INT15255

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Context Info
Confidence 0.46
First Reported 1988
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.87
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PLAT) protein modification process (PLAT) extracellular space (PLAT)
extracellular region (PLAT) cytoplasm (PLAT)
Anatomy Link Frequency
plasma 2
PLAT (Homo sapiens)
Pain Link Frequency Relevance Heat
beta blocker 1 99.52 Very High Very High Very High
antagonist 2 84.40 Quite High
Somatostatin 4 63.76 Quite High
Inflammation 7 50.72 Quite High
anesthesia 2 25.00 Low Low
cva 2 15.60 Low Low
positron emission tomography 8 5.00 Very Low Very Low Very Low
cINOD 8 5.00 Very Low Very Low Very Low
Glutamate 7 5.00 Very Low Very Low Very Low
nMDA receptor 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Amyloid Plaque 7 94.32 High High
Thrombosis 3 77.52 Quite High
Diabetes Mellitus 1 74.28 Quite High
Coronary Heart Disease 1 72.60 Quite High
Drug Induced Neurotoxicity 1 72.08 Quite High
Disease 123 71.80 Quite High
Pathologic Constriction 1 66.40 Quite High
Burns 1 62.36 Quite High
Cognitive Disorder 28 55.04 Quite High
INFLAMMATION 8 50.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with the beta-blocker propranolol completely blocked the increase in t-PA.
Negative_regulation (blocked) of Positive_regulation (increase) of t-PA associated with beta blocker
1) Confidence 0.46 Published 1988 Journal Thromb. Res. Section Abstract Doc Link 2840752 Disease Relevance 0 Pain Relevance 0.05
Pharmacokinetic analysis for functionally active BM 06.022 or alteplase in plasma revealed a total plasma clearance of 4.1-6.6 ml/min/kg for BM 06.022 and of 12.6-42.3 ml/min/kg for alteplase.
Negative_regulation (revealed) of Positive_regulation (active) of alteplase in plasma
2) Confidence 0.42 Published 1991 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 1719279 Disease Relevance 0.39 Pain Relevance 0
Stimulation of plasminogen through tPA (tissue plasminogen activator) and the subsequent generation of plasmin reduces ?
Negative_regulation (reduces) of Positive_regulation (Stimulation) of tPA
3) Confidence 0.06 Published 2009 Journal The Open Neurology Journal Section Body Doc Link PMC2684708 Disease Relevance 0.48 Pain Relevance 0.15

General Comments

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