INT15242

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Context Info
Confidence 0.62
First Reported 1991
Last Reported 2009
Negated 2
Speculated 3
Reported most in Title
Documents 14
Total Number 18
Disease Relevance 4.33
Pain Relevance 9.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Homer1) cytoplasm (Homer1)
Anatomy Link Frequency
striatum 4
neurons 4
urinary bladder 2
forebrain 2
hippocampus 2
Homer1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 19 100.00 Very High Very High Very High
antagonist 16 100.00 Very High Very High Very High
Enkephalin 16 100.00 Very High Very High Very High
agonist 9 100.00 Very High Very High Very High
narcan 6 100.00 Very High Very High Very High
qutenza 5 100.00 Very High Very High Very High
isoflurane 5 100.00 Very High Very High Very High
opioid receptor 4 100.00 Very High Very High Very High
substance P 3 100.00 Very High Very High Very High
Raphe 2 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 4 100.00 Very High Very High Very High
INFLAMMATION 7 99.76 Very High Very High Very High
Cv Unclassified Under Development 2 99.12 Very High Very High Very High
Colitis 5 98.24 Very High Very High Very High
Depression 11 97.68 Very High Very High Very High
Nociception 6 96.84 Very High Very High Very High
Shock 30 96.16 Very High Very High Very High
Anxiety Disorder 58 95.80 Very High Very High Very High
Urological Neuroanatomy 12 95.28 Very High Very High Very High
Inflammatory Bowel Disease 1 94.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Low Vesl-1 expression levels were detected in the CA2 area of the hippocampus, the olfactory bulb, the brain stem, and the cerebellum; thus, we successfully generated short-form-specific KO mice in which the expression of Vesl-1L protein was unaltered.


