INT152453

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 1.68
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (Gsk3b, Nfkb1) cytoplasm (Gsk3b, Nfkb1) cytosol (Gsk3b, Nfkb1)
nucleolus (Gsk3b, Nfkb1) nucleus (Gsk3b, Nfkb1) mitochondrion (Nfkb1)
Gsk3b (Rattus norvegicus)
Nfkb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 3 100.00 Very High Very High Very High
cINOD 3 91.60 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 6 100.00 Very High Very High Very High
Hematological Disease 9 96.28 Very High Very High Very High
Apoptosis 6 85.84 High High
Leukemia 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, GSK-3beta regulates the pro-inflammatory activity of NF-kappaB.
GSK-3beta Regulation (regulates) of NF-kappaB associated with inflammation
1) Confidence 0.02 Published 2008 Journal Curr. Med. Chem. Section Abstract Doc Link 18537625 Disease Relevance 0.55 Pain Relevance 0.14
In contrast, GSK-3beta positively regulates NF-kappaB, another important biochemical pathway also involved in the regulation of multiple aspects of normal and aberrant haematopoiesis.
GSK-3beta Regulation (regulates) of NF-kappaB associated with hematological disease
2) Confidence 0.01 Published 2008 Journal Curr. Med. Chem. Section Abstract Doc Link 18537625 Disease Relevance 0.57 Pain Relevance 0.09
In this way, GSK-3beta acts to control the resistance of leukaemic cells to chemotherapy through the modulation of NF-kappaB, a critical factor in maintaining leukaemic cell growth.
GSK-3beta Regulation (modulation) of NF-kappaB
3) Confidence 0.01 Published 2008 Journal Curr. Med. Chem. Section Abstract Doc Link 18537625 Disease Relevance 0.57 Pain Relevance 0.13

General Comments

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