INT152461

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Context Info
Confidence 0.33
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.57
Pain Relevance 2.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Igh-Dex (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 53 100.00 Very High Very High Very High
Inflammation 23 100.00 Very High Very High Very High
antagonist 1 99.02 Very High Very High Very High
Morphine 8 95.52 Very High Very High Very High
analgesia 4 88.64 High High
Opioid 2 75.00 Quite High
antinociception 3 74.00 Quite High
MU agonist 2 71.84 Quite High
agonist 3 60.48 Quite High
corticosteroid 1 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 24 100.00 Very High Very High Very High
Constipation 2 92.08 High High
Apoptosis 20 61.28 Quite High
Shock 2 39.52 Quite Low
Sprains And Strains 2 25.00 Low Low
Cancer 12 5.00 Very Low Very Low Very Low
Starvation 3 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Reprotox - General 1 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Proteic synthesis inhibitors did not modify the inhibition induced by DEX whereas RU-38486, a glucocorticoid antagonist receptor, antagonized completely the inhibitory effect of DEX.
Negative_regulation (effect) of DEX associated with antagonist and dexamethasone
1) Confidence 0.33 Published 2008 Journal Recent patents on CNS drug discovery Section Abstract Doc Link 18537773 Disease Relevance 0.17 Pain Relevance 1.43
As a control for Dex mediated cellular inflammation suppression, aqueous Dex was added directly to the media of cells inflamed with LPS.
Negative_regulation (suppression) of Dex associated with inflammation and dexamethasone
2) Confidence 0.19 Published 2008 Journal International Journal of Nanomedicine Section Body Doc Link PMC2636579 Disease Relevance 0.40 Pain Relevance 0.79

General Comments

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