INT152433

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Context Info
Confidence 0.33
First Reported 2004
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 10.97
Pain Relevance 5.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CSF1R) signal transduction (CSF1R) plasma membrane (CSF1R)
Anatomy Link Frequency
skeletal muscle 1
mast cells 1
CSF1R (Homo sapiens)
Pain Link Frequency Relevance Heat
Fibrositis 505 100.00 Very High Very High Very High
Pain 49 100.00 Very High Very High Very High
Serotonin 16 100.00 Very High Very High Very High
chemokine 42 99.82 Very High Very High Very High
Crohn's disease 43 98.72 Very High Very High Very High
cytokine 45 95.20 Very High Very High Very High
Inflammation 55 91.20 High High
Catecholamine 8 89.60 High High
rheumatoid arthritis 25 87.92 High High
psoriasis 1 79.52 Quite High
Disease Link Frequency Relevance Heat
Fibromyalgia 501 100.00 Very High Very High Very High
Pain 54 100.00 Very High Very High Very High
Disease 77 99.60 Very High Very High Very High
Affective Disorder 15 99.52 Very High Very High Very High
Infection 6 99.34 Very High Very High Very High
Anxiety Disorder 9 96.92 Very High Very High Very High
Disease Susceptibility 12 94.00 High High
Syndrome 49 92.40 High High
INFLAMMATION 55 91.20 High High
Rheumatoid Arthritis 25 87.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a case-control study of Louisiana patients with Crohn's disease, we have detected a SNP (A2033T) in the eleventh intron of the CSF1R gene that is significantly associated with the disease.
CSF1R gene Binding (associated) of associated with crohn's disease and disease
1) Confidence 0.33 Published 2004 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC428583 Disease Relevance 0.82 Pain Relevance 0.22
Furthermore, the chemokine profile associated with FMS has direct effects on the migration of eosinophils and monocytes in the presence of mast cells, and skeletal muscle itself may secrete.
FMS Binding (associated) of in skeletal muscle associated with chemokine and fibrositis
2) Confidence 0.29 Published 2008 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 18535166 Disease Relevance 0.82 Pain Relevance 0.64
Gursoy could not find an association between the serotonin transporter (5-HTT) nor its polymorphism with FMS [22].
FMS Neg (nor) Binding (association) of associated with fibrositis and serotonin
3) Confidence 0.27 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779444 Disease Relevance 1.00 Pain Relevance 0.77
Arnold and colleagues [15] tested the hypotheses that FMS and measures of pain and tenderness aggregate in families and that FMS co-aggregates with major mood disorder.
FMS Binding (aggregate) of associated with pain, affective disorder and fibrositis
4) Confidence 0.26 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779444 Disease Relevance 2.17 Pain Relevance 0.98
Given the large number of NLR genes and their growing number of disease associations, it is likely that more NLR gene variants will be found as risk factors for FMS, and that specific chronic infections will be identified that trigger FMS via their interactions with these genes.
FMS Binding (interactions) of associated with disease, fibrositis and infection
5) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794536 Disease Relevance 1.14 Pain Relevance 0.40
In a more comprehensive family study, Arnold et al. [5] assessed familial aggregation of FMS with measures of tenderness and pain, and familial co-aggregation of FMS with major mood disorder.
FMS Binding (aggregation) of associated with pain, affective disorder and fibrositis
6) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794536 Disease Relevance 2.40 Pain Relevance 1.08
Family studies showed a strong familial aggregation of FMS and related conditions [4], [5], [6].
FMS Binding (aggregation) of associated with fibrositis
7) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794536 Disease Relevance 1.79 Pain Relevance 0.80
Furthermore, the chemokine profile associated with FMS has direct effects on the migration of eosinophils and monocytes in the presence of mast cells, and skeletal muscle itself may secrete.
FMS Binding (associated) of in mast cells associated with chemokine and fibrositis
8) Confidence 0.10 Published 2008 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 18535166 Disease Relevance 0.82 Pain Relevance 0.64

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