INT152262

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.22
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (FASN) small molecule metabolic process (FASN) lyase activity (FASN)
Golgi apparatus (FASN) cytoplasm (FASN) cytosol (FASN)
Anatomy Link Frequency
fat 1
TMJ 1
FASN (Homo sapiens)
Pain Link Frequency Relevance Heat
local anesthetic 11 91.40 High High
cytokine 10 50.00 Quite Low
Snapping jaw 2 50.00 Quite Low
Osteoarthritis 2 50.00 Quite Low
psoriasis 3 15.04 Low Low
endometriosis 3 14.44 Low Low
medulla 4 14.24 Low Low
Arthritis 3 13.84 Low Low
fibrosis 4 5.60 Low Low
Inflammation 21 5.08 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 7 96.88 Very High Very High Very High
Cancer 137 94.12 High High
Disease 19 89.28 High High
Hypertrophy 2 86.24 High High
Restenosis 1 78.40 Quite High
Renal Failure 5 75.00 Quite High
Body Weight 4 60.40 Quite High
Shock 3 57.84 Quite High
Liver Cancer 2 53.16 Quite High
Carcinoma 5 53.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among all these agents, perhaps the most remarkable is metformin, which on targeting AMPK could be at least as – if not more – effective than mTOR, Fatty acid synthase, and mevalonate pathway inhibitors.
Positive_regulation (effective) of Fatty acid synthase
1) Confidence 0.32 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.74 Pain Relevance 0.09
Relevant mechanisms embrace repression of insulin-sensitizing genes, such as adiponectin, and induction of adipocyte leptin and peroxisome-proliferating activator receptor- (PPAR-) gamma genes; stimulation of endothelial lipoprotein lipase, adipocyte fatty acid synthase, acetyl CoA carboxylase, and fat-cell glucose uptake; and inhibition of fat oxidation via rate-limiting carnitine-palmitoyl transferase [167, 171, 172, 191, 554, 555].
Positive_regulation (stimulation) of fatty acid synthase in fat associated with repression
2) Confidence 0.03 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.43 Pain Relevance 0
Furthermore, an inflammatory response characterised by the predominant expression of IL12 mRNA and down-regulated expression of IL10 mRNA is associated with the degenerative changes observed in OA-TMJ.


Positive_regulation (changes) of OA-TMJ in TMJ
3) Confidence 0.00 Published 2008 Journal Arch. Oral Biol. Section Body Doc Link 18508030 Disease Relevance 0.05 Pain Relevance 0

General Comments

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