INT15229

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Context Info
Confidence 0.69
First Reported 1980
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 21
Total Number 21
Disease Relevance 15.86
Pain Relevance 4.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CNDP1) extracellular region (CNDP1)
Anatomy Link Frequency
liver 3
thyroid 1
parathyroid 1
urine 1
CNDP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 12 99.82 Very High Very High Very High
Angina 2 99.82 Very High Very High Very High
headache 14 99.34 Very High Very High Very High
Pain 10 99.10 Very High Very High Very High
Sciatic nerve 2 97.92 Very High Very High Very High
peripheral neuropathy 5 97.52 Very High Very High Very High
Etanercept 8 97.12 Very High Very High Very High
pruritus 1 96.76 Very High Very High Very High
abdominal pain 10 94.84 High High
aspirin 21 92.64 High High
Disease Link Frequency Relevance Heat
Disorders Of Creatine Metabolism 7 100.00 Very High Very High Very High
Disease 18 99.96 Very High Very High Very High
Hyperbilirubinemia 2 99.96 Very High Very High Very High
Rhabdomyolysis 8 99.92 Very High Very High Very High
Congenital Anomalies 11 99.88 Very High Very High Very High
Cv General 3 Under Development 3 99.82 Very High Very High Very High
Thrombocytopenia 1 99.64 Very High Very High Very High
Pressure And Volume Under Development 7 99.56 Very High Very High Very High
Jaundice 3 99.56 Very High Very High Very High
Necrosis 4 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Excessive elevation of serum creatine phosphokinase indicated the presence of rhabdomyolysis.
Positive_regulation (elevation) of serum creatine phosphokinase associated with disorders of creatine metabolism and rhabdomyolysis
1) Confidence 0.69 Published 1997 Journal Neurology Section Abstract Doc Link 9008535 Disease Relevance 0.80 Pain Relevance 0.19
His laboratory findings showed abnormally elevated serum creatine phosphokinase and myoglobin but normal thyroid hormone levels.
Positive_regulation (elevated) of serum creatine phosphokinase in thyroid associated with disorders of creatine metabolism
2) Confidence 0.43 Published 2001 Journal Endocr. J. Section Abstract Doc Link 11456272 Disease Relevance 1.10 Pain Relevance 0.29
Serum liver enzyme levels were moderately to markedly elevated.
Positive_regulation (elevated) of Serum liver enzyme in liver
3) Confidence 0.38 Published 1991 Journal Arch. Pathol. Lab. Med. Section Abstract Doc Link 1718242 Disease Relevance 0.68 Pain Relevance 0.19
We suspected not only hemolysis by the color of the serum and the blood chemistry, but also rhabdomyolysis by increased levels of serum creatine phosphokinase and myoglobin as well as urine myoglobin.
Positive_regulation (increased) of serum creatine phosphokinase in urine associated with disorders of creatine metabolism, rhabdomyolysis and hemolysis
4) Confidence 0.15 Published 2010 Journal Masui Section Abstract Doc Link 20662298 Disease Relevance 1.19 Pain Relevance 0.32
Asymptomatic elevations of the serum aminotransferase levels (in 13 patients) and the serum urate level (in 10) were also noted, but there was no dose-related hematologic toxicity.
Positive_regulation (elevations) of serum aminotransferase associated with toxicity
5) Confidence 0.09 Published 1990 Journal N. Engl. J. Med. Section Abstract Doc Link 2139173 Disease Relevance 1.16 Pain Relevance 0.15
This acute febrile illness is characterized by myalgias, headache, thrombocytopenia, and elevated serum aminotransferase levels.
Positive_regulation (elevated) of serum aminotransferase associated with thrombocytopenia, headache and disease
6) Confidence 0.09 Published 1996 Journal N. Engl. J. Med. Section Abstract Doc Link 8531996 Disease Relevance 0.66 Pain Relevance 0.10
Serum creatine phosphokinase was markedly elevated and returned to normal after treatment.
Positive_regulation (elevated) of Serum creatine phosphokinase associated with disorders of creatine metabolism
7) Confidence 0.07 Published 1986 Journal Am. J. Gastroenterol. Section Abstract Doc Link 2872796 Disease Relevance 0.98 Pain Relevance 0.17
Serum levels of parathyroid hormone-related peptide, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha and total serum receptor activator of nuclear factor kappaB ligand were not elevated.
Neg (not) Positive_regulation (elevated) of serum receptor in parathyroid associated with necrosis and cancer
8) Confidence 0.03 Published 2009 Journal International journal of laboratory hematology Section Abstract Doc Link 18177436 Disease Relevance 0.79 Pain Relevance 0.17
[Forensic-biochemical indices of serum amilase and cholinesterase activity in lethal poisoning with heroin].
