INT152428

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Context Info
Confidence 0.07
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.50
Pain Relevance 1.18

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signal transduction (Pde6b) extracellular space (Ghrh) extracellular region (Ghrh)
Ghrh (Mus musculus)
Pde6b (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 3 98.32 Very High Very High Very High
Kinase C 15 94.24 High High
tetrodotoxin 6 84.12 Quite High
Action potential 3 80.92 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 6 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The TTX-R current was increased by 8-bromoadenosine-cAMP (cAMP analog), forskolin (adenylyl-cyclase activator), and 3-isobutyl-1-methylxanthine (phosphodiesterase inhibitor), but the additional, GHRH-induced increase in TTX-R Na+ currents was not affected.
GHRH Positive_regulation (increase) of TTX-R
1) Confidence 0.07 Published 2008 Journal Endocrinology Section Abstract Doc Link 18535104 Disease Relevance 0.16 Pain Relevance 0.42
The GHRH-induced increase in TTX-R Na+ current was not affected by the cAMP antagonist Rp-cAMP or protein kinase A inhibitors KT5720 or H89.
GHRH Positive_regulation (increase) of TTX-R associated with antagonist
2) Confidence 0.07 Published 2008 Journal Endocrinology Section Abstract Doc Link 18535104 Disease Relevance 0.17 Pain Relevance 0.38
GHRH (100 nm) increased the TTX-R Na+ current in a reversible manner.
GHRH Positive_regulation (increased) of TTX-R
3) Confidence 0.06 Published 2008 Journal Endocrinology Section Abstract Doc Link 18535104 Disease Relevance 0.17 Pain Relevance 0.37

General Comments

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