INT15238

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 1985
Last Reported 2011
Negated 3
Speculated 2
Reported most in Abstract
Documents 24
Total Number 27
Disease Relevance 11.86
Pain Relevance 11.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (NPY) extracellular space (NPY) extracellular region (NPY)
cell (NPY)
Anatomy Link Frequency
plasma 5
CSF 4
nerve 2
neurons 2
knee joint 1
NPY (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 137 100.00 Very High Very High Very High
substance P 96 100.00 Very High Very High Very High
Calcitonin gene-related peptide 12 100.00 Very High Very High Very High
Dopamine 3 100.00 Very High Very High Very High
Serotonin 3 100.00 Very High Very High Very High
gABA 1 100.00 Very High Very High Very High
Glutamate 1 100.00 Very High Very High Very High
Enkephalin 12 99.64 Very High Very High Very High
noradrenaline 19 99.62 Very High Very High Very High
Pain 7 99.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 3 100.00 Very High Very High Very High
Appetite Loss 16 99.32 Very High Very High Very High
Obesity 24 99.28 Very High Very High Very High
Thinness 1 99.12 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 22 99.04 Very High Very High Very High
Pain 7 99.00 Very High Very High Very High
Cancer 9 98.70 Very High Very High Very High
Hypertension 5 98.56 Very High Very High Very High
Dementia 3 98.50 Very High Very High Very High
Nervous System Injury 2 98.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased CSF NPY-LI was positively correlated with the degree of HIV encephalopathy (P < 0.01, Kruskal-Wallis test).
Positive_regulation (Increased) of NPY in CSF associated with encephalopathy and acquired immune deficiency syndrome or hiv infection
1) Confidence 0.67 Published 1996 Journal J. Neurol. Sci. Section Abstract Doc Link 8815163 Disease Relevance 1.06 Pain Relevance 0.39
In our study, NPY was not significantly increased after conjunctival allergen challenge, suggesting a different role of this neuromediator in the ocular surface immune reaction.
Neg (not) Positive_regulation (increased) of NPY
2) Confidence 0.56 Published 2011 Journal Molecular Vision Section Body Doc Link PMC3021574 Disease Relevance 1.21 Pain Relevance 0.23
In comparison with earlier findings in the knee joint significantly higher concentrations of SP-LI, CGRP-LI and NPY-LI were found in the TMJ.
Positive_regulation (concentrations) of NPY in knee joint
3) Confidence 0.49 Published 1991 Journal Int J Oral Maxillofac Surg Section Abstract Doc Link 1719105 Disease Relevance 0.40 Pain Relevance 0.60
The neurochemical signature of the centrifugal visual neurons also varies both between and within groups: thus, several neuroactive substances used by these neurons have been identified; GABA, glutamate, aspartate, acetylcholine, serotonin, dopamine, histamine, nitric oxide, GnRH, FMRF-amide-like peptides, Substance P, NPY and met-enkephalin.
Positive_regulation (varies) of NPY in neurons associated with dopamine, glutamate, gaba, enkephalin, serotonin and substance p
4) Confidence 0.49 Published 2006 Journal Brain research reviews Section Abstract Doc Link 16469387 Disease Relevance 0.19 Pain Relevance 0.46
No significant differences were observed in CSF levels of CRH, NPY and GHRH between obese and normal weight subjects, though GHRH levels were close to the assay sensitivity.
Positive_regulation (levels) of NPY in CSF associated with obesity
5) Confidence 0.49 Published 1995 Journal Int. J. Obes. Relat. Metab. Disord. Section Abstract Doc Link 7719386 Disease Relevance 0.64 Pain Relevance 0
Multiple step-wise regression analysis showed that most of the variation in NPY-LI, CGRP-LI and SP-LI in group I was explained by NKA-LI, but the regression did not reach statistical significance in group II.
Positive_regulation (variation) of NPY
6) Confidence 0.49 Published 1995 Journal Arch. Oral Biol. Section Abstract Doc Link 7540832 Disease Relevance 0.38 Pain Relevance 0.52
Elevation of plasma neuropeptide Y-like immunoreactivity and noradrenaline during myocardial ischaemia in man.
Positive_regulation (Elevation) of neuropeptide Y in plasma associated with coronary artery disease, noradrenaline and neuropeptide
7) Confidence 0.47 Published 1990 Journal J. Intern. Med. Section Title Doc Link 2280235 Disease Relevance 0.88 Pain Relevance 0.65
This release appears to be attenuated by activation of alpha-adrenoceptors since phentolamine and clonidine, respectively, enhanced and suppressed the exercise-induced increase in the plasma levels of both NPY-LI and NA.
Positive_regulation (increase) of NPY in plasma associated with clonidine
8) Confidence 0.47 Published 1988 Journal Acta Physiol Scand Suppl Section Abstract Doc Link 3232527 Disease Relevance 0.06 Pain Relevance 0.34
The plasma levels of NPY-LI were increased during control conditions, and altered by clonidine and phentolamine, mainly at high work loads, which may indicate preferential release of the peptide at high levels of sympathetic activity. 5.
