INT152436

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 10.06
Pain Relevance 2.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (HSPD1) cytosol (HSPD1) mitochondrion (HSPD1)
extracellular space (HSPD1) cell death (HSPD1) ATPase activity (HSPD1)
Anatomy Link Frequency
epithelial cells 4
head 3
endothelial cells 2
neck 1
HSPD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 271 100.00 Very High Very High Very High
Arthritis 37 99.72 Very High Very High Very High
cytokine 130 97.58 Very High Very High Very High
cINOD 7 91.56 High High
Osteoarthritis 6 89.96 High High
rheumatoid arthritis 93 89.52 High High
Infliximab 1 79.40 Quite High
Crohn's disease 50 76.84 Quite High
Pain 4 32.64 Quite Low
metalloproteinase 22 31.88 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 314 100.00 Very High Very High Very High
Shock 44 100.00 Very High Very High Very High
Stress 143 99.96 Very High Very High Very High
Arthritis 29 99.72 Very High Very High Very High
Atherosclerosis 295 99.66 Very High Very High Very High
Inflammatory Bowel Disease 18 98.28 Very High Very High Very High
Osteoarthritis 12 96.92 Very High Very High Very High
Apoptosis 44 93.20 High High
Skin Cancer 4 91.76 High High
Experimental Arthritis 3 91.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of a 60-kDa heat shock protein enhances cytoprotective function of small intestinal epithelial cells.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of 60-kDa heat shock protein in epithelial cells associated with shock
1) Confidence 0.67 Published 2010 Journal Life Sci. Section Title Doc Link 20159025 Disease Relevance 0.27 Pain Relevance 0.18
In this study, we examined the effect of HSP60 or HSP70 overexpression on hydrogen peroxide-induced (H2O2) or indomethacin-induced cell damage in the small intestinal epithelial cells.
Spec (examined) Positive_regulation (overexpression) of Gene_expression (overexpression) of HSP60 in epithelial cells
2) Confidence 0.48 Published 2010 Journal Life Sci. Section Abstract Doc Link 20159025 Disease Relevance 0.26 Pain Relevance 0.18
Considering that mycobacterial heat-shock protein 65 (hsp65) gene transfer can elicit a profound antitumoral effect, this study aimed to establish the safety, maximum-tolerated dose (MTD) and preliminary efficacy of DNA-hsp65 immunotherapy in patients with advanced head and neck squamous cell carcinoma (HNSCC).
Positive_regulation (transfer) of Gene_expression (transfer) of hsp65 in head associated with shock and skin cancer
3) Confidence 0.47 Published 2008 Journal Cancer Gene Ther. Section Abstract Doc Link 18535616 Disease Relevance 0.44 Pain Relevance 0
In addition, inflamed biopsies showed an abundance of HSP60 expression, including in CD4 positive cells, confirming visually a direct link between immunologically relevant cells and expression of HSP in the presence of chronic inflammation.
Positive_regulation (abundance) of Gene_expression (expression) of HSP60 associated with inflammation
4) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765612 Disease Relevance 0.93 Pain Relevance 0.49
The factors leading to synovial HSP60 expression are not known, but heat is obviously not the only factor because normal and osteoarthritic synovial membranes also express this stress protein.
Positive_regulation (leading) of Gene_expression (expression) of HSP60 associated with stress and osteoarthritis
5) Confidence 0.34 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128883 Disease Relevance 1.27 Pain Relevance 0.30
Overexpression of HSP60 might also explain the development of an autoimmune response to this protein because overexpression might go along with altered localization of this normally mitochondria-localized protein [28,29].
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of HSP60
6) Confidence 0.34 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128883 Disease Relevance 1.08 Pain Relevance 0.34
In summary, their autoimmune hypothesis of atherogenesis postulates that HSP60 expression is induced in arterial endothelial cells as a response to the action of stress factors, notably the classical atherosclerotic risk factors.
Positive_regulation (induced) of Gene_expression (expression) of HSP60 in endothelial cells associated with stress and atherosclerosis
7) Confidence 0.22 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1166571 Disease Relevance 1.38 Pain Relevance 0.04
Considering that mycobacterial heat-shock protein 65 (hsp65) gene transfer can elicit a profound antitumoral effect, this study aimed to establish the safety, maximum-tolerated dose (MTD) and preliminary efficacy of DNA-hsp65 immunotherapy in patients with advanced head and neck squamous cell carcinoma (HNSCC).
Positive_regulation (transfer) of in neck Gene_expression (transfer) of hsp65 in head associated with shock and skin cancer
8) Confidence 0.16 Published 2008 Journal Cancer Gene Ther. Section Abstract Doc Link 18535616 Disease Relevance 0.44 Pain Relevance 0
Such a cytokine profile has been speculated to play a role in attenuating the expression of specific CT genes such as MOMP, while promoting the expression of other genes such as hsp60 [43,44].
Positive_regulation (promoting) of Gene_expression (expression) of hsp60 associated with cytokine
9) Confidence 0.12 Published 1999 Journal Arthritis Res Section Body Doc Link PMC128867 Disease Relevance 0.91 Pain Relevance 0.38
induces HSP60 expression enhancing the binding of circulating autoantibodies
Positive_regulation (induces) of Gene_expression (expression) of HSP60
10) Confidence 0.12 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 1.17 Pain Relevance 0
induces HSP60 expression enhancing the binding of circulating autoantibodies
Positive_regulation (enhancing) of Gene_expression (expression) of HSP60
11) Confidence 0.08 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 1.17 Pain Relevance 0
products of the inflammatory process such as endogenous HSP60 and LDL oxidation
Positive_regulation (endogenous) of Gene_expression (products) of HSP60 associated with inflammation
12) Confidence 0.08 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.36 Pain Relevance 0.12
products of the inflammatory process such as endogenous HSP60 and LDL oxidation
Positive_regulation (endogenous) of Gene_expression (products) of HSP60 associated with inflammation
13) Confidence 0.08 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.36 Pain Relevance 0.12

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox