INT152347

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 6.13
Pain Relevance 7.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GCH1) small molecule metabolic process (GCH1) nucleolus (GCH1)
nucleus (GCH1) protein complex assembly (GCH1) protein complex (GCH1)
GCH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
GCH1 210 100.00 Very High Very High Very High
Pain 437 99.74 Very High Very High Very High
Stimulus evoked pain 1 99.44 Very High Very High Very High
Analgesic 24 97.80 Very High Very High Very High
Fibrositis 22 95.80 Very High Very High Very High
tolerance 13 88.12 High High
Pain threshold 12 87.36 High High
Serotonin 3 86.36 High High
opioid receptor 5 82.52 Quite High
Tetrahydrobiopterin 33 82.04 Quite High
Disease Link Frequency Relevance Heat
Pain 436 99.74 Very High Very High Very High
Hypersensitivity 1 99.24 Very High Very High Very High
Disease 7 99.04 Very High Very High Very High
Fibromyalgia 22 95.80 Very High Very High Very High
Fetal Death 1 92.04 High High
Phenylketonuria 2 89.68 High High
Dystonia 2 88.52 High High
Inborn Genetic Diseases 1 87.20 High High
Heart Rate Under Development 1 81.52 Quite High
Neuropathic Pain 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Considering the non-significant association between GCH1 genetic variations and similar thermal pain sensitivity in our sample, the inconsistency cannot be easily explained by the differences in stimulus modalities.
GCH1 Binding (association) of associated with pain and gch1
1) Confidence 0.37 Published 2007 Journal Mol Pain Section Body Doc Link PMC1821314 Disease Relevance 0.70 Pain Relevance 1.02
Genotyping of the pain-protective SNP combination of GCH1
GCH1 Binding (combination) of associated with pain and gch1
2) Confidence 0.37 Published 2010 Journal Mol Pain Section Body Doc Link PMC2912270 Disease Relevance 0.82 Pain Relevance 1.01
However, we could not find any significant genetic associations between variations of GCH1 including SNPs and haplotypes and pain sensitivity or analgesic responses in this cohort of European American females and males even without multiple testing corrections.
GCH1 Neg (not) Binding (associations) of associated with pain, analgesic and gch1
3) Confidence 0.36 Published 2007 Journal Mol Pain Section Body Doc Link PMC1821314 Disease Relevance 0.34 Pain Relevance 0.79
Considering population stratification, previously reported associations between GCH1 genetic variations and pain sensitivity appear weak or negligible in this well characterized model of pain.


GCH1 Binding (associations) of associated with pain and gch1
4) Confidence 0.36 Published 2007 Journal Mol Pain Section Body Doc Link PMC1821314 Disease Relevance 0.52 Pain Relevance 0.55
Given these questions of study design related to population stratification, haploblock size, and disparate pain measures in Tegeder et al with similar statistical power of our samples, it is more probable that this association between GCH1 genetic variations and pain sensitivity are, if any, weak or negligible regardless of their strong in vitro and animal findings.
GCH1 Spec (probable) Binding (association) of associated with pain and gch1
5) Confidence 0.36 Published 2007 Journal Mol Pain Section Body Doc Link PMC1821314 Disease Relevance 0.55 Pain Relevance 0.54
Considering population stratification, previously reported associations between GCH1 genetic variations and pain sensitivity appear weak or negligible in this well characterized model of pain.



GCH1 Binding (associations) of associated with pain and gch1
6) Confidence 0.36 Published 2007 Journal Mol Pain Section Abstract Doc Link PMC1821314 Disease Relevance 0.66 Pain Relevance 0.87
Figure 5 shows an example of non-significant association between GCH1 genetic variations and pain sensitivity in European American females (GCH1 tag SNP combinations and heat and cold pain ratings).


GCH1 Binding (association) of associated with pain and gch1
7) Confidence 0.36 Published 2007 Journal Mol Pain Section Body Doc Link PMC1821314 Disease Relevance 0.37 Pain Relevance 0.79
That is, a non-coding GCH1 haplotype has been associated with reduced pain hypersensitivity and with altered vascular endothelial function.
GCH1 Binding (associated) of associated with hypersensitivity, stimulus evoked pain and gch1
8) Confidence 0.36 Published 2008 Journal Mutat. Res. Section Abstract Doc Link 18515178 Disease Relevance 0.92 Pain Relevance 0.66
Three SNPs forming a proposed "pain-protective" haplotype in GCH1 (rs10483639, rs3783641 and rs8007267) and two SNPs in OPRM1 (rs1777971 (A118G) and rs563649) were genotyped in cases with persistent CWP (CWP present at ?
GCH1 Binding (haplotype) of associated with pain, gch1 and fibrositis
9) Confidence 0.33 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2759922 Disease Relevance 1.26 Pain Relevance 1.13

General Comments

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