INT15239

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Context Info
Confidence 0.62
First Reported 1991
Last Reported 2010
Negated 4
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 1.14
Pain Relevance 4.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Junb) nucleus (Junb) DNA binding (Junb)
Anatomy Link Frequency
adrenal medulla 2
nerve 1
THP-1 1
pinealocytes 1
PGE2 1
Junb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 10 100.00 Very High Very High Very High
qutenza 15 99.82 Very High Very High Very High
MU agonist 6 99.58 Very High Very High Very High
Morphine 16 98.72 Very High Very High Very High
medulla 9 98.48 Very High Very High Very High
Neurotransmitter 6 98.30 Very High Very High Very High
Hippocampus 3 97.76 Very High Very High Very High
opioid receptor 2 93.76 High High
antagonist 11 92.64 High High
adenocard 2 92.40 High High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 10 98.80 Very High Very High Very High
Colon Cancer 1 96.48 Very High Very High Very High
Acute Monocytic Leukemia 1 94.52 High High
Cancer 5 87.04 High High
Myocardial Infarction 4 86.28 High High
Coronary Artery Disease 4 82.52 Quite High
Bordatella Infection 2 81.20 Quite High
Vibrio Infection 2 75.00 Quite High
Apoptosis 6 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At 10 mg/kg, MDL 72222 had no effect on basal JunB levels, but augmented the response to morphine.
Neg (no) Regulation (effect) of JunB associated with morphine
1) Confidence 0.62 Published 1998 Journal Brain Res. Section Abstract Doc Link 9838105 Disease Relevance 0 Pain Relevance 1.04
Neuronal regulation of c-fos, c-jun, and junB immediate-early genes in rat adrenal medulla.
Regulation (regulation) of junB in adrenal medulla associated with medulla and qutenza
2) Confidence 0.59 Published 1995 Journal J. Neurosci. Section Title Doc Link 7891139 Disease Relevance 0 Pain Relevance 0.44
We have applied in situ hybridization histochemistry, Northern analysis, and immunocytochemistry to study the regulation of the immediate-early gene (IEG) c-fos, c-jun, and junB mRNAs and the respective proteins in the rat adrenal medulla.
Regulation (regulation) of junB in adrenal medulla associated with medulla
3) Confidence 0.59 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7891139 Disease Relevance 0 Pain Relevance 0.26
Neither alpha-, beta-adrenergic nor opioid agonists had any significant effect on jun-B, whereas NOS was slightly increased by isoproterenol.
Regulation (effect) of jun-B associated with mu agonist
4) Confidence 0.54 Published 2001 Journal J. Pineal Res. Section Abstract Doc Link 11555177 Disease Relevance 0 Pain Relevance 0.71
The pre-administration with L-NAME further increased KA-induced c-jun and c-fos mRNA levels in addition to their protein product levels, although the pre-treatment with L-NAME did not affect KA-induced FosB, Fra-2, JunB, and JunD protein levels at 6 h after treatment.
Neg (not) Regulation (affect) of JunB
5) Confidence 0.53 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602069 Disease Relevance 0 Pain Relevance 0.07
Although stimulation of both nicotinic and muscarinic cholinergic receptors may mediate the induction of these IEGs, it is possible that also another neurotransmitter(s), in addition to ACh, released from splanchnic nerve terminals is involved in the regulation of their expression, especially of c-jun and junB.
Regulation (regulation) of junB in nerve associated with neurotransmitter
6) Confidence 0.44 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7891139 Disease Relevance 0 Pain Relevance 0.41
The treatment with CTX, but not PTX, increased c-Fos and Fra-2 protein levels as well as AP-1, CRE, or ENKCRE-2 DNA binding activity, but neither toxin affected Fra-1, c-Jun, JunB, and JunD protein levels.
Neg (neither) Regulation (affected) of JunB
7) Confidence 0.42 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11295234 Disease Relevance 0.30 Pain Relevance 0.04
The effects of adrenergic agonists on c-fos, jun-B and nitric oxide synthase-like immunoreactivities in cultured rat pinealocytes.
Regulation (effects) of jun-B in pinealocytes associated with agonist
8) Confidence 0.40 Published 2001 Journal J. Pineal Res. Section Title Doc Link 11555177 Disease Relevance 0 Pain Relevance 0.37
Thus, biphasic changes in locomotion induced by caffeine are paralleled by biphasic changes in mRNA for NGFI-A, NGFI-B, and jun B.
Regulation (changes) of jun B
9) Confidence 0.39 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7472512 Disease Relevance 0 Pain Relevance 0.37
However, c-Jun, JunB, and JunD protein levels were not affected by PGE2.
Neg (not) Regulation (affected) of JunB in PGE2
10) Confidence 0.36 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9757037 Disease Relevance 0 Pain Relevance 0.04
Resveratrol decreases the levels of miR-155 in THP-1 and modulating JunB and JunD, key regulators in carcinogenesis [31].
Regulation (modulating) of JunB in THP-1
11) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009730 Disease Relevance 0.66 Pain Relevance 0.04
We have used primary cortical cultures to study the regulation of four of these genes, c-fos, c-jun, jun-B, and zif268.
Regulation (regulation) of jun-B
12) Confidence 0.09 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 1719131 Disease Relevance 0 Pain Relevance 0.13
The response was rapid and transient (30 min to 4 hr) for NGFI-A, junB and c-fos mRNA.
Regulation (response) of junB
13) Confidence 0.06 Published 1993 Journal Neuropharmacology Section Abstract Doc Link 8295713 Disease Relevance 0.17 Pain Relevance 0.18

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