INT15246

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Context Info
Confidence 0.60
First Reported 1991
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 32
Total Number 34
Disease Relevance 15.34
Pain Relevance 12.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (FOS) aging (FOS) nucleolus (FOS)
nucleus (FOS)
Anatomy Link Frequency
nucleus 2
spinal cord 1
brainstem 1
diencephalon 1
neuronal 1
FOS (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 65 100.00 Very High Very High Very High
Inflammation 47 100.00 Very High Very High Very High
Neuropeptide 14 100.00 Very High Very High Very High
cytokine 14 100.00 Very High Very High Very High
Dynorphin 13 100.00 Very High Very High Very High
cocaine 53 99.84 Very High Very High Very High
Kinase C 1 99.74 Very High Very High Very High
Spinal cord 24 99.42 Very High Very High Very High
Morphine 16 99.28 Very High Very High Very High
Nucleus accumbens 153 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 93 100.00 Very High Very High Very High
Pain 61 100.00 Very High Very High Very High
INFLAMMATION 59 100.00 Very High Very High Very High
Adhesions 13 100.00 Very High Very High Very High
Osteogenic Sarcomas 4 99.50 Very High Very High Very High
Hypoxia 15 99.14 Very High Very High Very High
Necrosis 3 99.12 Very High Very High Very High
Cancer 55 98.94 Very High Very High Very High
Apoptosis 10 98.72 Very High Very High Very High
Urological Neuroanatomy 25 98.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have used primary cortical cultures to study the regulation of four of these genes, c-fos, c-jun, jun-B, and zif268.
Regulation (regulation) of c-fos
1) Confidence 0.60 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 1719131 Disease Relevance 0 Pain Relevance 0.12
In the present study, we investigated the differential effects of ES or PS on pain behaviors or on c-Fos immunoreactivity (IR) in the paraventricular nucleus (PVN) or arcuate nucleus (ArcN) using electrical footshock-witness model.
Regulation (immunoreactivity) of c-Fos in ArcN associated with stress and pain
2) Confidence 0.60 Published 2008 Journal Brain Res. Section Abstract Doc Link 18086467 Disease Relevance 1.72 Pain Relevance 0.36
The differential effects of emotional or physical stress on pain behaviors or on c-Fos immunoreactivity in paraventricular nucleus or arcuate nucleus.
Regulation (immunoreactivity) of c-Fos in nucleus associated with stress and pain
3) Confidence 0.60 Published 2008 Journal Brain Res. Section Title Doc Link 18086467 Disease Relevance 1.78 Pain Relevance 0.96
Some in vitro studies have reached the conclusion that ERK contributes to c-fos regulation whereas others have provided evidence of ERK-independent c-fos expression.
Regulation (regulation) of c-fos
4) Confidence 0.60 Published 2007 Journal Somatosens Mot Res Section Abstract Doc Link 17558919 Disease Relevance 0.09 Pain Relevance 0.32
On the other hand, c-fos transcriptional control involves histone phosphorylation and acetylation which may vary chromatin condensation state, likely leading to changes in nuclear mass, translated into perimeter variations of immunoreactive nuclei (Clayton et al., 2000; Brami-Cherrier et al., 2009).
Regulation (control) of c-fos
5) Confidence 0.60 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2981384 Disease Relevance 0 Pain Relevance 0.04
The differential effects of emotional or physical stress on pain behaviors or on c-Fos immunoreactivity in paraventricular nucleus or arcuate nucleus.
Regulation (effects) of c-Fos in nucleus associated with stress and pain
6) Confidence 0.44 Published 2008 Journal Brain Res. Section Title Doc Link 18086467 Disease Relevance 1.77 Pain Relevance 0.96
A triple function of PLA2-derived lipid mediators has been suggested: causing immediate inflammatory signs, involvement in secondary processes, e.g., superoxide free radical (O2) generation, apoptosis, or tumour necrosis factor-alpha (TNF-alpha)-cytotoxicity, and controlling the expression and activation of pivotal proteins implicated in inflammation and cell development, e.g., cytokines, adhesion proteins, proteinases, NF-kappaB, fos/jun/AP-1, c-Myc, or p21ras.
Regulation (controlling) of fos associated with necrosis, inflammation, cancer, apoptosis, adhesions and cytokine
7) Confidence 0.44 Published 1997 Journal Expert Opin Investig Drugs Section Abstract Doc Link 15989628 Disease Relevance 0.84 Pain Relevance 0.31
Segregation of c-fos positive nuclei in the color-digitized images was performed in a similar fashion.
Regulation (Segregation) of c-fos
8) Confidence 0.44 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2362139 Disease Relevance 0 Pain Relevance 0.03
To study the activation of the Acb and PFC in detail during the expression of behavioral sensitization, we examined levels of c-fos-like proteins (henceforth c-fos) in detail in the subregions of the Acb and PFC of the rat after an amphetamine challenge in behaviorally sensitized rats.


