INT15237

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Context Info
Confidence 0.96
First Reported 1982
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 31
Total Number 35
Disease Relevance 10.26
Pain Relevance 16.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mme) plasma membrane (Mme)
Anatomy Link Frequency
brain 2
myocytes 2
caudate putamen 1
dorsal horn 1
neural 1
Mme (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 47 100.00 Very High Very High Very High
opiate 15 100.00 Very High Very High Very High
Cholecystokinin 2 100.00 Very High Very High Very High
Neuropeptide 15 99.96 Very High Very High Very High
substance P 42 99.92 Very High Very High Very High
bradykinin 28 99.88 Very High Very High Very High
Endogenous opioid 8 99.84 Very High Very High Very High
Opioid 25 99.76 Very High Very High Very High
Pain 7 99.48 Very High Very High Very High
drug abuse 3 99.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Natriuresis 28 99.82 Very High Very High Very High
Pain 6 99.48 Very High Very High Very High
Drug Dependence 3 99.20 Very High Very High Very High
Pancreatitis 8 99.16 Very High Very High Very High
Myocardial Infarction 10 98.92 Very High Very High Very High
Neurogenic Inflammation 7 98.80 Very High Very High Very High
Urological Neuroanatomy 11 98.74 Very High Very High Very High
Abdominal Cramps 3 98.40 Very High Very High Very High
Impaired Glucose Tolerance 100 98.32 Very High Very High Very High
Obesity 190 97.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subsequently, pulmonary vascular function, as well as substance P (a tachykinin) level and neutral endopeptidase (NEP, the major degradation enzyme for tachykinins) activity in the lungs were measured.
Protein_catabolism (degradation) of NEP in lungs associated with substance p
1) Confidence 0.96 Published 1995 Journal Respir Physiol Section Abstract Doc Link 7539934 Disease Relevance 0.93 Pain Relevance 0.86
We also sought to determine whether the fate of the neutrophils is influenced by neutral endopeptidase (NEP), an enzyme that degrades the tachykinins that produce neurogenic inflammation.
Protein_catabolism (degrades) of NEP in neutrophils associated with inflammation and neurogenic inflammation
2) Confidence 0.89 Published 1990 Journal J. Appl. Physiol. Section Abstract Doc Link 1963889 Disease Relevance 0.35 Pain Relevance 0.26
The neuropeptides are degraded by peptidases, e.g., neutral endopeptidase (NEP) that is present in the nasal mucosa.
Protein_catabolism (degraded) of NEP in nasal mucosa associated with neuropeptide
3) Confidence 0.88 Published 1998 Journal Am J Rhinol Section Abstract Doc Link 9578933 Disease Relevance 0 Pain Relevance 0.62
Enkephalin degradation includes an enkephalinase (EC 3.4.24. 11) and the effects on the colic electromyographic profile of its inhibition by acetorphan has been investigated in the unrestrained rat.
Protein_catabolism (degradation) of enkephalinase associated with colic and enkephalin
4) Confidence 0.86 Published 1993 Journal Neuropeptides Section Abstract Doc Link 8392143 Disease Relevance 0.10 Pain Relevance 0.24
Thiorphan and its prodrug, acetorphan, are two inhibitors of enkephalinase (EC 3.4.24.11), a membrane-bound peptidase which plays an important role in the metabolic degradation of enkephalins.
Protein_catabolism (degradation) of enkephalinase associated with enkephalin
5) Confidence 0.82 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3234479 Disease Relevance 0.08 Pain Relevance 0.27
Substance P is degraded by the peptidases neutral endopeptidase-24.11 (NEP-24.11) and angiotensin converting enzyme (ACE).
Protein_catabolism (degraded) of peptidases neutral endopeptidase-24 associated with substance p
6) Confidence 0.81 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8423549 Disease Relevance 0.19 Pain Relevance 0.44
OBJECTIVE: Increased secretion of atrial and brain natriuretic peptide (ANP and BNP) from hearts is known to exhibit favorable effects in patients and animals with heart failure, and inhibition of neutral endopeptidase (NEP), an enzyme that degrades ANP and BNP, may further increase these peptide levels.
Protein_catabolism (degrades) of NEP in hearts associated with natriuresis and myocardial infarction
7) Confidence 0.79 Published 2001 Journal Cardiovasc. Res. Section Abstract Doc Link 11476752 Disease Relevance 0.52 Pain Relevance 0
Neutral endopeptidase 24.11 (NEP) and angiotensin-converting enzyme (ACE) degrade neuropeptides, including enkephalin and are expressed in the brain.
Protein_catabolism (degrade) of Neutral endopeptidase 24.11 in brain associated with neuropeptide and enkephalin
8) Confidence 0.77 Published 1998 Journal Biochim. Biophys. Acta Section Abstract Doc Link 9630637 Disease Relevance 0.07 Pain Relevance 0.79
Intracerebroventricular administration of phelorphan (158 nmol/2 microliters), a blocker of dipeptidylaminopeptidase (enkephalinase B) and other enzymes involved in the enkephalin biodegradation, inhibited in chronic morphine-dependent rats, the occurrence of some of the naloxone-precipitated withdrawal symptoms.