Positive_regulation (increased) of NPY in plasma associated with clonidine
9) Confidence 0.47 Published 1988 Journal Acta Physiol Scand Suppl Section Abstract Doc Link 3232527 Disease Relevance 0.06 Pain Relevance 0.34
Our data suggest that increased CSF NPY-LI is a relatively specific phenomenon of HIV encephalopathy and may be involved in the pathogenesis of HIV-related neurological dysfunction.
Positive_regulation (increased) of NPY in CSF associated with anesthesia, encephalopathy and acquired immune deficiency syndrome or hiv infection
10) Confidence 0.45 Published 1996 Journal J. Neurol. Sci. Section Abstract Doc Link 8815163 Disease Relevance 1.13 Pain Relevance 0.41
Inflammatory disorders of the central nervous system and dementia due to other causes in HIV-seronegative patients were not associated with increased CSF NPY-LI.
Neg (not) Positive_regulation (increased) of NPY in central nervous system associated with dementia, inflammation, acquired immune deficiency syndrome or hiv infection and central nervous system
11) Confidence 0.45 Published 1996 Journal J. Neurol. Sci. Section Abstract Doc Link 8815163 Disease Relevance 1.13 Pain Relevance 0.40
Prior to tumor removal plasma concentration of noradrenaline (25.9 nmol/l) and NPY (14 pmol/l) were markedly elevated.
Positive_regulation (elevated) of NPY in plasma associated with cancer and noradrenaline
12) Confidence 0.45 Published 1990 Journal Monatsschr Kinderheilkd Section Abstract Doc Link 2233767 Disease Relevance 0.35 Pain Relevance 0.67
Underweight anorectic patients have been found to have elevations of cerebrospinal fluid level of neuropeptide Y, corticotropin releasing hormone and vasopressin as well as reductions of beta-endorphin and oxytocin level.
Positive_regulation (elevations) of neuropeptide Y in cerebrospinal fluid associated with appetite loss, neuropeptide and thinness
13) Confidence 0.45 Published 1994 Journal Psychiatr. Pol. Section Abstract Doc Link 7991711 Disease Relevance 0.73 Pain Relevance 0.33
In contrast, neuropeptide Y (NPY)-containing nerve fibres are increased in number in the diseased segment, probably reflecting the adrenergic hyperinnervation.
Spec (probably) Positive_regulation (increased) of NPY in nerve associated with neuropeptide
14) Confidence 0.45 Published 1994 Journal Histol. Histopathol. Section Abstract Doc Link 7981507 Disease Relevance 0.42 Pain Relevance 0.32
In contrast, neuropeptide Y (NPY)-containing nerve fibres are increased in number in the diseased segment, probably reflecting the adrenergic hyperinnervation.
Spec (probably) Positive_regulation (increased) of neuropeptide Y in nerve associated with neuropeptide
15) Confidence 0.45 Published 1994 Journal Histol. Histopathol. Section Abstract Doc Link 7981507 Disease Relevance 0.42 Pain Relevance 0.32
We have determined if tracheal intubation causes an increase in neuropeptide Y (NPY), a marker of major adrenergic activation, and investigated if rectal premedication with clonidine 2.5 micrograms kg-1 might be capable of attenuating the stress response to tracheal intubation compared with midazolam 300 micrograms kg-1, in 20 paediatric patients (1-9 yr).
Positive_regulation (increase) of neuropeptide Y associated with stress, versed, neuropeptide and clonidine
16) Confidence 0.45 Published 1999 Journal Br J Anaesth Section Abstract Doc Link 10434822 Disease Relevance 0.09 Pain Relevance 0.38
Evidence is presented to support the hypothesis that a transient curtailment in the inhibitory influence of hypothalamic opioid peptides in the morning of proestrus, sets in motion a chain of temporally-related events starting with augmentation of adrenergic tone, leading to accumulation of neuropeptide Y and LHRH in the median eminence and culminating in episodic LHRH and LH hypersecretion in the afternoon of proestrus.
Positive_regulation (accumulation) of neuropeptide Y in median eminence associated with neuropeptide and opioid
17) Confidence 0.45 Published 1985 Journal J. Steroid Biochem. Section Abstract Doc Link 2934578 Disease Relevance 0 Pain Relevance 0.23
Here we focus on neuropeptide tyrosine (NPY), which is upregulated in parallel with galanin.
Positive_regulation (upregulated) of NPY associated with neuropeptide
18) Confidence 0.45 Published 2005 Journal Neuropeptides Section Abstract Doc Link 15893817 Disease Relevance 0.56 Pain Relevance 0.42
The maximal increase in NPY was higher during AR-H040922 (p<0.05) compared with placebo.
Positive_regulation (increase) of NPY
19) Confidence 0.45 Published 2003 Journal Eur. Heart J. Section Body Doc Link 12804926 Disease Relevance 0.07 Pain Relevance 0
NPY tear levels showed no significant changes before and after CPT as compared to baseline values (2.7±0.4 versus 3.3±1.3 ng/ml, respectively, p=NSS; Figure 2).
Positive_regulation (changes) of NPY in tear
20) Confidence 0.43 Published 2011 Journal Molecular Vision Section Body Doc Link PMC3021574 Disease Relevance 0.29 Pain Relevance 0.33

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox