INT152504

Context Info Confidence 0.00 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.49 Pain Relevance 1.04

signal transduction (Tnf) extracellular space (Tnf) extracellular region (Tnf) plasma membrane (Tnf) intracellular (Tnf) extracellular matrix organization (Tnf)

CR1 (Homo sapiens) Tnf (Rattus norvegicus)

Pain Link Frequency Relevance Heat antagonist 1 99.70 c fibre 2 97.34 Adelta 4 97.18 dorsal root ganglion 1 93.12 substantia gelatinosa 4 92.60 Spinal cord 2 75.00 Dorsal horn 1 75.00 allodynia 1 71.44 Thermal hyperalgesia 1 68.56 withdrawal 1 67.20

Disease Link Frequency Relevance Heat Ganglion Cysts 1 92.16 Necrosis 2 75.00 Cancer 2 75.00 Neuropathic Pain 2 71.44 Hyperalgesia 1 68.56 INFLAMMATION 1 52.48 Pain 1 5.00 Hypersensitivity 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The effects of TNF-alpha on Adelta/C fiber-evoked monosynaptic and polysynaptic or spontaneous EPSCs were significantly blocked by 5 microM TNF-alpha antagonist that inhibits TNF-alpha binding to its type 1 receptor (TNFR1).

type 1 receptor Binding (binding) of TNF-alpha associated with c fibre, antagonist and adelta

1) Confidence 0.00 Published 2008 Journal J. Neurosci. Res. Section Abstract Doc Link 18543334 Disease Relevance 0.49 Pain Relevance 1.04

General Comments

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