INT152292

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Context Info
Confidence 0.61
First Reported 2008
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.46
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Mmp2) cytoplasm (Mmp2) extracellular space (Mmp2)
peptidase activity (Mmp2) extracellular region (Mmp2) proteinaceous extracellular matrix (Mmp2)
Anatomy Link Frequency
endothelial cells 2
lungs 2
hippocampus 2
Mmp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 18 100.00 Very High Very High Very High
fluoxetine 2 100.00 Very High Very High Very High
Desipramine 2 100.00 Very High Very High Very High
Hippocampus 15 98.80 Very High Very High Very High
metalloproteinase 48 91.64 High High
Kinase C 10 78.32 Quite High
Calcium channel 2 66.64 Quite High
Bioavailability 5 54.60 Quite High
ischemia 6 25.60 Quite Low
Inflammation 7 21.96 Low Low
Disease Link Frequency Relevance Heat
Convulsion 3 100.00 Very High Very High Very High
Diabetes Mellitus 29 99.34 Very High Very High Very High
Bronchopulmonary Dysplasia 122 99.00 Very High Very High Very High
Uterine Fibroids 1 98.36 Very High Very High Very High
Congenital Anomalies 12 98.22 Very High Very High Very High
Stress 17 93.76 High High
Glioma 24 91.52 High High
Apoptosis 13 91.12 High High
Hepatopulmonary Syndrome 1 84.52 Quite High
Cardiovascular Disorder Under Development 1 80.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acute and chronic pharmacological antidepressants on the other hand differentially alter the expression of the TIMPs without any observed effect on hippocampal MMP-2/9 expression or activity.
Neg (without) Regulation (effect) of Gene_expression (expression) of MMP-2 associated with antidepressant
1) Confidence 0.61 Published 2008 Journal Synapse Section Abstract Doc Link 18509851 Disease Relevance 0.12 Pain Relevance 0.73
The influence of distinct classes of antidepressants, namely, electroconvulsive seizure, fluoxetine, tranylcypromine, and desipramine, on the gene expression of MMP-2, MMP-9, and TIMPs 1-4 in the hippocampus was determined using radioactive in situ hybridization.
Spec (determined) Regulation (influence) of Gene_expression (expression) of MMP-2 in hippocampus associated with desipramine, antidepressant, convulsion, hippocampus and fluoxetine
2) Confidence 0.45 Published 2008 Journal Synapse Section Abstract Doc Link 18509851 Disease Relevance 0.18 Pain Relevance 0.77
Polyunsaturated fatty acids have also been reported to influence MMP2 expression in endothelial cells [23].
Regulation (influence) of Gene_expression (expression) of MMP2 in endothelial cells
3) Confidence 0.36 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.92 Pain Relevance 0.10
The pattern of change in the activated MMP2 fraction differed significantly according to BPD status, with lower levels at birth in BDP infants, followed by a steep increase during the first days of life (p?
Regulation (differed) of Gene_expression (fraction) of MMP2 associated with bronchopulmonary dysplasia
4) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0.62 Pain Relevance 0
The pattern of change in the activated MMP2 fraction differed significantly according to BPD status, with lower levels at birth in BDP infants, followed by a steep increase during the first days of life (p?
Regulation (change) of Gene_expression (fraction) of MMP2 associated with bronchopulmonary dysplasia
5) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0.63 Pain Relevance 0
There are multiple factors implicated in vascular abnormalities under diabetic conditions.31 The matrix in the diabetic vascular wall is altered due to changes in MMP2 and MMP9 expression resulting in an increase in accumulated fibroid substances, which may participate in adversely affecting vascular activity.12,16 The intercellular gap junction connexin proteins are important for maintaining normal vascular tone through passing small molecules between cells, among which Cx40 (connexin 40) is active in the vascular wall and its downregulation results in a compromised pulmonary vascular dilatation.12 Drug intervention normalizes the abnormal Cx43, leading to a recovery of the cardiovascular abnormalities.22 An activated PKC?
Regulation (changes) of Gene_expression (expression) of MMP2 associated with kinase c, uterine fibroids, diabetes mellitus, congenital anomalies, hepatopulmonary syndrome and cardiovascular disorder under development
6) Confidence 0.26 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941789 Disease Relevance 0.77 Pain Relevance 0.13
In contrast, previous data from our laboratory demonstrated the up regulation of MMP-9 and/or MMP-2 levels in the brain [15] and lungs [42] as early as 2.5 h post-resuscitation, with a good correlation between MMP levels and in situ zymography activity in the lungs.
Regulation (regulation) of Gene_expression (levels) of MMP-2 in lungs
7) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000320 Disease Relevance 0.22 Pain Relevance 0.03

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