INT152326

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.44
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (CAV2) mitochondrion organization (CAV2) intracellular (CAV2)
protein complex (CAV2) cytoplasm (CAV2) cytosol (CAV2)
CAV2 (Homo sapiens)
Pain Link Frequency Relevance Heat
nav1.3 1 99.96 Very High Very High Very High
nav1.8 1 99.80 Very High Very High Very High
Neuropathic pain 4 99.68 Very High Very High Very High
Nav1.7 1 99.64 Very High Very High Very High
hyperexcitability 1 97.12 Very High Very High Very High
addiction 1 73.00 Quite High
Glutamate receptor 2 68.16 Quite High
monoamine 1 51.04 Quite High
Calcium channel 15 50.00 Quite Low
neuralgia 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 4 99.68 Very High Very High Very High
Disease 1 92.60 High High
Neurological Disease 2 86.20 High High
Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The impact of single amino acid substitutions on G protein inhibition is reminiscent of our earlier findings showing that phosphorylation of a single I-II linker residue, Thr422, can disrupt modulation of Cav2.2 channels by G?
Regulation (modulation) of Gene_expression (channels) of Cav2
1) Confidence 0.36 Published 2010 Journal Mol Brain Section Body Doc Link PMC2829547 Disease Relevance 0 Pain Relevance 0.04
Among the molecular drivers are ion channels (Nav1.7, Nav1.8, Nav1.3, Cav2.2, and alpha2-delta subunits) whose expression is changed during neuropathic pain and their block shows therapeutic utility.
Regulation (changed) of Gene_expression (expression) of Cav2 associated with nav1.3, neuropathic pain, nav1.8 and nav1.7
2) Confidence 0.10 Published 2008 Journal Br J Anaesth Section Abstract Doc Link 18511441 Disease Relevance 0.44 Pain Relevance 0.70

General Comments

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