INT152308

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.40
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 6.39
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

proteinaceous extracellular matrix (Lgals3) nucleus (Lgals3) extracellular matrix organization (Lgals3)
cytoplasm (Lgals3)
Anatomy Link Frequency
microglia 3
macrophage 1
plasma 1
heart 1
Lgals3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 73 99.26 Very High Very High Very High
Neuropathic pain 2 99.00 Very High Very High Very High
fibrosis 170 92.96 High High
Spinal cord 15 92.92 High High
Demyelination 3 92.00 High High
Sciatic nerve 7 85.32 High High
Gabapentin 2 82.84 Quite High
Chronic pancreatitis 7 79.48 Quite High
nMDA receptor antagonist 1 76.48 Quite High
antagonist 1 75.00 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 80 99.26 Very High Very High Very High
Fibrosis 148 99.12 Very High Very High Very High
Neuropathic Pain 2 99.00 Very High Very High Very High
Apoptosis 15 98.38 Very High Very High Very High
Myocardial Infarction 231 98.26 Very High Very High Very High
Brain Injury 141 97.16 Very High Very High Very High
Aging 64 96.76 Very High Very High Very High
Injury 143 94.76 High High
Cancer 39 92.40 High High
Demyelinating Disease 3 92.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Most galectins are bivalent or multivalent with regard to their carbohydrate-binding features: one-CRD galectins may form dimers; two-CRD galectins have two carbohydrate-binding sites; whereas galectin-3 forms pentamers upon binding to multivalent carbohydrates.
galectin-3 Binding (binding) of
1) Confidence 0.40 Published 2010 Journal Curr Heart Fail Rep Section Body Doc Link PMC2831188 Disease Relevance 0.11 Pain Relevance 0
Galectin-3 binding sites were visualized by biotinylated antibodies and localized predominantly to fibrotic areas [20], in line with the evidence that galectin-3 binds extracellular proteins.
galectin-3 Binding (binds) of associated with fibrosis
2) Confidence 0.40 Published 2010 Journal Curr Heart Fail Rep Section Body Doc Link PMC2831188 Disease Relevance 1.08 Pain Relevance 0.33
These results indicate the synergistic interaction between DHQ and 3M-GBP in this animal model of neuropathic pain.
GBP Binding (interaction) of associated with neuropathic pain
3) Confidence 0.36 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18511033 Disease Relevance 0.17 Pain Relevance 0.45
RII/CD23) and Mac-2/ ?
Mac-2 Binding (/) of
4) Confidence 0.36 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685643 Disease Relevance 0.40 Pain Relevance 0
In vitro studies further support a role for galectin-3/Mac-2 expressing microglia in myelin phagocytosis [21,23,37].
galectin-3 Binding (role) of in microglia
5) Confidence 0.33 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0.75 Pain Relevance 0.15
In our studies, galectin-3/Mac-2-ir microglia are robustly upregulated within the corpus callosum following diffuse TBI, and we find ultrastructural evidence one day following injury that these microglia engulf damaged axons.
galectin-3/Mac-2-ir Binding (microglia) of in microglia associated with injury and brain injury
6) Confidence 0.33 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0.83 Pain Relevance 0.15
In vitro studies further support a role for galectin-3/Mac-2 expressing microglia in myelin phagocytosis [21,23,37].
Mac-2 Binding (role) of in microglia
7) Confidence 0.33 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0.75 Pain Relevance 0.15
This means that galectin-3 consists of carbohydrate recognition and collagen-like domains, which makes it able to interact with a wide array of extracellular matrix proteins, carbohydrates (eg, N-acetyllactosamine), and unglycosylated molecules, such as cell surface receptors (macrophage CD11b/CD18) and extracellular receptors (collagen IV).
galectin-3 Binding (recognition) of in macrophage
8) Confidence 0.31 Published 2010 Journal Curr Heart Fail Rep Section Body Doc Link PMC2831188 Disease Relevance 0.05 Pain Relevance 0
Galectin-3 interacts with AGE-R components, thus contributing to the elimination of these pathogenic substances.
Galectin-3 Binding (interacts) of
9) Confidence 0.31 Published 2010 Journal Curr Heart Fail Rep Section Body Doc Link PMC2831188 Disease Relevance 0.64 Pain Relevance 0.11
Galectin-3 contains several phosphorylation sites and other determinants important for the secretion of galectin-3, which proceeds via a novel, nonclassical pathway [15].Through its interaction with extracellular matrix proteins, galectin-3 can cross the plasma membrane despite its lack of appropriate signal peptides.
galectin-3 Binding (interaction) of in plasma
10) Confidence 0.31 Published 2010 Journal Curr Heart Fail Rep Section Body Doc Link PMC2831188 Disease Relevance 0.17 Pain Relevance 0
If it is indeed proven that standard treatment of heart failure is associated with lowering of galectin-3 expression and levels, one could argue that galectin-3 itself could also be a target for therapy.
galectin-3 Binding (target) of in heart associated with myocardial infarction
11) Confidence 0.31 Published 2010 Journal Curr Heart Fail Rep Section Body Doc Link PMC2831188 Disease Relevance 0.65 Pain Relevance 0.05
Galectin-3 mainly binds to glycosylated proteins of the matrix, including laminin, fibronectin, and tenascin [11, 12].
Galectin-3 Binding (binds) of
12) Confidence 0.30 Published 2010 Journal Curr Heart Fail Rep Section Body Doc Link PMC2831188 Disease Relevance 0.15 Pain Relevance 0
B pathway, such as STAT1 and TLR1; cell proliferation/apoptosis, such as IER3; EHF; LRPAP1 and inflammation such as CCL7; CXCL16; B2M; IL7R and LGALS3 were among the genes whose transcripts were increased in the context of both in vivo aging and in vitro senescence.
LGALS3 Binding (were) of associated with aging, inflammation and apoptosis
13) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931699 Disease Relevance 0.64 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox