36 Very High Very High Very High
Inflammation 18 93.68 High High
Hippocampus 34 92.84 High High
headache 4 90.16 High High
Spinal cord 8 85.12 High High
Pyramidal cell 4 82.88 Quite High
Snapping jaw 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Thyroid Neoplasm 169 100.00 Very High Very High Very High
Insulin Resistance 103 100.00 Very High Very High Very High
Ataxia 31 100.00 Very High Very High Very High
Thrombosis 23 100.00 Very High Very High Very High
Pancreatic Cancer 36 99.84 Very High Very High Very High
Birth Weight 11 99.80 Very High Very High Very High
Disease 574 99.46 Very High Very High Very High
Death 69 97.68 Very High Very High Very High
Cancer 317 97.44 Very High Very High Very High
Colon Cancer 63 96.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ataxia telangiectasia, a rare disorder characterized by degeneration of the brain region that controls movement and speech, occurs when both copies of the ATM gene (human cells contain two copies of most genes) contain a genetic change that stops the production of functional ATM protein.
Gene_expression (production) of ATM in brain associated with ataxia
1) Confidence 0.71 Published 2009 Journal PLoS Medicine Section Abstract Doc Link PMC2642879 Disease Relevance 0.93 Pain Relevance 0.26
-act cga gcg gtt ttt ctt aac atc-3?
Gene_expression (ttt) of atc
2) Confidence 0.65 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0 Pain Relevance 0
Nottingham, NG7 2HA, UK

+44 (0)115 8230813 (tel) +44 (0)115 8231208 (fax)

Gene_expression (Nottingham) of tel
3) Confidence 0.65 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2913927 Disease Relevance 0.21 Pain Relevance 0
-act cga gcg gtt ttt ctt aac atc-3?
Gene_expression (ctt) of atc
4) Confidence 0.65 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0 Pain Relevance 0
As a result the relation between maternal insulin resistance and birth weight should be stronger and steeper for male than for female infants.
Gene_expression (resistance) of ate associated with birth weight and insulin resistance
5) Confidence 0.65 Published 2007 Journal BMC Evol Biol Section Body Doc Link PMC1868084 Disease Relevance 1.08 Pain Relevance 0
RESULTS: Neuromyelitis optica-IgG was detected in six of 10 NMO patients (60%), six of 10 idiopathic relapsing transverse myelitis (IRTM) patients (60%), two of nine idiopathic relapsing ON patients (22%), one of 11 patients (9%) having single ON attack, one of 30 CMS patients (3%), and none of patients having single ATM attack or controls.
Gene_expression (attack) of ATM
6) Confidence 0.65 Published 2009 Journal Eur. J. Neurol. Section Body Doc Link 19138340 Disease Relevance 0.24 Pain Relevance 0
On the other hand, right branch shows overexpression areas with genes such as CASP 10, CD30-L, and CD-40-L (TNF family), ras-like small, FGF 3 and 5, TDGF1, ERK5, MIF, IFNGR2, MIG, IFN-alpha, beta, gamma, IL-3, -4, -9 and -13, IP-10, HPRT, DCC, TEK, netrin-2, cadherins 4, 8, 12 and 13 [33], MMP3, 8, 10, 12 and 13 (metalloproteinase), COL11A2, CCNG1, CDC-6, ATM, N-MYC, and p53.
Gene_expression (overexpression) of ATM in TEK associated with metalloproteinase
7) Confidence 0.48 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.90 Pain Relevance 0.05
ATM Ataxia telangiectasia
Gene_expression (telangiectasia) of ATM associated with ataxia
8) Confidence 0.46 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 1.25 Pain Relevance 0.10
In the last decade, the advancement of molecular biology improved the understanding of the pathogenesis of pancreatic cancer and characterized a number of genes that mutated in pancreatic cancers, such as somatic mutations in genes INK4A(CDKN2A), TP53, DPC4, BRCA1/2, STK11, APC, KRAS and ATM and PALB2 are found in pancreatic cancers [10]–[18].
Gene_expression (found) of ATM associated with pancreatic cancer
9) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912284 Disease Relevance 1.36 Pain Relevance 0.07
The cell cycle marker cyclin A (Figure 3 red arrow) and the DNA damage marker 53BP1 (Figure 3 black arrow) and P-ATM (Figure 3 blue arrow) were consistently found in different CDN neurons.
Gene_expression (found) of P-ATM in neurons
10) Confidence 0.41 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3018387 Disease Relevance 0.24 Pain Relevance 0.09
To determine whether the 53BP1 response was reflective of a broader ATM-dependent response to DNA damage, we examined ATM auto-phosphorylation with a phospho-ser1981 specific antibody (Figure 2C, D).
Spec (whether) Gene_expression (response) of ATM
11) Confidence 0.41 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3018387 Disease Relevance 0.75 Pain Relevance 0
Three cases (2 AD, 1 control) had extensive P-ATM staining but were not immunoreactive to 53BP1 antibody.
Gene_expression (staining) of P-ATM associated with disease
12) Confidence 0.41 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3018387 Disease Relevance 0.61 Pain Relevance 0
However, this case stained negative for DNA damage response markers 53BP1 and P-ATM.
Neg (negative) Gene_expression (negative) of P-ATM
13) Confidence 0.36 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3018387 Disease Relevance 0.70 Pain Relevance 0.03
Diagnosis of ATC
Gene_expression (Diagnosis) of ATC associated with thyroid neoplasm
14) Confidence 0.18 Published 2010 Journal Journal of Thyroid Research Section Body Doc Link PMC2956973 Disease Relevance 2.05 Pain Relevance 0
ate, iso1, iso10 with respect to the ctr group.
Gene_expression (group) of ate
15) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722085 Disease Relevance 0.59 Pain Relevance 0
Analysis of thrombotic events in the BRiTE registry showed a similar risk of developing ATE in patients < 65 years old compared with patients in the age group of 65 to 74 years (1.5%), though the rate was higher in patients older then 75 years of age (4.1%).94
Gene_expression (developing) of ATE associated with cva
16) Confidence 0.11 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886334 Disease Relevance 0.90 Pain Relevance 0.51
Detection of RANKL and OPG in ATDC5 and expression of both in HFLS was confirmed with complete disappearance of the RANKL band, and marked increase in the expression of OPG after 1 h from the addition of estrogen.
Gene_expression (expression) of ATDC5 in band
17) Confidence 0.03 Published 2008 Journal Int. J. Mol. Med. Section Abstract Doc Link 18506373 Disease Relevance 0.71 Pain Relevance 0.16

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