Spec (examined) Regulation (levels) of c-fos associated with nucleus accumbens
9) Confidence 0.44 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2362139 Disease Relevance 0 Pain Relevance 0.19
We suggest that alterations in c-fos expression patterns in striatofugal circuits following morphine administration may be involved in drug-experience-dependent plasticity.
Regulation (alterations) of c-fos associated with morphine
10) Confidence 0.44 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 15138436 Disease Relevance 0 Pain Relevance 0.64
While there was no difference in nNOS, NGF and c-fos activity between spinal cord regions except the lateral dorsal horn of the L6 section, localization of activities was different in Group-IC.
Neg (no) Regulation (difference) of c-fos in lateral
11) Confidence 0.44 Published 2003 Journal Urol. Int. Section Body Doc Link 12845264 Disease Relevance 0 Pain Relevance 0
In order to determine whether neurotransmitter expression is modulated in response to the elevation of neurotrophins, the changes in c-fos, neuropeptide and glutamic acid decarboxylase (GAD) mRNAs expression was evaluated after BDNF or NT-3 was applied to cultured spinal neurons.
Regulation (changes) of c-fos in neurons associated with neurotransmitter, generalized anxiety disorder and neuropeptide
12) Confidence 0.44 Published 2000 Journal Neuroreport Section Abstract Doc Link 11117506 Disease Relevance 0.33 Pain Relevance 0.29
These mitogen-activated protein kinase pathways regulate a number of transcription factors including c-Fos and c-Jun.
Regulation (regulate) of c-Fos
13) Confidence 0.44 Published 2000 Journal Biochem. Soc. Trans. Section Abstract Doc Link 10816090 Disease Relevance 0.49 Pain Relevance 0.16
In addition, alteration of pain behaviors or c-Fos IR following stress repetition was examined.
Regulation (alteration) of c-Fos associated with stress and pain
14) Confidence 0.44 Published 2008 Journal Brain Res. Section Abstract Doc Link 18086467 Disease Relevance 1.86 Pain Relevance 0.56
The elevation of substance P mRNA in intrinsic spinal cord neurons may be secondary to changes in immediate early genes c-fos and jun-B, whereas the expression of dynorphin and enkephalin mRNA is differently regulated.
Regulation (changes) of c-fos in spinal cord neurons associated with dynorphin, enkephalin, spinal cord and substance p
15) Confidence 0.44 Published 1997 Journal Acta Physiol. Scand. Section Abstract Doc Link 9429659 Disease Relevance 0.31 Pain Relevance 1.54
Three principles of endogenous antinociception have been identified, as follows. (1) Supraspinal descending inhibition: the patterns of neuronal activity in diencephalon, brainstem and spinal cord during antinociceptive stimulation in midbrain periaqueductal gray (PAG) or medullary nucleus raphe magnus have now been mapped on the cellular level, using the c-Fos technique.
Regulation (using) of c-Fos in spinal cord associated with raphe magnus, medulla, antinociception, midbrain, central grey, antinociceptive and spinal cord
16) Confidence 0.44 Published 1996 Journal Prog. Neurobiol. Section Abstract Doc Link 8931107 Disease Relevance 0.58 Pain Relevance 0.86
In the present work, by studying co-localization of c-Fos immunoreactivity and preproenkephalin and preprodynorphin transcripts, we show that co-administration of the A1 receptor agonist CPA and the A2A receptor agonist CGS 21680 increases the striatal expression of c-fos in GABAergic enkephalinergic but not in GABAergic dynorphinergic neurons.
Regulation (immunoreactivity) of c-Fos in CPA associated with gabaergic and agonist
17) Confidence 0.44 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16452987 Disease Relevance 0 Pain Relevance 0.46
After 1 h or 96 h of treatment, Fos and Jun protein levels were altered and the DNA-binding activity of AP-1 was increased in response to both substances.
Regulation (altered) of Fos
18) Confidence 0.43 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15814102 Disease Relevance 0.08 Pain Relevance 0.35
In particular, c-Fos-immunoreactivity was significantly less in the loxoprofen-Na group than in the control group (p < 0.05) (Table 1).


Regulation (immunoreactivity) of c-Fos
19) Confidence 0.26 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2276498 Disease Relevance 0.49 Pain Relevance 0.59
Exposure to amphetamine in a relatively novel environment has been shown to potentiate the c-fos response to the drug in the nucleus accumbens core (Ostrander et al. 2003).The importance of the testing environment was recently underscored by a study showing that sensitized c-fos responses to cocaine in the nucleus accumbens only occurred when cocaine was always administered in a discrete environment outside of the home cage (Hope et al. 2006).
Regulation (responses) of c-fos in nucleus accumbens associated with nucleus accumbens and cocaine
20) Confidence 0.26 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2362139 Disease Relevance 0 Pain Relevance 0.38

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