Protein_catabolism (biodegradation) of enkephalinase associated with narcan, enkephalin, withdrawal, intracerebroventricular and morphine
9) Confidence 0.75 Published 1987 Journal Neuroscience Section Abstract Doc Link 2888045 Disease Relevance 0.31 Pain Relevance 0.61
This study was performed to determine 1) if the effect of opioid antagonists on the dopamine response to amphetamine is mediated in either the terminal or cell body region of the nigrostriatal and mesolimbic pathways, and 2) if the enkephalinase inhibitor thiorphan, which slows degradation of endogenous opioid peptides, increases the dopamine response to amphetamine but not to cocaine.
Protein_catabolism (degradation) of enkephalinase in body region associated with dopamine, antagonist, endogenous opioid, opioid and cocaine
10) Confidence 0.66 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11861800 Disease Relevance 0 Pain Relevance 1.04
Fluorogenic substrates for the enkephalin-degrading neutral endopeptidase (Enkephalinase).
Protein_catabolism (degrading) of Enkephalinase associated with enkephalin
11) Confidence 0.65 Published 1984 Journal Arch. Biochem. Biophys. Section Title Doc Link 6375573 Disease Relevance 0 Pain Relevance 0.34
We found immunohistochemical evidence of the peptide-degrading enzyme neutral endopeptidase (NEP) in cultured rat myocytes.
Protein_catabolism (degrading) of NEP in myocytes
12) Confidence 0.65 Published 1994 Journal Circ. Res. Section Abstract Doc Link 7923622 Disease Relevance 0 Pain Relevance 0.27
We found immunohistochemical evidence of the peptide-degrading enzyme neutral endopeptidase (NEP) in cultured rat myocytes.
Protein_catabolism (degrading) of enzyme neutral endopeptidase in myocytes
13) Confidence 0.65 Published 1994 Journal Circ. Res. Section Abstract Doc Link 7923622 Disease Relevance 0 Pain Relevance 0.27
In vitro, the Ki for SCH 32615 to block the degradation of Met5-enkephalin by isolated enkephalinase is 19.5 +/- 0.9 nM.
Protein_catabolism (degradation) of enkephalinase associated with enkephalin
14) Confidence 0.64 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3164388 Disease Relevance 0 Pain Relevance 0.43
The present study produced conditioned reinforcement with local injections of exogenous d-ala2-met5-enkephalinamide (DALA), a potent analogue of met-enkephalin, and with thiorphan , an enkephalinase inhibitor which protects endogenous opiates from enzymic degradation.
Protein_catabolism (degradation) of enkephalinase associated with opiate and enkephalin
15) Confidence 0.60 Published 1984 Journal Behav. Neurosci. Section Abstract Doc Link 6586195 Disease Relevance 0 Pain Relevance 0.77
Fluorogenic substrates for the enkephalin-degrading neutral endopeptidase (Enkephalinase).
Protein_catabolism (degrading) of neutral endopeptidase associated with enkephalin
16) Confidence 0.57 Published 1984 Journal Arch. Biochem. Biophys. Section Title Doc Link 6375573 Disease Relevance 0 Pain Relevance 0.33
Because neutral endopeptidase (NEP) effectively cleaves tachykinins, we incubated bronchial tissues with the NEP inhibitor phosphoramidon (10(-5) M) to maintain the activity of endogenously released tachykinins.
Protein_catabolism (cleaves) of NEP
17) Confidence 0.55 Published 1997 Journal Int. Arch. Allergy Immunol. Section Abstract Doc Link 9081566 Disease Relevance 0.09 Pain Relevance 0.05
Nevertheless, the responses to substance P and neurokinin A were clearly potentiated in rats given phosphoramidon, indicating that NEP effectively degrades tachykinins in vivo.
Protein_catabolism (degrades) of NEP associated with substance p
18) Confidence 0.50 Published 1994 Journal Agents Actions Section Abstract Doc Link 7847182 Disease Relevance 0 Pain Relevance 0.51
These data suggest that in the presence of a strong thermal stimulus, the behavioral response is subject to a tonically active or stimulus-evoked modulation by the local release in the PAG, VM and AM of an agent, presumably an enkephalin peptide, the degradation of which is altered by enkephalinase inhibition.
Protein_catabolism (degradation) of enkephalinase in PAG associated with medulla, urological neuroanatomy, enkephalin and amygdala
19) Confidence 0.45 Published 1990 Journal Brain Res. Section Abstract Doc Link 2207626 Disease Relevance 0.58 Pain Relevance 0.97
The natriuretic peptides are also degraded by neutral endopeptidase [20].
Protein_catabolism (degraded) of neutral endopeptidase associated with natriuresis
20) Confidence 0.44 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2933895 Disease Relevance 0.85 Pain Relevance 0.15

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