INT152501

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.31
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 3.00
Pain Relevance 2.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tnf, Tnfrsf1a) extracellular region (Tnf, Tnfrsf1a) signal transduction (Tnf)
nucleus (Tnfrsf1a) plasma membrane (Tnf) intracellular (Tnf)
Anatomy Link Frequency
Peripheral nerve 2
Tnf (Rattus norvegicus)
Tnfrsf1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 1 99.70 Very High Very High Very High
Neuropathic pain 7 98.96 Very High Very High Very High
Inflammation 4 98.52 Very High Very High Very High
Peripheral nerve injury 2 98.36 Very High Very High Very High
Spinal cord 16 97.80 Very High Very High Very High
c fibre 2 97.34 Very High Very High Very High
Adelta 4 97.18 Very High Very High Very High
nociceptor 6 94.16 High High
dorsal root ganglion 1 93.68 High High
substantia gelatinosa 4 92.60 High High
Disease Link Frequency Relevance Heat
Necrosis 9 100.00 Very High Very High Very High
Cancer 9 100.00 Very High Very High Very High
Neuropathic Pain 8 98.96 Very High Very High Very High
INFLAMMATION 4 98.52 Very High Very High Very High
Nervous System Injury 2 98.36 Very High Very High Very High
Ganglion Cysts 2 92.72 High High
Injury 10 79.04 Quite High
Hyperalgesia 1 68.56 Quite High
Pain 1 5.00 Very Low Very Low Very Low
Hypersensitivity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of TNF-alpha on Adelta/C fiber-evoked monosynaptic and polysynaptic or spontaneous EPSCs were significantly blocked by 5 microM TNF-alpha antagonist that inhibits TNF-alpha binding to its type 1 receptor (TNFR1).
TNF-alpha Binding (binding) of TNFR1 associated with c fibre, antagonist and adelta
1) Confidence 0.31 Published 2008 Journal J. Neurosci. Res. Section Abstract Doc Link 18543334 Disease Relevance 0.49 Pain Relevance 1.04
Co-injection of TNFalpha with P55 or P75 receptor antibodies attenuated TNFalpha-induced mechanical sensitization.
TNFalpha Binding (injection) of P55
2) Confidence 0.24 Published 2009 Journal J. Neurophysiol. Section Abstract Doc Link 19553487 Disease Relevance 0.41 Pain Relevance 0.48
Peripheral nerve injury resulting in neuropathic pain induces the upregulation of interleukin (IL)-6 and tumor necrosis factor-alpha, which binds to tumor necrosis factor receptor 1 (TNFR1) and induces NF-kappaB and p38 MAPK activation in the spinal cord and dorsal root ganglia (DRG).
tumor necrosis factor-alpha Binding (binds) of TNFR1 in Peripheral nerve associated with necrosis, nervous system injury, cancer, neuropathic pain, spinal cord and peripheral nerve injury
3) Confidence 0.23 Published 2009 Journal Eur J Pain Section Abstract Doc Link 18938092 Disease Relevance 1.05 Pain Relevance 0.53
Peripheral nerve injury resulting in neuropathic pain induces the upregulation of interleukin (IL)-6 and tumor necrosis factor-alpha, which binds to tumor necrosis factor receptor 1 (TNFR1) and induces NF-kappaB and p38 MAPK activation in the spinal cord and dorsal root ganglia (DRG).
tumor necrosis factor-alpha Binding (binds) of tumor necrosis factor receptor 1 in Peripheral nerve associated with necrosis, nervous system injury, cancer, neuropathic pain, spinal cord and peripheral nerve injury
4) Confidence 0.23 Published 2009 Journal Eur J Pain Section Abstract Doc Link 18938092 Disease Relevance 1.05 Pain Relevance 0.53

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox