INT152286

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.95
Pain Relevance 2.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp9) extracellular space (Mmp9) aging (Mmp9)
extracellular region (Mmp9) proteinaceous extracellular matrix (Mmp9) extracellular matrix organization (Mmp9)
Anatomy Link Frequency
endothelial cells 3
leukocyte 2
extracellular matrix 2
hippocampus 2
neutrophils 1
Mmp9 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 45 100.00 Very High Very High Very High
antidepressant 9 100.00 Very High Very High Very High
fluoxetine 1 100.00 Very High Very High Very High
Desipramine 1 100.00 Very High Very High Very High
Hippocampus 13 99.08 Very High Very High Very High
Spinal cord 30 98.28 Very High Very High Very High
ischemia 107 89.56 High High
Kinase C 10 78.32 Quite High
chemokine 8 75.12 Quite High
cytokine 19 74.52 Quite High
Disease Link Frequency Relevance Heat
Convulsion 1 100.00 Very High Very High Very High
Diabetes Mellitus 29 99.34 Very High Very High Very High
Multiple Sclerosis 132 99.02 Very High Very High Very High
Uterine Fibroids 1 98.36 Very High Very High Very High
Congenital Anomalies 12 98.22 Very High Very High Very High
Stress 95 97.28 Very High Very High Very High
Urological Neuroanatomy 10 95.94 Very High Very High Very High
Demyelinating Disease 5 94.00 High High
Cerebral Infarction 10 89.56 High High
Cv Unclassified Under Development 101 88.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The influence of distinct classes of antidepressants, namely, electroconvulsive seizure, fluoxetine, tranylcypromine, and desipramine, on the gene expression of MMP-2, MMP-9, and TIMPs 1-4 in the hippocampus was determined using radioactive in situ hybridization.
Spec (determined) Regulation (influence) of Gene_expression (expression) of MMP-9 in hippocampus associated with desipramine, antidepressant, convulsion, hippocampus and fluoxetine
1) Confidence 0.36 Published 2008 Journal Synapse Section Abstract Doc Link 18509851 Disease Relevance 0.18 Pain Relevance 0.77
There are multiple factors implicated in vascular abnormalities under diabetic conditions.31 The matrix in the diabetic vascular wall is altered due to changes in MMP2 and MMP9 expression resulting in an increase in accumulated fibroid substances, which may participate in adversely affecting vascular activity.12,16 The intercellular gap junction connexin proteins are important for maintaining normal vascular tone through passing small molecules between cells, among which Cx40 (connexin 40) is active in the vascular wall and its downregulation results in a compromised pulmonary vascular dilatation.12 Drug intervention normalizes the abnormal Cx43, leading to a recovery of the cardiovascular abnormalities.22 An activated PKC?
Regulation (changes) of Gene_expression (expression) of MMP9 associated with kinase c, uterine fibroids, diabetes mellitus, congenital anomalies, hepatopulmonary syndrome and cardiovascular disorder under development
2) Confidence 0.29 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941789 Disease Relevance 0.77 Pain Relevance 0.13
The EAE group showed enhanced MPO activity compared to the control group (9,66 ± 1,59 vs 5,59 ± 0,42 mU/min.mg protein respectively: see figure 2B; F: 6,708, dF: 15) while no increase in MPO activity was observed in the EAE group submitted to chronic stress, indicating leukocyte infiltration in spinal cord of the EAE group, but not of the EAE+S group, which could be directly related to the effects on MMP-9 expression above mentioned.
Regulation (effects) of Gene_expression (expression) of MMP-9 in leukocyte associated with stress, multiple sclerosis, urological neuroanatomy and spinal cord
3) Confidence 0.20 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2958904 Disease Relevance 1.85 Pain Relevance 0.26
In vivo, MMP-2 expression increased in astrocytic endfeet of rats exposed to MCAO, while MMP-9 expression was localized to neutrophils and endothelial cells [22].
Regulation (localized) of Gene_expression (expression) of MMP-9 in endothelial cells
4) Confidence 0.10 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2527306 Disease Relevance 0.55 Pain Relevance 0.44
More recent studies have shown that NO generated from iNOS activity modulates the expression of matrix metalloproteinase-9 (MMP-9), an enzyme responsible for degradation of extracellular matrix, which significantly influenced cell migration [21].
Regulation (modulates) of Gene_expression (expression) of matrix metalloproteinase-9 in extracellular matrix associated with metalloproteinase
5) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0.06 Pain Relevance 0.11
In vivo, MMP-2 expression increased in astrocytic endfeet of rats exposed to MCAO, while MMP-9 expression was localized to neutrophils and endothelial cells [22].
Regulation (localized) of in neutrophils Gene_expression (expression) of MMP-9 in endothelial cells
6) Confidence 0.04 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2527306 Disease Relevance 0.55 Pain Relevance 0.44

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