Regulation (unaltered) of Gene_expression (expression) of Vesl-1L in hippocampus associated with hippocampus
1) Confidence 0.62 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.45 Pain Relevance 0.13
D1 dopamine receptor-deficient mouse: cocaine-induced regulation of immediate-early gene and substance P expression in the striatum.
Regulation (regulation) of Gene_expression (expression) of immediate-early gene in striatum associated with dopamine receptor, enkephalin, substance p and cocaine
2) Confidence 0.44 Published 1996 Journal Neuroscience Section Title Doc Link 8884777 Disease Relevance 0 Pain Relevance 0.67
In this study, we successfully generated short form Vesl-1-specific KO mice without affecting the expression of the long form of Vesl-1, which is a splicing isoform of the vesl-1 gene.
Neg (without) Regulation (affecting) of Gene_expression (expression) of vesl-1
3) Confidence 0.27 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.33 Pain Relevance 0
Given that the pontine parabrachial nucleus has been implicated in nociceptive as well as antinociceptive processes and is reciprocally connected with the spinal cord dorsal horn, it seems likely that peripheral inflammation will cause alterations in immediate early gene expression in this nucleus.
Regulation (alterations) of Gene_expression (expression) of immediate early gene in parabrachial nucleus associated with nociception, inflammation, dorsal horn, antinociceptive, spinal cord and parabrachial
4) Confidence 0.26 Published 1996 Journal J. Comp. Neurol. Section Abstract Doc Link 8907357 Disease Relevance 0.70 Pain Relevance 0.65
In situ hybridization showed that after injecting muscimol in the D2R-/- mice, the expression of enkephalin and immediate early gene, NGFI-A, was closely regulated with the locomotor activity regulated by GABAergic stimulation.
Regulation (regulated) of Gene_expression (expression) of immediate early gene associated with gabaergic, eae and enkephalin
5) Confidence 0.17 Published 2004 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 15080900 Disease Relevance 0.16 Pain Relevance 0.69
Cystometrographic recording and immunocytochemical techniques were used to examine the effects of ZD6169, an ATP-sensitive K+-channel opener, and capsaicin, an afferent neurotoxin, on urinary bladder hyperactivity and immediate early gene expression in the spinal cord induced by acetic acid (0.25%) irritation of the bladder.
Spec (examine) Regulation (effects) of Gene_expression (expression) of immediate early gene in urinary bladder associated with qutenza, attention deficit hyperactivity disorder and spinal cord
6) Confidence 0.05 Published 1998 Journal Brain Res. Section Abstract Doc Link 9756985 Disease Relevance 0.48 Pain Relevance 0.22
Chronic administration of morphine alters immediate-early gene expression in the forebrain of post-dependent rats.
Regulation (alters) of Gene_expression (expression) of immediate-early gene in forebrain associated with morphine
7) Confidence 0.05 Published 1999 Journal Brain Res. Section Title Doc Link 10415375 Disease Relevance 0 Pain Relevance 0.81
The effects of pentobarbital, isoflurane, and propofol on immediate-early gene expression in the vital organs of the rat.
Regulation (effects) of Gene_expression (expression) of immediate-early gene associated with isoflurane
8) Confidence 0.03 Published 2000 Journal Anesth. Analg. Section Title Doc Link 10781476 Disease Relevance 0 Pain Relevance 0.20
Although no sensitization of immediate-early gene expression was observed in the present study, a dorsal–ventral gradient was seen in acute response to amphetamine with the prelimbic area showing a 74% increase in the SA group over the SS group and the infralimbic area showing a smaller increase at 45%.
Neg (no) Regulation (sensitization) of Gene_expression (expression) of immediate-early gene in dorsal-ventral
9) Confidence 0.03 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2362139 Disease Relevance 0 Pain Relevance 0.15
Thus, the effects of systemic and intrastriatal administration of various opioid receptor agonists and antagonists on immediate-early gene expression (c-fos, zif 268) induced by the D2 receptor antagonist eticlopride were examined with in situ hybridization histochemistry.
Spec (examined) Regulation (effects) of Gene_expression (expression) of immediate-early gene associated with antagonist, agonist and opioid receptor
10) Confidence 0.02 Published 1999 Journal Neuroscience Section Abstract Doc Link 10363818 Disease Relevance 0 Pain Relevance 1.67
Differential modulatory effects of alpha- and beta-adrenoceptor agonists and antagonists on cortical immediate-early gene expression following focal cerebrocortical lesion-induced spreading depression.
Regulation (effects) of Gene_expression (expression) of immediate-early gene associated with depression, antagonist and agonist
11) Confidence 0.02 Published 2000 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 11072104 Disease Relevance 0.53 Pain Relevance 0.53
Role of the dorsal raphe nucleus in morphine-induced immediate early gene expression in the rat striatum.
Regulation (Role) of Gene_expression (expression) of immediate early gene in striatum associated with raphe and morphine
12) Confidence 0.02 Published 1999 Journal Brain Res. Section Title Doc Link 10526114 Disease Relevance 0.28 Pain Relevance 0.98
Synaptic regulation of immediate early gene expression in primary cultures of cortical neurons.
Regulation (regulation) of Gene_expression (expression) of immediate early gene in neurons
13) Confidence 0.01 Published 1991 Journal J. Neurochem. Section Title Doc Link 1719131 Disease Relevance 0 Pain Relevance 0.14
The effect of dizocilpine and enadoline on immediate early gene expression in the gerbil global ischaemia model.
Regulation (effect) of Gene_expression (expression) of immediate early gene associated with cv unclassified under development
14) Confidence 0.01 Published 1993 Journal Neuropharmacology Section Title Doc Link 8295713 Disease Relevance 0.19 Pain Relevance 0.19
Possible roles of JNK pathway in the regulation of hippocampal proenkephalin and immediate early gene expression induced by kainic acid.
Regulation (regulation) of Gene_expression (expression) of immediate early gene associated with enkephalin
15) Confidence 0.01 Published 2001 Journal Mol. Cells Section Title Doc Link 11355693 Disease Relevance 0 Pain Relevance 0.41
Effect of nepadutant, a neurokinin 2 tachykinin receptor antagonist, on immediate-early gene expression after trinitrobenzenesulfonic acid-induced colitis in the rat.
Regulation (Effect) of Gene_expression (expression) of immediate-early gene associated with colitis, qutenza and antagonist
16) Confidence 0.01 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 12490601 Disease Relevance 0.92 Pain Relevance 0.61
Effects of Kelatorphan and morphine before and after noxious stimulation on immediate-early gene expression in rat spinal cord neurons.
Regulation (Effects) of Gene_expression (expression) of immediate-early gene in spinal cord neurons associated with analgesic, spinal cord and morphine
17) Confidence 0.01 Published 1994 Journal Pain Section Title Doc Link 8159434 Disease Relevance 0 Pain Relevance 1.12
To identify enteric neurons activated during intestinal motor activity, we examined myenteric plexus of guinea pig small intestinal segments for expression of the immediate early gene product, Fos.
Spec (examined) Regulation (plexus) of Gene_expression (expression) of immediate early gene product in neurons
18) Confidence 0.01 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9277431 Disease Relevance 0 Pain Relevance 0.11

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