INT15243

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Context Info
Confidence 0.61
First Reported 1991
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 19
Total Number 21
Disease Relevance 7.60
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr1) intracellular (Egr1) DNA binding (Egr1)
transcription factor binding (Egr1) cytoplasm (Egr1)
Anatomy Link Frequency
amacrine cells 2
lens 2
neural 2
saliva 1
ACC neurons 1
Egr1 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 1 99.92 Very High Very High Very High
Anterior cingulate cortex 53 99.52 Very High Very High Very High
nMDA receptor 15 99.22 Very High Very High Very High
Hippocampus 125 99.20 Very High Very High Very High
Inflammatory response 18 99.16 Very High Very High Very High
Eae 11 96.84 Very High Very High Very High
long-term potentiation 84 96.40 Very High Very High Very High
Inflammation 65 95.28 Very High Very High Very High
Pyramidal cell 21 88.32 High High
Nerve growth factor 53 87.68 High High
Disease Link Frequency Relevance Heat
Injury 30 99.78 Very High Very High Very High
INFLAMMATION 84 99.16 Very High Very High Very High
Anxiety Disorder 117 98.56 Very High Very High Very High
Lung Cancer 125 98.16 Very High Very High Very High
Cognitive Disorder 144 97.68 Very High Very High Very High
Stress 32 97.36 Very High Very High Very High
Shock 92 96.16 Very High Very High Very High
Melanoma 102 95.92 Very High Very High Very High
Salivary Gland Disease 36 95.28 Very High Very High Very High
Hypoxia 12 95.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All blots were probed for regulation of Egr1, Egr2, Egr3 and Actin; antibodies were stripped for the blot with Reblot (Chemicon Intentional) and three replicates per sample were made.
Regulation (regulation) of Egr1
1) Confidence 0.61 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.16 Pain Relevance 0
First, there is evidence that consolidation and reconsolidation of recognition memory engage common mechanisms, including NMDA receptor activation, MAPK/ERK phosphorylation, zif268 transcriptional regulation, and protein synthesis.
Regulation (regulation) of zif268 associated with nmda receptor
2) Confidence 0.60 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2992451 Disease Relevance 0 Pain Relevance 0.12
In other species it was shown that in a subset of cells, Egr-1 was not regulated by the light intensity but instead regulated by the sign of defocus (i.e. the glucagonergic amacrine cells in the chicken retina and the GAD65 cells in the macaque retina).
Neg (not) Regulation (regulated) of Egr-1 in amacrine cells
3) Confidence 0.60 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.14 Pain Relevance 0
In other species it was shown that in a subset of cells, Egr-1 was not regulated by the light intensity but instead regulated by the sign of defocus (i.e. the glucagonergic amacrine cells in the chicken retina and the GAD65 cells in the macaque retina).
Neg (not) Regulation (regulated) of Egr-1 in amacrine cells
4) Confidence 0.60 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.14 Pain Relevance 0
For example, using a gene array (588 genes) designed for analysis of transcription factors, Landenberg et al demonstrated a 2-fold or greater up-regulation of six genes, including early-growth response gene-1 (Egr-1), Nurr77, tristetraprolin, the inhibitor of kB-alpha (IkB-alpha), Klf-4 (GKLF) and LRG-21, all within two hours of pneumonectomy in mice [9].
Regulation (regulation) of early-growth response gene-1
5) Confidence 0.50 Published 2009 Journal Respir Res Section Body Doc Link PMC2770038 Disease Relevance 0.14 Pain Relevance 0
For example, using a gene array (588 genes) designed for analysis of transcription factors, Landenberg et al demonstrated a 2-fold or greater up-regulation of six genes, including early-growth response gene-1 (Egr-1), Nurr77, tristetraprolin, the inhibitor of kB-alpha (IkB-alpha), Klf-4 (GKLF) and LRG-21, all within two hours of pneumonectomy in mice [9].
Regulation (regulation) of Egr-1
6) Confidence 0.50 Published 2009 Journal Respir Res Section Body Doc Link PMC2770038 Disease Relevance 0.14 Pain Relevance 0
Amongst the activity regulated transcription factors, the immediate early growth response-1 gene Egr1 (also named Zif268, Krox24, NGFI-A and TIS8 or the avian homolog Zenk), a member of the Egr family of transcriptional regulators, is one of the best characterised for its role in neural plasticity and memory formation (Davis et al., 2003; Knapska and Kaczmarek, 2004; O'Donovan et al., 1999 for reviews).
Regulation (regulators) of Egr in neural
7) Confidence 0.45 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0 Pain Relevance 0.05
These findings support a model in which a MAPK/ERK-CREB-Zif268 cascade mediating gene regulation contributes critically to the consolidation of long-term object recognition memory.
Regulation (regulation) of Zif268 associated with cognitive disorder
8) Confidence 0.44 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2992451 Disease Relevance 0.39 Pain Relevance 0.13
However, dissociations have also been shown; for example, in a fear conditioning task, it was shown, using oligonucleotide antisense, that regulation of the transcription factor, Zif268/Egr1 in CA1 of the hippocampus was not necessary for consolidating fear memory, but was necessary for reconsolidation of the active memory (Lee et al., 2004).
Regulation (regulation) of Zif268 in hippocampus associated with anxiety disorder and hippocampus
9) Confidence 0.44 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2992451 Disease Relevance 0.27 Pain Relevance 0.09
The reduction of image intensity therefore had a higher impact on Egr-1 expression level than did the changes in image contrast and spatial frequency content that were induced by diffuser wear.
Regulation (impact) of Egr-1
10) Confidence 0.44 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0 Pain Relevance 0
The relative fold changes of TF expression such as Egr1 and Nr1d1 are different between mRNA levels and protein levels, which may reflect translational modification or proteasomal degradation [25].
Regulation (changes) of Egr1
11) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691577 Disease Relevance 0.87 Pain Relevance 0.07
Amongst the activity regulated transcription factors, the immediate early growth response-1 gene Egr1 (also named Zif268, Krox24, NGFI-A and TIS8 or the avian homolog Zenk), a member of the Egr family of transcriptional regulators, is one of the best characterised for its role in neural plasticity and memory formation (Davis et al., 2003; Knapska and Kaczmarek, 2004; O'Donovan et al., 1999 for reviews).
Regulation (regulators) of immediate early growth response-1 in neural
12) Confidence 0.44 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0 Pain Relevance 0.05
On the other hand, down-regulation of EGR1, a master switch of inflammatory responses prompted by oxidative stress [103], counteracts angiogenesis, thus increasing hypoxic conditions, but has an anti-inflammatory effect.
Regulation (regulation) of EGR1 associated with stress, inflammatory response, inflammation and hypoxia
13) Confidence 0.32 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 1.53 Pain Relevance 0.31
Furthermore, we show the involvement of NF-kappaB and Egr-1 transcription factors in the transcriptional induction of these enzymes.
Regulation (involvement) of Egr-1
14) Confidence 0.30 Published 2010 Journal Cell. Signal. Section Abstract Doc Link 20546888 Disease Relevance 0.38 Pain Relevance 0.15
Regulation of Egr member proteins was assessed 2?
Regulation (Regulation) of Egr
15) Confidence 0.27 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.41 Pain Relevance 0.03
After overlapping the associated genes of each TF, it can be seen that the altered activities of the three TFs (RunX1, MLXIPL and TRIM30) can be potentially responsible for 83% of the up-regulated mRNAs in saliva (Fig. 4G) whereas the collective altered activities of Egr1, Tbx1 and Nr1d1 can potentially account for 63% of the down-regulated expression of salivary mRNAs (Fig. 4H).


