INT15253

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Context Info
Confidence 0.36
First Reported 1991
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.21
Pain Relevance 3.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (DBH) extracellular region (DBH) cellular nitrogen compound metabolic process (DBH)
cytoplasm (DBH)
Anatomy Link Frequency
neurons 1
nerves 1
DBH (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 199 100.00 Very High Very High Very High
Catecholamine 2 98.48 Very High Very High Very High
Neuropeptide 7 98.16 Very High Very High Very High
Lamotrigine 23 95.92 Very High Very High Very High
depression 47 94.60 High High
Enkephalin 8 91.68 High High
Somatostatin 3 90.92 High High
fluoxetine 5 90.76 High High
Calcitonin gene-related peptide 3 86.36 High High
Serotonin 127 85.08 High High
Disease Link Frequency Relevance Heat
Nicotine Addiction 688 97.20 Very High Very High Very High
Depression 54 94.60 High High
Manic Depressive Disorder 125 84.64 Quite High
Aggression 4 83.28 Quite High
Overactive Bladder 1 83.28 Quite High
Psychosis 4 60.32 Quite High
Disease 11 51.68 Quite High
Stress 5 33.00 Quite Low
Alcohol Addiction 40 5.00 Very Low Very Low Very Low
Neurosis 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, (i) the depletion of catecholamine pools by reserpine also decreases both basal PI metabolism and sEPSC; (ii) hippocampal neurons possess both tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase mRNAs, encoding enzymes required for catecholamine synthesis; and (iii) some hippocampal neurons show TH-immunoreactivity.
dopamine-beta-hydroxylase Binding (possess) of in neurons associated with dopamine and catecholamine
1) Confidence 0.36 Published 2001 Journal Cereb. Cortex Section Abstract Doc Link 11532892 Disease Relevance 0 Pain Relevance 0.49
-hydroxylase (DBH), glucocorticoid receptor (NR3C1), histamine H1 receptor (HRH1) and melanocortin 2 receptor (MCR2) genes were associated with the treatment response.
DBH Binding (associated) of
2) Confidence 0.36 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.44 Pain Relevance 0.45
Another enzyme, dopamine B-hydroxylase (DBH), was also found to be associated with amount smoked per day.
dopamine B-hydroxylase Binding (associated) of associated with dopamine
3) Confidence 0.26 Published 2004 Journal Tob Induc Dis Section Body Doc Link PMC2669467 Disease Relevance 0.68 Pain Relevance 0.32
Another enzyme, dopamine B-hydroxylase (DBH), was also found to be associated with amount smoked per day.
DBH Binding (associated) of associated with dopamine
4) Confidence 0.26 Published 2004 Journal Tob Induc Dis Section Body Doc Link PMC2669467 Disease Relevance 0.67 Pain Relevance 0.32
Another enzyme, dopamine B-hydroxylase (DBH), was also found to be associated with amount smoked per day.
dopamine B-hydroxylase Binding (associated) of associated with dopamine
5) Confidence 0.26 Published 2004 Journal Tob Induc Dis Section Body Doc Link PMC2671538 Disease Relevance 0.68 Pain Relevance 0.32
Another enzyme, dopamine B-hydroxylase (DBH), was also found to be associated with amount smoked per day.
DBH Binding (associated) of associated with dopamine
6) Confidence 0.26 Published 2004 Journal Tob Induc Dis Section Body Doc Link PMC2671538 Disease Relevance 0.67 Pain Relevance 0.32
A similar trend was found for dopamine beta-hydroxylase, 5-hydroxytryptamine and all of the putative neuropeptides in most areas of the prostate, the most notable exceptions being in the peripheral prostate, with an increase in dopamine beta-hydroxylase- and leu-enkephalin-immunoreactive nerves in all three groups of obstructed patients an an increase in vasoactive intestinal polypeptide- and calcitonin gene-related peptide-immunoreactive nerves in those presenting in urinary retention.
dopamine beta-hydroxylase Neg (exceptions) Binding (found) of in nerves associated with dopamine, neuropeptide, overactive bladder, enkephalin and calcitonin gene-related peptide
7) Confidence 0.21 Published 1991 Journal J. Urol. Section Abstract Doc Link 1719253 Disease Relevance 0.08 Pain Relevance 0.93

General Comments

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