INT152293

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 9
Total Number 13
Disease Relevance 6.57
Pain Relevance 6.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp9) extracellular space (Mmp9) aging (Mmp9)
extracellular region (Mmp9) proteinaceous extracellular matrix (Mmp9) extracellular matrix organization (Mmp9)
Anatomy Link Frequency
lungs 2
hippocampus 2
cartilage 1
microglia 1
Mmp9 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 641 100.00 Very High Very High Very High
antidepressant 18 99.76 Very High Very High Very High
Inflammation 111 99.68 Very High Very High Very High
fibrosis 160 97.24 Very High Very High Very High
Hippocampus 53 96.84 Very High Very High Very High
cytokine 29 94.76 High High
Deafferentation 2 92.76 High High
Pain 35 92.68 High High
long-term potentiation 6 89.92 High High
ischemia 24 81.64 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 133 99.68 Very High Very High Very High
Death 45 98.28 Very High Very High Very High
Pulmonary Fibrosis 112 97.64 Very High Very High Very High
Epilepsy 3 97.24 Very High Very High Very High
Increased Venous Pressure Under Development 1 96.56 Very High Very High Very High
Diabetes Mellitus 25 95.48 Very High Very High Very High
Hypoxia 117 95.12 Very High Very High Very High
Pain 34 92.68 High High
Neurodegenerative Disease 11 91.20 High High
Disease 13 90.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antidepressant treatments regulate matrix metalloproteinases-2 and -9 (MMP-2/MMP-9) and tissue inhibitors of the metalloproteinases (TIMPS 1-4) in the adult rat hippocampus.
Regulation (regulate) of matrix metalloproteinases-2 and -9 in hippocampus associated with antidepressant, metalloproteinase and hippocampus
1) Confidence 0.49 Published 2008 Journal Synapse Section Title Doc Link 18509851 Disease Relevance 0.16 Pain Relevance 0.64
From the 7th day, there were fewer inflammatory cells, and the intensity of the MMP-2 and MMP-9 staining was weakened.
Regulation (intensity) of MMP-9 associated with inflammation and metalloproteinase
2) Confidence 0.37 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.51 Pain Relevance 0.66
In our study, the levels of the MMP-2 and MMP-9 in the lung parenchyma corresponded well to those of BAL fluid.
Regulation (corresponded) of MMP-9 in lung associated with metalloproteinase
3) Confidence 0.37 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.58 Pain Relevance 1.08
Our laboratory has focused on hippocampal mediated spatial memory and measured elevations in hippocampal MMP-3 and MMP-9 during acquisition of the Morris water
Regulation (focused) of MMP-9 associated with metalloproteinase
4) Confidence 0.32 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1838960 Disease Relevance 0.25 Pain Relevance 0.65
The reduction in chondropathy scores is likely due to a direct effect of the MMPi on proteinases, such as collagenase 3 or MMP9, that can degrade cartilage matrix proteins.
Spec (likely) Regulation (effect) of MMP9 in cartilage
5) Confidence 0.28 Published 2010 Journal Osteoarthritis and Cartilage Section Body Doc Link PMC2853084 Disease Relevance 0.73 Pain Relevance 0.63
Top regulated genes included MMP9 (-3.36 fold), SERPINB6 (-4.16 fold), IL1R2 (2.14 fold), TLR2 (-1.69 fold), ICAM2 (-1.33), and ANXA2 (-1.21 fold).


Regulation (regulated) of MMP9
6) Confidence 0.23 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2875237 Disease Relevance 0.45 Pain Relevance 0
In this study, we tried to investigate the changes in the level of MMP-2 and MMP-9 and their various cellular sources in different stages of pulmonary fibrosis by estimating the changes of the activity of those MMPs at different time intervals in bleomycin-induced pulmonary fibrosis in rats.


Spec (investigate) Regulation (changes) of MMP-9 associated with fibrosis, metalloproteinase and pulmonary fibrosis
7) Confidence 0.22 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.80 Pain Relevance 0.65
Antidepressant treatments regulate matrix metalloproteinases-2 and -9 (MMP-2/MMP-9) and tissue inhibitors of the metalloproteinases (TIMPS 1-4) in the adult rat hippocampus.
Regulation (regulate) of MMP-9 in hippocampus associated with antidepressant, metalloproteinase and hippocampus
8) Confidence 0.22 Published 2008 Journal Synapse Section Title Doc Link 18509851 Disease Relevance 0.16 Pain Relevance 0.64
The change of MMP-9 was more profound, reaching 6 times the level on the 4th day compared to that of the 1st day, and then rapidly decreased and remained unchanged at 2 times the level from the 5th to 14th day.
Regulation (change) of MMP-9 associated with metalloproteinase
9) Confidence 0.20 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.12 Pain Relevance 0.62
In contrast, previous data from our laboratory demonstrated the up regulation of MMP-9 and/or MMP-2 levels in the brain [15] and lungs [42] as early as 2.5 h post-resuscitation, with a good correlation between MMP levels and in situ zymography activity in the lungs.
Regulation (regulation) of MMP-9 in lungs
10) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000320 Disease Relevance 0.22 Pain Relevance 0.03
In this context, early cytotoxic up regulation of MMP-9 levels have been associated with neuronal death in the ischemic and epileptic rodent brain [12], [13], and early MMP-9 up regulation in reactive microglia after ischemic episodes has been suggested to underlie the neurotoxic/inflammatory effect of the enzyme assessed in adult [37] and neonatal rat models [10].
Regulation (regulation) of MMP-9 in microglia associated with epilepsy, inflammation and death
11) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000320 Disease Relevance 0.73 Pain Relevance 0.15
0.002 and p<0.001 for the 21%, 40% and 100% groups), suggesting an up regulation of the MMP activity, particularly the gelatinases MMP-2 and/or MMP-9.
Regulation (regulation) of MMP-9
12) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000320 Disease Relevance 0.61 Pain Relevance 0.09
We found, however, no associations between abnormal glucose regulation and the levels of IL-18, MMP-9, TIMP-1, and adiponectin.
Regulation (regulation) of MMP-9
13) Confidence 0.08 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940874 Disease Relevance 1.27 Pain Relevance 0.17

General Comments

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