Regulation (altered) of Egr1 in saliva
16) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691577 Disease Relevance 0.84 Pain Relevance 0.18
In support of plastic changes in the ACC after injury, activity-dependent immediate early genes, such as c-fos, Egr1, adenosine 3',5'-monophosphate response element binding protein (CREB) are activated in the ACC neurons after tissue inflammation or amputation [41,57].
Regulation (dependent) of Egr1 in ACC neurons associated with adenocard, inflammation, injury, amputation and anterior cingulate cortex
17) Confidence 0.15 Published 2007 Journal Mol Pain Section Body Doc Link PMC1904186 Disease Relevance 1.13 Pain Relevance 0.61
To examine in detail the time-course of changes in Zif268, Egr-1, NGFI-A, and Krox-24 (ZENK) and pre-proglucagon (PPG) RNA transcript levels in the chick retina during periods of increased ocular growth induced by form-deprivation and negative-lens wear.
Regulation (changes) of Krox-24 in lens
18) Confidence 0.14 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2855734 Disease Relevance 0.12 Pain Relevance 0.11
To examine in detail the time-course of changes in Zif268, Egr-1, NGFI-A, and Krox-24 (ZENK) and pre-proglucagon (PPG) RNA transcript levels in the chick retina during periods of increased ocular growth induced by form-deprivation and negative-lens wear.
Regulation (changes) of Zif268 in lens
19) Confidence 0.14 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2855734 Disease Relevance 0.11 Pain Relevance 0.11
Moreover, expression of SKIL, a negative regulator of TGF-beta signaling [28], and EGR1, a potent transcription factor with a dual role in tumorigenesis [29], was modulated upon TUSC2 introduction in 4 out of 5 tested MPM cell lines.
Regulation (modulated) of EGR1 associated with lung cancer
20) Confidence 0.11 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2776015 Disease Relevance 0.83 Pain Relevance 0

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