INT152404

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Context Info
Confidence 0.45
First Reported 2004
Last Reported 2008
Negated 1
Speculated 1
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.02
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PKD1) nucleus (PKD1) cilium (PKD1)
cytoplasm (PKD1)
PKD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 6 99.12 Very High Very High Very High
Stimulus evoked pain 1 99.12 Very High Very High Very High
qutenza 6 97.68 Very High Very High Very High
headache 3 93.24 High High
burning pain 1 86.80 High High
Disease Link Frequency Relevance Heat
Pain 7 99.12 Very High Very High Very High
Hypersensitivity 1 98.92 Very High Very High Very High
Cerebral Aneurysm 12 94.40 High High
Polycystic Kidney Disease 18 94.36 High High
Headache 3 93.24 High High
Hypertension 6 92.24 High High
Chronic Renal Failure 27 91.08 High High
Disease 48 85.20 High High
Autosomal Dominant Polycystic Kidney 63 82.32 Quite High
Nociception 1 72.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Direct sequencing of the entire PKD1 gene is however very expensive if mutation screening is not initially performed and it may not be appropriate for such a large gene as PKD1.
Neg (not) Spec (may) Regulation (appropriate) of PKD1
1) Confidence 0.45 Published 2004 Journal BMC Med Genet Section Body Doc Link PMC356914 Disease Relevance 0.08 Pain Relevance 0
Obvious mobility shifts in the MRF-SSCP analysis were observed in SI-7 PCR product from PKD1 cDNA of an affected member (II-1) of this family when compared with the normal counterparts (Figure 5A).
Regulation (affected) of PKD1
2) Confidence 0.27 Published 2004 Journal BMC Med Genet Section Body Doc Link PMC356914 Disease Relevance 0.58 Pain Relevance 0
The MRF-SSCP analysis of nested-PCR fragments amplified with SI4F/SI4B primers (SI 4) from PKD1 cDNA of an affected person (I-1) in this family revealed mobility shifts of restriction fragments digested with either Ava II or Bgl I + Hha I (Figure 4A).
Regulation (affected) of PKD1
3) Confidence 0.27 Published 2004 Journal BMC Med Genet Section Body Doc Link PMC356914 Disease Relevance 0.58 Pain Relevance 0.09
Thus, the studies of the functional regulation of TRPV1 are mainly focused on two aspects: to develop more potent analogues of capsaicin with less side effects; or to elucidate the mechanisms of TRPV1 in pain sensitivity, especially of that TRPV1 as a target of various protein kinases such as PKD1 and Cdk5 is involved pain hypersensitivity.
Regulation (target) of PKD1 associated with pain, qutenza, hypersensitivity and stimulus evoked pain
4) Confidence 0.06 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 18528757 Disease Relevance 0.77 Pain Relevance 0.94

General Comments

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