INT152552

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Context Info
Confidence 0.73
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 43
Disease Relevance 19.44
Pain Relevance 4.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lung 9
epithelium 5
respiratory 2
colon 1
eosinophils 1
Muc5ac (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 20 99.92 Very High Very High Very High
Antinociceptive 16 99.76 Very High Very High Very High
Kappa opioid receptor 6 99.32 Very High Very High Very High
Analgesic 4 99.28 Very High Very High Very High
Morphine 10 98.68 Very High Very High Very High
fibrosis 155 93.00 High High
tail-flick 2 92.68 High High
Inflammation 446 91.72 High High
imagery 20 90.36 High High
tolerance 3 90.08 High High
Disease Link Frequency Relevance Heat
Asthma 141 99.70 Very High Very High Very High
Infection 194 99.48 Very High Very High Very High
Teratoma 75 99.26 Very High Very High Very High
Smoke Inhalation Injury 300 99.04 Very High Very High Very High
Pulmonary Disease 364 98.08 Very High Very High Very High
Hypersensitivity 21 97.12 Very High Very High Very High
Targeted Disruption 33 96.36 Very High Very High Very High
Injury 197 94.60 High High
Occupational Lung Diseases 4 93.76 High High
Disease 139 93.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This elevated expression was abrogated by JNK1 mutation and the JNK inhibitor, indicating the dependence of MUC5AC expression on JNK activity.
Gene_expression (expression) of MUC5AC associated with addiction
1) Confidence 0.73 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.58 Pain Relevance 0.08
For determination of MUC1, MUC4, MUC5AC, and JNK protein expression, Western blot analysis was performed with MUC1 (Abcam, Cambridge, UK), MUC 4 (Invitrogen, Carlsbad, California), MUC 5AC antibody and JNK antibodies (Santa Cruz Biotechnology, Santa Cruz, CA, and Cell Signaling Technology, Beverly, MA).
Gene_expression (expression) of MUC5AC
2) Confidence 0.73 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.07 Pain Relevance 0
The quantity of MUC5AC protein production in the airway was assessed by measuring the percentage of MUC5AC positive cells in the airway epithelium.
Gene_expression (production) of MUC5AC in epithelium
3) Confidence 0.73 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0 Pain Relevance 0
MUC5AC and MUC2 are expressed in the goblet cells of the superficial airway epithelium, whereas MUC5B is expressed in the mucosal cells of the submucosal glands [9].
Gene_expression (expressed) of MUC5AC in glands
4) Confidence 0.73 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.75 Pain Relevance 0.05
Four and twenty-four hours after exposure to smoke from burning cotton, we observed that MUC5AC mRNA levels were elevated in the mouse lungs, and MUC5AC protein was expressed predominantly in the surface cells of the mouse airway.
Gene_expression (expressed) of MUC5AC in lungs
5) Confidence 0.73 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.54 Pain Relevance 0.07
The expression level of Muc4 in lung of healthy mice was higher than the expression levels of both Muc5b and Muc5ac RNAs.
Gene_expression (expression) of Muc5ac in lung
6) Confidence 0.73 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0 Pain Relevance 0
In human, it has been reported that MUC5AC expression, measured using real-time RT-PCR, is much higher than both MUC5B and MUC4 in homogenates of endobronchial biopsies from healthy subjects or subjects with asthma [40].
Gene_expression (expression) of MUC5AC associated with asthma
7) Confidence 0.73 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0.18 Pain Relevance 0
In this present study, we did not observe major modification in the Muc5ac expression with the exception of an upregulation at day 7 for the n-6 PUFAs treated group inoculated with sterile beads (Figure 3).
Gene_expression (expression) of Muc5ac
8) Confidence 0.73 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0.23 Pain Relevance 0
P. aeruginosa lung infection did not appear to impact Muc5ac expression over time, regardless of diet.
Gene_expression (expression) of Muc5ac in lung associated with infection
9) Confidence 0.73 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0.18 Pain Relevance 0
The antinociceptive effects of MGM-9 were mediated by both mu- and kappa-opioid receptors.
Gene_expression (mediated) of MGM-9 associated with kappa opioid receptor and antinociceptive
10) Confidence 0.67 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18550129 Disease Relevance 0 Pain Relevance 1.35
In the present study, MUC5AC protein expression was increased within 4 hour after 15 min smoke inhalation.
Gene_expression (expression) of MUC5AC
11) Confidence 0.64 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.63 Pain Relevance 0.08
Only MUC5AC gene expression, which was also evaluated by immunoblotting (Figure 3) and immunohistochemistry (Figure 4), was found to be increased in the wild-type mice subjected to smoke inhalation.
Gene_expression (expression) of MUC5AC
12) Confidence 0.64 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0 Pain Relevance 0.03
Four and twenty-four hours after exposure to smoke from burning cotton, we observed that MUC5AC mRNA levels were elevated in the mouse lungs, and MUC5AC protein was expressed predominantly in the surface cells of the mouse airway.
Gene_expression (levels) of MUC5AC mRNA in lungs
13) Confidence 0.64 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.54 Pain Relevance 0.07
In our mouse model, we followed Muc5b, Muc5ac and Muc4 while the Muc2 messenger was barely undetectable in lung tissue and did not show any variation prior or after instillation by sterile or PAO1-laden agarose beads (data not shown).
Gene_expression (followed) of Muc5ac in lung
14) Confidence 0.63 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0.19 Pain Relevance 0
The expression level of Muc4 in lung of healthy mice was higher than the expression levels of both Muc5b and Muc5ac RNAs.
Gene_expression (expression) of Muc5ac in lung
15) Confidence 0.63 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0 Pain Relevance 0
MUC5AC is the most prevalent mucin subtype in mucus and is known to be specifically produced by airway goblet cells [2,22].
Gene_expression (produced) of MUC5AC in goblet cells
16) Confidence 0.59 Published 2006 Journal Respir Res Section Body Doc Link PMC1570356 Disease Relevance 0.72 Pain Relevance 0.20
MUC5AC gene expression was found to be increased 4 h after smoke exposure, and it remained elevated throughout the 24-h recovery period.
Gene_expression (expression) of MUC5AC
17) Confidence 0.57 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.43 Pain Relevance 0.03
These findings suggested that smoke inhalation can cause the overall up-regulation of MUC5AC production by JNK activation in the bronchial mucosal cells.
Gene_expression (production) of MUC5AC
18) Confidence 0.57 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.30 Pain Relevance 0
An increase in epithelial MUC5AC protein expression is associated with the overproduction of mucus in smoke inhalation injury, and that its expression is related on JNK1 signaling.



Gene_expression (expression) of MUC5AC associated with smoke inhalation injury
19) Confidence 0.57 Published 2010 Journal Respir Res Section Abstract Doc Link PMC3014901 Disease Relevance 0.53 Pain Relevance 0
In this study, we showed that MUC5AC protein overexpression in response to cotton smoke inhalation is tightly regulated via the JNK signaling pathways.
Gene_expression (overexpression) of MUC5AC
20) Confidence 0.57 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.36 Pain Relevance 0

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