INT152312

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 1.46
Pain Relevance 4.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Ednrb) signal transduction (Ednrb) plasma membrane (Ednrb)
signal transducer activity (Ednrb)
Ednrb (Mus musculus)
Pain Link Frequency Relevance Heat
Neurotransmitter 32 100.00 Very High Very High Very High
Action potential 24 100.00 Very High Very High Very High
Clonidine 21 99.92 Very High Very High Very High
Calcium channel 1 99.08 Very High Very High Very High
Glutamate 52 98.96 Very High Very High Very High
antagonist 31 96.80 Very High Very High Very High
sodium channel 5 96.20 Very High Very High Very High
tetrodotoxin 6 95.28 Very High Very High Very High
agonist 54 92.64 High High
conotoxin 1 90.44 High High
Disease Link Frequency Relevance Heat
Nociception 3 95.76 Very High Very High Very High
Targeted Disruption 4 93.36 High High
Status Epilepticus 74 93.24 High High
Pain 4 86.56 High High
INFLAMMATION 2 81.76 Quite High
Hypersensitivity 1 79.84 Quite High
Epilepsy 102 76.64 Quite High
Convulsion 68 75.00 Quite High
Sclerosis 8 5.00 Very Low Very Low Very Low
Gliosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, IL-18, IFN-gamma, endothelin acting on endothelin ETA and ETB receptors, and prostanoids mediate PBQ-induced writhing response in mice.
Positive_regulation (acting) of ETB
1) Confidence 0.49 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18511039 Disease Relevance 0.22 Pain Relevance 0.35
Here we found that the inhibitory effect of clonidine on sIPSCs was enhanced during postnatal development.
Positive_regulation (enhanced) of sIPSCs associated with clonidine
2) Confidence 0.04 Published 2008 Journal Neuroscience Section Abstract Doc Link 18691636 Disease Relevance 0 Pain Relevance 0.59
In parallel with this rise in the rate of firing, the magnitude of the clonidine-mediated inhibition of sIPSCs increased during postnatal development.
Positive_regulation (increased) of sIPSCs associated with clonidine
3) Confidence 0.04 Published 2008 Journal Neuroscience Section Abstract Doc Link 18691636 Disease Relevance 0 Pain Relevance 0.77
Therefore, the developmental enhancement of the clonidine-mediated inhibition of sIPSCs is attributed to an age-dependent increase in AP-derived sIPSCs, which can be blocked by clonidine.
Positive_regulation (increase) of sIPSCs associated with action potential and clonidine
4) Confidence 0.04 Published 2008 Journal Neuroscience Section Abstract Doc Link 18691636 Disease Relevance 0 Pain Relevance 0.63
This inhibition is permanent, reversible and does not result in functional upregulation of TTX-sensitive (TTX-S) VGSCs, voltage-gated calcium channels (VGCCs) or transient receptor potential (TRP) channels present in nociceptive neurones.
Positive_regulation (upregulation) of TTX-S associated with nociception and calcium channel
5) Confidence 0.04 Published 2010 Journal J. Physiol. (Lond.) Section Abstract Doc Link 20308253 Disease Relevance 0.69 Pain Relevance 0.82
Within the limits of our recording system (i.e. 13.5 Hz confocal microscopy acquisition rate) the present study demonstrates that focal increases in intracellular Ca2+ are tightly temporally coupled to the electrical sign of spontaneous neurotransmitter release in this tissue; i.e. the sEJP.
Positive_regulation (increases) of sEJP associated with neurotransmitter
6) Confidence 0.01 Published 2007 Journal Neuroscience Section Body Doc Link PMC2543106 Disease Relevance 0 Pain Relevance 0.17
We found no significant effects of CB1R activation on overall sEPSCs or mEPSCs in control mice, but effects of CB1R activation specifically on mossy cell inputs were not tested.
Positive_regulation (activation) of sEPSCs
7) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871782 Disease Relevance 0.29 Pain Relevance 0.41
Effect of CB1R activation on sEPSCs
Positive_regulation (activation) of sEPSCs
8) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871782 Disease Relevance 0.26 Pain Relevance 0.29

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