INT152429

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.56
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrh, Gh) extracellular region (Ghrh, Gh) cytosol (Gh)
signal transduction (Gh) mitochondrion (Gh) plasma membrane (Gh)
Anatomy Link Frequency
arcuate nucleus 2
Ghrh (Mus musculus)
Gh (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 37 99.92 Very High Very High Very High
Neuropeptide 3 96.64 Very High Very High Very High
Opioid 1 93.36 High High
Kinase C 8 92.20 High High
tetrodotoxin 3 75.00 Quite High
antagonist 38 74.40 Quite High
Calcium channel 10 53.36 Quite High
Action potential 24 49.08 Quite Low
Glutamate 3 42.32 Quite Low
tolerance 21 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 32 91.28 High High
Disease 13 89.40 High High
Targeted Disruption 64 75.00 Quite High
Syndrome 4 54.20 Quite High
Acromegaly 27 53.84 Quite High
Death 1 42.56 Quite Low
Pituitary Cancer 4 39.08 Quite Low
Obesity 52 5.00 Very Low Very Low Very Low
Impaired Glucose Tolerance 23 5.00 Very Low Very Low Very Low
Insulin Resistance 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Na+-free extracellular medium significantly reduced GHRH-stimulated GH secretion.
GHRH Positive_regulation (stimulated) of Localization (ecretion.) of GH
1) Confidence 0.37 Published 2008 Journal Endocrinology Section Abstract Doc Link 18535104 Disease Relevance 0.14 Pain Relevance 0.38
Ghrelin targets the arcuate nucleus, from where growth hormone releasing hormone (GHRH) neurones trigger GH secretion.
growth hormone releasing hormone Positive_regulation (trigger) of Localization (secretion) of GH in arcuate nucleus
2) Confidence 0.24 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2820089 Disease Relevance 0.07 Pain Relevance 0.07
The hypothalamic stimulatory growth hormone-releasing hormone (GHRH) stimulates GH gene transcription, GH-cell proliferation, and GH release.
GHRH Positive_regulation (stimulates) of Localization (release) of GH
3) Confidence 0.20 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0.17 Pain Relevance 0.10
GHRH stimulates GH secretion whereas that somatostatin inhibits it [1].
GHRH Positive_regulation (stimulates) of Localization (secretion) of GH associated with somatostatin
4) Confidence 0.06 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.18 Pain Relevance 0.19

General Comments

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