Positive_regulation (indices) of serum amilase associated with poisoning
9) Confidence 0.02 Published 2006 Journal Sud. Med. Ekspert. Section Title Doc Link 17191723 Disease Relevance 0.19 Pain Relevance 0.08
Serum creatine phosphokinase levels were significantly elevated (mean 55.2 units) when compared to controls and nine patients with Reye syndrome.
Positive_regulation (elevated) of Serum creatine phosphokinase associated with disorders of creatine metabolism and reye's syndrome
10) Confidence 0.01 Published 1980 Journal J. Pediatr. Section Abstract Doc Link 7359257 Disease Relevance 1.21 Pain Relevance 0.12
The incidence of SVOD was 14% of the 43 patients, and 7.9% of those received autologous bone marrow transplantation (ABMT), SVOD occurred within 3 weeks after HSCT in all the 6 cases and was manifested by painful hepatomegaly, jaundice, hyperbilirubinemia, increase of serum liver enzyme level and ascites.
Positive_regulation (increase) of serum liver enzyme in liver associated with pain, pressure and volume under development, hyperbilirubinemia, hepatomegaly, jaundice and disease
11) Confidence 0.01 Published 1995 Journal Zhonghua Nei Ke Za Zhi Section Abstract Doc Link 8582182 Disease Relevance 0.92 Pain Relevance 0.10
Although the levels of serum IgG, IgA were markedly increased, there was no monoclonal component on immunoelectrophoresis.
Positive_regulation (increased) of serum IgG
12) Confidence 0.01 Published 1989 Journal Nippon Ronen Igakkai Zasshi Section Abstract Doc Link 2795981 Disease Relevance 0.71 Pain Relevance 0.18
[A case of temporal arteritis associated with marked elevation of serum IgG, IgA levels].
Positive_regulation (elevation) of serum IgG associated with giant cell arteritis
13) Confidence 0.01 Published 1989 Journal Nippon Ronen Igakkai Zasshi Section Title Doc Link 2795981 Disease Relevance 0.73 Pain Relevance 0.25
These side effects include angina crisis; elevation of serum aminotransferase,
Positive_regulation (elevation) of serum aminotransferase associated with angina
14) Confidence 0.01 Published 2008 Journal PPAR Research Section Body Doc Link PMC2464819 Disease Relevance 0.56 Pain Relevance 0.10
However, preliminary study of two germ-free animal models reported here showed the net effect of minimizing or eliminating a contribution from colonic bacteria was, in fact, an increase in serum SA levels.
Positive_regulation (increase) of serum SA
15) Confidence 0.01 Published 2008 Journal Journal of Agricultural and Food Chemistry Section Body Doc Link PMC2800778 Disease Relevance 0 Pain Relevance 0.14
Common side effects include gastrointestinal symptoms, fatigue, headache, rash, lipid abnormalities, and serum transminase elevation.
Positive_regulation (elevation) of serum transminase associated with exanthema, congenital anomalies, fatigue and headache
16) Confidence 0.01 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2701488 Disease Relevance 1.09 Pain Relevance 0.14
levels were found to be increased in conditioned serum, the effect of TNF-?
Positive_regulation (increased) of conditioned serum
17) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2911907 Disease Relevance 0.69 Pain Relevance 0.48
Among the serum hormone levels, significant increases of luteinizing hormone were observed.
Positive_regulation (increases) of serum hormone
18) Confidence 0.01 Published 1993 Journal Hinyokika Kiyo Section Abstract Doc Link 8503338 Disease Relevance 0.56 Pain Relevance 0.09
In non-pretreated hamsters, single doses of acetaminophen (200-400 mg/kg i.p.) caused elevations in serum alanine aminotransferase and sorbitol dehydrogenase activities in a dose-related manner. 3-Methylcholanthrene significantly potentiated, while phenobarbital significantly reduced acetaminophen-induced elevations in serum liver enzyme activities.
Positive_regulation (elevations) of serum liver enzyme in liver associated with paracetamol
19) Confidence 0.01 Published 1987 Journal Toxicology Section Abstract Doc Link 3564056 Disease Relevance 0.22 Pain Relevance 0.59
Serum creatinine (Scr) was elevated to 2.70 mg/dl, and urinary output was reduced to below 200 ml/day.
Positive_regulation (elevated) of Serum creatinine
20) Confidence 0.00 Published 2006 Journal Intern. Med. Section Abstract Doc Link 16880706 Disease Relevance 0.60 Pain Relevance 0.09

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